Matthew John Mackey

US Patent:

20130324547, Dec 5, 2013

Filed:

May 31, 2013

Appl. No.:

13/907202

Inventors:

Roch Boivin - North Chelmsford MS, US
Eric Carlson - Merrimack NH, US
Atsushi Endo - Andover MA, US
Hans Hansen - Somerville MA, US
Lynn D. Hawkins - Concord MA, US
Sally Ishizaka - Weston MA, US
Matthew Mackey - Melrose MA, US
Sridhar Narayan - Belmont MA, US
Takashi Satoh - Andover MA, US
Shawn Schiller - Haverhill MA, US

International Classification:

C07D 471/04

US Classification:

51425216, 544281, 5142593

Abstract:

Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis

US Patent:

20100305098, Dec 2, 2010

Filed:

Nov 13, 2008

Appl. No.:

12/739334

Inventors:

Qian Chen - Andover MA, US
Jesse Cheng-Lin Chow - Hooksett NH, US
Fabian Gusovsky - Andover MA, US
Marc Lamphier - North Andover MA, US
Matthew Faust Mackey - Melrose MA, US
Kenzo Muramoto - Ibaraki, JP
Shawn Schiller - Haverhill MA, US
Christine J. Shaffer - Litchfield NH, US
Mark Spyvee - Hampstead NH, US

International Classification:

A61K 31/55
A61P 37/06
A61P 19/02

US Classification:

51421202

Abstract:

A method of treating a disorder such as rheumatoid arthritis or multiple sclerosis in a subject is carried out by administering to the subject a composition comprising a modulator compound of Th1 differentiation or Th17 expansion.

US Patent:

20200347050, Nov 5, 2020

Filed:

Apr 10, 2020

Appl. No.:

16/845594

Inventors:

- Tokyo, JP
Eric CARLSON - Merrimack NH, US
Atsushi ENDO - Andover MA, US
Hans HANSEN - Somerville MA, US
Lynn D. HAWKINS - Concord MA, US
Sally ISHIZAKA - Weston MA, US
Matthew MACKEY - Melrose MA, US
Sridhar NARAYAN - Belmont MA, US
Takashi SATOH - Andover MA, US
Shawn SCHILLER - Haverhill MA, US

Assignee:

Eisai R&D Management Co., Ltd. - Tokyo

International Classification:

C07D 471/04
C07D 487/04
A61K 31/519
A61K 31/55

Abstract:

Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

US Patent:

20190057814, Feb 21, 2019

Filed:

Aug 30, 2018

Appl. No.:

16/118179

Inventors:

- Cleveland OH, US
- Arlington VA, US
James S. Shirk - Alexandria VA, US
Mason Wolak - Alexandria VA, US
Zheng Zou - Cleveland OH, US
Matthew Mackey - Warren PA, US
Joel Carr - Warren PA, US

International Classification:

H01G 4/18
B32B 27/30
B29C 47/00
B32B 27/36
H01G 4/20
B32B 7/02
B32B 15/08
B32B 27/08
B29L 31/34
B29L 9/00
B29L 7/00
B29C 47/06

Abstract:

A multilayer polymer dielectric film includes a stack of coextruded, alternating first dielectric layers and second dielectric layers that receive electrical charge. The first dielectric layers include a first polymer material and the second dielectric layers include a second polymer material different from the first polymer material. The first polymer material has a permittivity greater than the second polymer material. The second polymer material has a breakdown strength greater than the first polymer material. Adjoining first dielectric layers and second dielectric layers define an interface between the layers that delocalizes electrical charge build-up in the layers. The stack has substantially the crystallographic symmetry before and during receiving electrical charge.

US Patent:

20180354939, Dec 13, 2018

Filed:

Aug 22, 2018

Appl. No.:

16/108964

Inventors:

- Tokyo, JP
Hans Hansen - Somerville MA, US
Lynn Hawkins - Concord MA, US
Sally Ishizaka - Weston MA, US
Matthew Mackey - Melrose MA, US
Shawn Schiller - Haverhill MA, US
Chikako Ogawa - Basel, CH
Heather Davis - Haverhill MA, US
Atsushi Endo - Andover MA, US

Assignee:

EISAI R&D MANAGEMENT CO., LTD. - Tokyo

International Classification:

C07D 417/14
C07D 403/14
C07D 413/04
C07D 401/10
C07D 401/14
C07D 471/10
C07D 487/10
C07D 471/04
C07D 215/48
C12Q 1/6897
G01N 33/50
C07D 451/04
C07D 487/04
C07D 493/10
C07D 413/14

Abstract:

Embodiments of the disclosure relate to selectively substituted quinolone compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

US Patent:

20180273532, Sep 27, 2018

Filed:

Dec 14, 2017

Appl. No.:

15/841767

Inventors:

- Tokyo, JP
Eric Carlson - Merrimack NH, US
Atsushi Endo - Andover MA, US
Hans Hansen - Somerville MA, US
Lynn D. Hawkins - Concord MA, US
Sally Ishizaka - Weston MA, US
Matthew Mackey - Melrose MA, US
Sridhar Narayan - Belmont MA, US
Takashi Satoh - Andover MA, US
Shawn Schiller - Haverhill MA, US

Assignee:

EISAI R&D MANAGEMENT CO., LTD. - TOKYO

International Classification:

C07D 471/04
A61K 31/55
C07D 487/04
A61K 31/519

Abstract:

Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

US Patent:

20180030045, Feb 1, 2018

Filed:

Aug 7, 2017

Appl. No.:

15/670904

Inventors:

- Tokyo, JP
Hans HANSEN - Somerville MA, US
Lynn HAWKINS - Concord MA, US
Sally ISHIZAKA - Weston MA, US
Matthew MACKEY - Melrose MA, US
Shawn SCHILLER - Haverhill MA, US
Chikako OGAWA - Basel, CH
Heather DAVIS - Haverhill MA, US
Atsushi ENDO - Andover MA, US

Assignee:

EISAI R&D MANAGEMENT CO., LTD. - Tokyo

International Classification:

C07D 417/14
C07D 413/04
C07D 401/10
C07D 401/14
C07D 471/10
C07D 487/10
C07D 471/04
C07D 215/48
C12Q 1/68
G01N 33/50
C07D 451/04
C07D 487/04
C07D 493/10
C07D 413/14
C07D 403/14

Abstract:

Embodiments of the disclosure relate to selectively substituted quinoline compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

US Patent:

20160339032, Nov 24, 2016

Filed:

Aug 10, 2016

Appl. No.:

15/233520

Inventors:

- Tokyo, JP
Eric Carlson - Merrimack NH, US
Atsushi Endo - Andover MA, US
Hans Hansen - Somerville MA, US
Lynn D. Hawkins - Concord MA, US
Sally Ishizaka - Weston MA, US
Matthew Mackey - Melrose MA, US
Sridhar Narayan - Belmont MA, US
Takashi Satoh - Andover MA, US
Shawn Schiller - Haverhill MA, US

International Classification:

A61K 31/519
A61K 31/55

Abstract:

Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis