Matthew Mercer Hall

Address:

1320 N Veitch St UNIT 737, Arlington, VA 22201

VIN:

WBAVA33587KX81423

Make:

BMW

Model:

3 SERIES

Year:

2007

US Patent:

20100316655, Dec 16, 2010

Filed:

Feb 10, 2009

Appl. No.:

12/867206

Inventors:

Matthew D. Hall - Washington DC, US
Michael M. Gottesman - Bethesda MD, US
Jennifer L. Hellawell - Philadelphia PA, US
Joseph A. Ludwig - Houston TX, US
Henry M. Fales - Silver Spring MD, US
Noeris K. Salam - Jersey City NJ, US
Gergely Szakács - Budapest, HU

International Classification:

A61K 39/395
A61K 31/404
A61K 31/44
A61K 31/175
A61K 31/403
A61K 31/351
A61K 31/7068
A61K 31/704
A61K 31/437
A61K 31/7048
A61K 31/337
A61K 31/506
A61K 38/12
A61P 35/00
A61P 35/02

US Classification:

4241741, 514418, 514353, 514583, 514581, 514411, 514459, 514 49, 514 34, 514285, 514 27, 514449, 51425218, 514 199

Abstract:

Disclosed herein are drug compounds that have MDR-inverse activity and thus are effective against multidrug-resistant cells. Exemplary compounds disclosed herein have the structure:Examples of the disclosed compounds have been found to have, inter alia, efficacy in directly treating multidrug resistant cells, rendering multidrug resistant cells susceptible to other chemotherapeutics and in some instances reversing multidrug resistance.

US Patent:

20190241551, Aug 8, 2019

Filed:

Jun 21, 2017

Appl. No.:

16/312206

Inventors:

- Bethesda MD, US
- North Carolina NC, US
Kyle Ryan BRIMACOMBE - Bethesda MD, US
Mindy Irene Emily DAVIS - Rockville MD, US
Yuhong FANG - Rockville MD, US
Matthew HALL - Rockville MD, US
Ajit JADHAV - Chantilly VA, US
Li LIU - Germantown MD, US
Natalia MARTINEZ - Rockville MD, US
Andrew Louis MCIVER - Durham NC, US
Rajan PRAGANI - Gaithersburg MD, US
Jason Matthew ROHDE - Poolesville MD, US
Anton SIMEONOV - Bethesda MD, US
Wei ZHAO - Rockville MD, US
Min SHEN - Boyds MD, US

International Classification:

C07D 417/14
C07D 487/08
A61K 31/4995
A61K 31/496

Abstract:

A compound of Formula II or a pharmaceutically acceptable salt thereof, wherein CyN is a cyclic amine group bound via a nitrogen atom; X is C or N; Rand Rare each independently a halogen, CN, CF, CHF, CHF, a C-C10alkyl group, a C1-Calkoxy group, a di(C-Calkyl)amino; m and n are each independently 1, 2, or 3, and represents either a single bond or a double bond, wherein the racemic mixture of 3-(4-(4-chlorophenyl)thiazol-2-yl)-1-(2-ethyl-5-methoxyphenyl)-6-(2-methylprop-1-en-1-yl)-5-(piperazine-1-carbonyl)pyridin-2(1H)-one atropisomers is excluded.