Qian Chen - Andover MA, US Jesse Cheng-Lin Chow - Hooksett NH, US Fabian Gusovsky - Andover MA, US Marc Lamphier - North Andover MA, US Matthew Faust Mackey - Melrose MA, US Kenzo Muramoto - Ibaraki, JP Shawn Schiller - Haverhill MA, US Christine J. Shaffer - Litchfield NH, US Mark Spyvee - Hampstead NH, US
International Classification:
A61K 31/55 A61P 37/06 A61P 19/02
US Classification:
51421202
Abstract:
A method of treating a disorder such as rheumatoid arthritis or multiple sclerosis in a subject is carried out by administering to the subject a composition comprising a modulator compound of Th1 differentiation or Th17 expansion.
- Tokyo, JP Hans Hansen - Somerville MA, US Lynn Hawkins - Concord MA, US Sally Ishizaka - Weston MA, US Matthew Mackey - Melrose MA, US Shawn Schiller - Haverhill MA, US Chikako Ogawa - Basel, CH Heather Davis - Haverhill MA, US Atsushi Endo - Andover MA, US
Embodiments of the disclosure relate to selectively substituted quinolone compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
- Tokyo, JP Hans HANSEN - Somerville MA, US Lynn HAWKINS - Concord MA, US Sally ISHIZAKA - Weston MA, US Matthew MACKEY - Melrose MA, US Shawn SCHILLER - Haverhill MA, US Chikako OGAWA - Basel, CH Heather DAVIS - Haverhill MA, US Atsushi ENDO - Andover MA, US
Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
- Tokyo, JP Hans HANSEN - Somerville MA, US Lynn HAWKINS - Concord MA, US Sally ISHIZAKA - Weston MA, US Matthew MACKEY - Melrose MA, US Shawn SCHILLER - Haverhill MA, US Chikako OGAWA - Basel, CH Heather DAVIS - Haverhill MA, US Atsushi ENDO - Andover MA, US
Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
- Bunkyo-ku, Tokyo, JP Hans HANSEN - Somerville MA, US Sally ISHIZAKA - Weston MA, US Matthew MACKEY - Melrose MA, US Shawn SCHILLER - Haverhill MA, US Chikako OGAWA - Basel, CH Sridhar NARAYAN - Belmont MA, US Peter BERTINATO - Old Lyme CT, US Gregory BERGER - East Lyme CT, US Atsushi ENDO - Andover MA, US Robert T. YU - Arlington MA, US Lynn HAWKINS - Concord MA, US
Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
- TOKYO, JP HANS HANSEN - SOMERVILLE MA, US LYNN HAWKINS - CONCORD MA, US SALLY ISHIZAKA - WESTON MA, US MATTHEW MACKEY - MELROSE MA, US SHAWN SCHILLER - HAVERHILL MA, US CHIKAKO OGAWA - BASEL, CH HEATHER DAVIS - HAVERHILL MA, US
Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
Name / Title
Company / Classification
Phones & Addresses
Matthew Mackey Controller
Vesey, Inc. Computer Maintenance and Repair
35 Myrtle St A, Boston, MA 02114
Matthew Mackey Chief Financial Officer, General Manager