Matthew D Jeffries

age ~54

from McDonough, GA

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Location:

Greater Philadelphia Area

Industry:

Staffing and Recruiting

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Location:

United States

In Vitro System For Replication Of Rna-Dependent Rna Polymerase (Rdrp) Viruses
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US Patent:

20030175683, Sep 18, 2003
Filed:

Jan 31, 2002
Appl. No.:

10/066130
Inventors:

Robert King - West Chester PA, US
Matthew Jeffries - Indianapolis IN, US
Claudio Pasquinelli - Media PA, US
International Classification:

C12Q001/70
G01N033/53
G01N033/537
G01N033/543
C12N007/00
C12N007/01
C12N005/00
C12N005/02
C12P019/34
US Classification:

435/005000, 435/007100, 435/235100, 435/325000, 435/007940, 435/091100
Abstract:

An in vitro method to conduct genomic replication of the viral genomes of viruses that utilize RNA-dependent RNA polymerase for replication (RDRP viruses), such as HCV. The method employs a construct comprising the 3′ and 5′ untranslated regions (UTRs) of the viral genome which are operably linked on the 5′ and 3′ ends of a reporter sequence, in antisense orientation, such that when viral replication is occurring within the cell which produces RDRP, the reporter protein will be made. The method of the invention provides an efficient means for measuring genomic replication in RDRP viruses, and also for the rapid screening of compounds for their ability to inhibit genomic replication of RDRP viruses, including the virus (HCV).

In Vitro System For Replication Of Rna-Dependent Rna Polymerase (Rdrp) Viruses
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US Patent:

20040126388, Jul 1, 2004
Filed:

Dec 12, 2003
Appl. No.:

10/734801
Inventors:

Robert King - West Chester PA, US
Matthew Jeffries - Wilmington DE, US
Claudio Pasquinelli - Media PA, US
International Classification:

C12Q001/70
A61K039/29
US Classification:

424/189100, 435/005000
Abstract:

An in vitro method to conduct genomic replication of the viral genomes of viruses that utilize RNA-dependent RNA polymerase for replication (RDRP viruses), such as HCV. The method employs a construct comprising the 3′ and 5′ untranslated regions (UTRs) of the viral genome which are operably linked on the 5′ and 3′ ends of a reporter sequence, in antisense orientation, such that when viral replication is occurring within the cell which produces RDRP, the reporter protein will be made. The method of the invention provides an efficient means for measuring genomic replication in RDRP viruses, and also for the rapid screening of compounds for their ability to inhibit genomic replication of RDRP viruses, including the Hepatitis C virus (HCV).