Marc Penn - Shaker Heights OH, US Arman Askari - University Heights OH, US Matthew Kiedrowski - Lorain OH, US
Assignee:
The Cleveland Clinic Foundation
International Classification:
A61K038/17
US Classification:
424/093700, 514/002000
Abstract:
A method of treating infarcted myocardial tissue includes, the concentration of SDF-1 protein in the infarcted tissue. The concentration of stem cells in the peripheral blood of the infarcted tissue is also increased. The number of stem cells in the peripheral blood is increased while the concentration of SDF-1 in the infarcted tissue is increased.
Marc Penn - Shaker Heights OH, US Arman Askari - University Heights OH, US Matthew Kiedrowski - Lorain OH, US
Assignee:
The Cleveland Clinic Foundation
International Classification:
A61K045/00 A61K038/18
US Classification:
424/093700, 514/012000
Abstract:
A method of stimulating stem cell differentiation in ischemia damaged tissue comprises the steps of increasing the concentration of VEGF in the ischemia damaged tissue and increasing the concentration of stem cells in the ischemia damaged tissue while the concentration of VEGF in the ischemia damaged tissue is increased.
Genetically Engineered Cells For Therapeutic Applications
Marc Penn - Beachwood OH, US Matthew Kiedrowski - Cleveland OH, US
International Classification:
A61K048/00 C12N005/08
US Classification:
424093210, 435366000
Abstract:
An isolated mesenchymal stem cell, multipotent adult progenitor cell, or other stem cells is genetically modified to express at least one of CXCR4, SDF-1, or a variant thereof.
Marc Penn - Beachwood OH, US Matthew Kiedrowski - Cleveland OH, US
International Classification:
A61K 48/00 A01N 63/00
US Classification:
424093200, 435325000, 435377000
Abstract:
An isolated mesenchymal stem cell, multipotent adult progenitor cell, or other stem cells is genetically modified to express at least one of CXCR4, SDF-1, or a variant thereof.
Genetically Engineered Cells For Therapeutic Applications
Marc Penn - Beachwood OH, US Matthew Kiedrowski - Cleveland OH, US
International Classification:
A61K 48/00 A61K 45/00
US Classification:
424085100, 514044000
Abstract:
An isolated mesenchymal stem cell, multipotent adult progenitor cell, or other stem cells is genetically modified to express at least one of CXCR4, SDF-1, or a variant thereof.
Compositions And Methods For Treating Cardiovascular Disease
A fusion protein for treating cardiovascular disease includes a transcription factor (TF) and a cell-penetrating peptide (CPP). The fusion protein can be expressed from a cell that is delivered to the tissue being treated.
Compositions And Methods Of Promoting Wound Healing
Marc S. Penn - Beachwood OH, US Matthew Kiedrowski - Cleveland OH, US Rahul Aras - Broadview Heights OH, US Joseph Pastore - Concord OH, US
International Classification:
A61K 38/20 A61K 38/00 A61P 17/02
US Classification:
424 852, 514 11
Abstract:
A method of treating a wound in a subject includes administering directly to the wound or an area proximate the wound an amount of SDF-I effective to promote healing of the wound of the subject.
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