Mary Elisabeth Timm

US Patent:

20060171982, Aug 3, 2006

Filed:

Feb 3, 2005

Appl. No.:

11/050217

Inventors:

Mary Timm - Littleton MA, US

International Classification:

A61F 2/06
A61F 13/00

US Classification:

424422000, 623001110

Abstract:

A method is provided for altering a drug release profile of a coating of a medical device. The method includes determining the drug release profile of the coating of the medical device; determining an increased surface area necessary to alter the drug release profile to an altered drug release profile; and increasing a surface area of the coating of the medical device to obtain the altered drug release profile. A method is provided for improving a drug release profile of a coating of a medical device. The method includes determining an expected drug release profile of the coating of the medical device using first process parameters of a coating method; determining an increased surface area necessary to obtain an improved drug release profile; and altering the first process parameters to second process parameters of the coating method to achieve the increased surface area. A device is provided for altering a drug release profile of a coating of a medical device. The device includes an arrangement adapted to hold the medical device and an arrangement adapted to indent a surface area of the coating.

US Patent:

20090123517, May 14, 2009

Filed:

Apr 25, 2008

Appl. No.:

12/109677

Inventors:

Aiden Flanagan - Galway, IE
Robert Herrmann - Boston MA, US
Ken Merdan - Loretto MN, US
Michael Kuehling - Munich, DE
Barry O'Brien - Galway, IE
Torsten Scheuermann - Munich, DE
Scott Schewe - Eden Prairie MN, US
Anurag Singhai - Ashland MA, US
Young-Ho Song - Natick MA, US
Mary Joe Timm - Littleton MA, US
Jan Weber - Maastricht, NL
Yixin Xu - Newton MA, US

International Classification:

A61F 2/82
A61L 27/00

US Classification:

424423, 427 221

Abstract:

An implantable medical device for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted.