Matthew J Marshall

US Patent:

20040236082, Nov 25, 2004

Filed:

May 18, 2004

Appl. No.:

10/474171

Inventors:

Matthew Marshall - Richland WA, US
Patrick Shiel - Moscow, RU
Philip Berger - Apex NC, US
Gregory Bohach - Moscow ID, US
Carolyn Bohach - Moscow ID, US

International Classification:

C07K014/31

US Classification:

530/395000

Abstract:

The invention provides mutant pyrogenic toxins. Preferred mutants retain a disulfide loop structure, although the endogenous sequence of the disulfide loop may be modified for example by insertion, deletion and/or substitution of at least one amino acid residue, or by combining a pyrogenic enterotoxin (or a fragment thereof) with another polypeptide to provide a chimeric molecule. Preferred mutants have a disulfide loop having less than about 8 amino acid residues. The invention also provides a system for producing the mutant pyrogenic toxins and methods of use for the mutants.

US Patent:

20140038224, Feb 6, 2014

Filed:

Oct 9, 2013

Appl. No.:

14/050144

Inventors:

Bingwen Liu - Pullman WA, US
Li Yang - Richland WA, US
Zihua Zhu - Richland WA, US
Matthew J. Marshall - Richland WA, US

Assignee:

Battelle Memorial Institute - Richland WA

International Classification:

G01N 21/75
G01N 27/403

US Classification:

435 29, 422 8201, 436150, 4352887

Abstract:

A microfluidic electrochemical device and process are detailed that provide chemical imaging and electrochemical analysis under vacuum at the surface of the electrode-sample or electrode-liquid interface in-situ. The electrochemical device allows investigation of various surface layers including diffuse layers at selected depths populated with, e.g., adsorbed molecules in which chemical transformation in electrolyte solutions occurs.

US Patent:

20160178555, Jun 23, 2016

Filed:

Feb 29, 2016

Appl. No.:

15/056880

Inventors:

- Richland WA, US
Bingwen Liu - Pullman WA, US
Li Yang - Richland WA, US
Zihua Zhu - Richland WA, US
Matthew J. Marshall - Richland WA, US

International Classification:

G01N 27/27
G01N 27/30
G01N 27/48

Abstract:

A microfluidic electrochemical device and process are detailed that provide chemical imaging and electrochemical analysis under vacuum at the surface of the electrode-sample or electrode-liquid interface in-situ. The electrochemical device allows investigation of various surface layers including diffuse layers at selected depths populated with, e.g., adsorbed molecules in which chemical transformation in electrolyte solutions occurs.