Matthew S Clark

US Patent:

7427939, Sep 23, 2008

Filed:

Dec 28, 2006

Appl. No.:

11/617389

Inventors:

Matthew Clark - Wake Forest NC, US
Wes Smith - Raleigh NC, US

Assignee:

Intel Corporation - Santa Clara CA

International Classification:

H03M 1/12

US Classification:

341155, 341120

Abstract:

An apparatus, system and method for providing electronic dispersion compensation. In one embodiment an apparatus may include an analog-to-digital converter and a plurality of adaptive filters arranged in parallel. The analog-to-digital converter may output blocks of samples, associated portions of which may be provided as inputs to the filters. Data combining circuitry may receive each of the associated outputs and provide a digital signal output. Of course, many alternatives, variations, and modifications are possible without departing from this embodiment.

US Patent:

7935658, May 3, 2011

Filed:

Oct 4, 2007

Appl. No.:

11/906939

Inventors:

Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Bedford MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen, DK
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Lynn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US

Assignee:

Praecis Pharmaceuticals, Inc. - Waltham MA

International Classification:

C40B 30/10

US Classification:

506 12, 506 7, 506 13, 506 23, 435 6, 435 5, 435 912, 536 231, 536 242

Abstract:

The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods generally include providing a solution comprising initiator compounds comprising an initial functional moiety which comprises n building blocks which comprise at least one reactive group, which is operatively linked to an initial oligonucleotide; dividing the solution into reaction vessels; reacting the initiator compounds in each reaction vessel with a building block comprising a complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide in each aliquot with a distinct incoming oligonucleotide in the presence of an enzyme which catalyzes the ligation of the incoming oligonucleotide and the initial oligonucleotide, under conditions suitable for enzymatic ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide which identifies the structure of the functional moiety.

US Patent:

7972992, Jul 5, 2011

Filed:

Dec 17, 2004

Appl. No.:

11/015458

Inventors:

Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - San Francisco CA, US
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US

Assignee:

Praecis Pharmaceuticals, Inc. - Waltham MA

International Classification:

C40B 50/00

US Classification:

506 23, 506 7, 506 13, 435 6

Abstract:

The present invention provides methods of synthesizing a molecule comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods include providing an initiator compound comprising an initial functional moiety comprising n building blocks, wherein the initial functional moiety comprises at least one reactive group, and is operatively linked to an initial oligonucleotide; reacting the initiator compound with a building block comprising at least one complementary reactive group, under conditions suitable for reaction of the complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide with an incoming oligonucleotide corresponding to the building block in the presence of an enzyme which catalyzes ligation of the initial oligonucleotide and the incoming oligonucleotide, under conditions suitable for ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide.

US Patent:

7972994, Jul 5, 2011

Filed:

Jun 9, 2006

Appl. No.:

11/450938

Inventors:

Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paulo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US

Assignee:

GlaxoSmithKline LLC - Philadelphia PA

International Classification:

C40B 50/16

US Classification:

506 31, 506 7, 506 13, 506 23, 506 25, 506 30, 435 6, 435 912, 536 231, 530300, 530350

Abstract:

The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide, wherein the encoding oligonucleotide comprises a capping sequence containing degenerate nucleotides. The methods generally include providing a solution comprising initiator compounds comprising an initial functional moiety comprising n building blocks which is operatively linked to an initial oligonucleotide; dividing the solution into reaction vessels; reacting the initiator compounds in each reaction vessel with a building block comprising a complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide in each aliquot with a distinct incoming oligonucleotide in the presence of an enzyme which catalyzes the ligation of the incoming oligonucleotide and the initial oligonucleotide, under conditions suitable for enzymatic ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide.

US Patent:

7989395, Aug 2, 2011

Filed:

Oct 23, 2006

Appl. No.:

11/584880

Inventors:

Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Bedford MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Lynn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US

Assignee:

GlaxoSmithKline LLC - Philadelphia PA

International Classification:

C40B 50/16

US Classification:

506 31, 506 23, 506 16, 506 5, 435 6, 435 912, 536 231, 536 242

Abstract:

The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.

US Patent:

8410028, Apr 2, 2013

Filed:

Mar 18, 2011

Appl. No.:

13/051314

Inventors:

Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Fairfax VA, US
Steffan Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford WA, US

Assignee:

GlaxoSmithKline LLC - Philadelphia PA

International Classification:

C40B 50/08
C40B 50/06
C40B 50/10

US Classification:

506 27, 506 26, 506 28

Abstract:

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

US Patent:

8598089, Dec 3, 2013

Filed:

Mar 4, 2011

Appl. No.:

13/040674

Inventors:

Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Fairfax VA, US
Steffan Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US

Assignee:

GlaxoSmithKline LLC - Philadelphia PA

International Classification:

C40B 40/06
C12P 19/34

US Classification:

506 16, 536 221, 536 243

Abstract:

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

US Patent:

20110136697, Jun 9, 2011

Filed:

Feb 9, 2011

Appl. No.:

13/023599

Inventors:

Barry MORGAN - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Bedford MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Lynn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US

Assignee:

Praecis Pharmaceuticals Incorporated - Waltham MA

International Classification:

C40B 50/06

US Classification:

506 26

Abstract:

The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.