Matthew Todd Richards

US Patent:

6424979, Jul 23, 2002

Filed:

Dec 30, 1998

Appl. No.:

09/223018

Inventors:

Eric Bruce Livingston - Fairfax VA
Lisa Conners Vogt - Bethesda MD
Stephen David Gantz - Arlington VA
David Samuel Zipkin - Arlington VA
Matthew Todd Richards - Vienna VA
Sheila Caroline Rocchio - Arlington VA

Assignee:

American Management Systems, Inc. - Fairfax VA

International Classification:

G06F 1700

US Classification:

707511, 707203, 7075011

Abstract:

A system providing views of a technical architecture of an enterprise that take into account the content type interest, level of detail and time frame of desired information. A user, with a browser interface, selects a portal specifying the type of content to be viewed. A profile of the user indicates the level of detail and time frame of information to be obtained. The interface provides the users selection of desired information within the portal in the form of a page request that is converted into queries of a database that seek content satisfying the type, level of detail and time frame attributes of the request. The content is formed into a web page and provided to the interface by the web server. Content is separated into atomic units allowing the information to be rearranged responsive to each users needs.

US Patent:

8227605, Jul 24, 2012

Filed:

Oct 29, 2007

Appl. No.:

12/447709

Inventors:

Cliff C. Cheng - Cambridge MA, US
Xiaohua Huang - Malden MA, US
Thierry O. Fischmann - Scotch Plains NJ, US
Jose S. Duca - Cranford NJ, US
Matthew Richards - Somerville MA, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D 403/00

US Classification:

544366, 544 60, 544111, 548190, 548193, 548196, 546209, 51425402, 5142278, 5142368, 514365

Abstract:

The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.

US Patent:

8318735, Nov 27, 2012

Filed:

Oct 29, 2007

Appl. No.:

12/447710

Inventors:

Cliff C. Cheng - Cambridge MA, US
Xiaohua Huang - Malden MA, US
Thierry O. Fischmann - Scotch Plains NJ, US
Jose S. Duca - Cranford NJ, US
Matthew Richards - Somerville MA, US
Hongbo Zeng - Westford MA, US
Binyuan Sun - Chestnut Hill MA, US
Panduranga Adulla Reddy - Walpole MA, US
Lianyun Zhao - Burlington MA, US
Shuyi Tang - Quincy MA, US
Tzu T. Wong - Belmont MA, US
Praveen K. Tadikonda - Norwood MA, US
Luis E. Torres - Medford MA, US
M. Arshad Siddiqui - Newton MA, US
Michael P. Dwyer - Scotch Plains NJ, US
Kartik M. Keertikar - East Windsor NJ, US
Timothy J. Guzi - Sudbury MA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/5355
A61K 31/496
C07D 401/14
C07D 403/14
C07D 413/14

US Classification:

5142358, 51425305, 51425306, 5142531, 544121, 544362, 544364

Abstract:

The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.

US Patent:

8394960, Mar 12, 2013

Filed:

Oct 27, 2008

Appl. No.:

12/738532

Inventors:

Matthew Richards - Somerville MA, US
Cliff C. Cheng - Cambridge MA, US
Xiaohua Huang - Malden MA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 401/00
A61K 31/445

US Classification:

546209, 514327

Abstract:

The present invention relates to novel Heterocyclic Ether or Thioether Derivatives, compositions comprising the Heterocyclic Ether or Thioether Derivatives, and methods for using the Heterocyclic Ether or Thioether Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase.

US Patent:

8591943, Nov 26, 2013

Filed:

Apr 8, 2010

Appl. No.:

13/263193

Inventors:

Yongqi Deng - Newton MA, US
Binyuan Sun - Chestnut Hill MA, US
Hongbo Zeng - Westford MA, US
Matthew Richards - Somerville MA, US
Cliff C. Cheng - Cambridge MA, US
Yinyan Zhao - Rockville MD, US
Andrew McRiner - Melrose MA, US
Zhaoyang Meng - Lansdale PA, US
Yang Nan - Lansdale PA, US
Mehul F. Patel - Willow Grove PA, US
Iwona E. Wrona - Sharon MA, US
Panduranga Adulla Reddy - Walpole MA, US
Brian M. Eklov - Kalamazoo MI, US
Shuyi Tang - Belmont MA, US
Duan Liu - Arlington MA, US
Amit K. Mandal - Shrewsbury MA, US
Lianyun Zhao - Blue Bell PA, US
M. Arshad Siddiqui - Newton MA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 9/127
A61K 39/395
A61K 31/554
A61K 31/541
A61K 31/5377
A61K 38/50
A61K 31/553
A61K 33/24
A61K 31/704
A61K 31/551
A61K 31/538
A61K 31/519

US Classification:

424450, 424 946, 4241381, 424623, 424649, 4241331, 51425216, 5142332, 5142555, 51421115, 5142522, 514218, 51421016, 514 34, 5142285, 514249, 5142593, 5142305, 51421018

Abstract:

The present invention provides methods for inhibiting mTOR using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with mTOR using such compounds.

US Patent:

20040030697, Feb 12, 2004

Filed:

Jul 31, 2002

Appl. No.:

10/208020

Inventors:

Thomas Cochran - Vienna VA, US
Matthew Richards - Cambridge MA, US
Kevin Fine - Burke VA, US
Jedidiah Fonner - Silver Spring MD, US

Assignee:

American Management Systems, Inc.

International Classification:

G06F017/30

US Classification:

707/009000

Abstract:

The present invention relates to a feedback system for adding feedback functionality to an online content management system without altering the stored online content. The feedback system includes a feedback submission module for providing the content system with information enabling a browser displaying hypertext received from the content management system to select text for specific commenting, providing a feedback form when a portion of the hypertext is highlighted, and storing the selected text along with feedback received with the feedback form after it is returned by the browser. The system may include a personalized feedback status module, a view feedback module, and a feedback management module. The personalized feedback status module: responds to a user request to view feedback submitted by a user by searching the stored feedback; sends results to the browser. The view feedback module: responds to a command from the browser to view feedback stored in the feedback system by sending a search form to the browser, in which a user can enter or select search criteria; responds to return of the search form by applying user-defined search criteria to filter previous feedback entries stored by the feedback system and return the resulting entries to the user's browser for review. The feedback management module enables an administrator to use a browser to review, comment on, and change the approval status, edit, or logically delete feedback entries stored by the feedback system.

US Patent:

20110041126, Feb 17, 2011

Filed:

Aug 13, 2009

Appl. No.:

12/540650

Inventors:

Roger P. Levy - Somerset NJ, US
Jeffrey M. Jaffe - Brookline MA, US
Matthew T. Richards - Sudbury MA, US
Robert A. Wipfel - Draper UT, US

International Classification:

G06F 9/455

US Classification:

718 1

Abstract:

Methods and apparatus involve continuous management of workloads, including regular monitoring, profiling, tuning and fault analysis by way of instrumentation in the workloads themselves. Broadly, features contemplate collecting current state information from remote or local workloads and correlating it to predefined operational characteristics to see if such defines an acceptable operating state. If so, operation continues. If not, remediation action occurs. In a virtual environment with workloads performing under the scheduling control of a hypervisor, state information may also come from a hypervisor as well as any guest user and kernel spaces of an attendant operating system. Executable instructions in the form of probes gather this information from items of the stack available for control and deliver it to the management system. Other features contemplate supporting/auditing third party cloud computing services, validating service level agreements, and consulting independent software vendors. Security, computing systems and computer program products are other embodiments.

US Patent:

20120328691, Dec 27, 2012

Filed:

Oct 29, 2007

Appl. No.:

12/447712

Inventors:

Cliff C. Cheng - Cambridge MA, US
Xiaohua Huang - Malden MA, US
Thierry O. Fischmann - Scotch Plains NJ, US
Jose S. Duca - Cranford NJ, US
Matthew Richards - Somerville MA, US
Hongbo Zeng - Westford MA, US
Binyuan Sun - Chestnut Hill MA, US
Panduranga Adulla Reddy - Walpole MA, US
Tzu T. Wong - Belmont MA, US
Praveen K. Tadikonda - Norwood MA, US
M. Arshad Siddiqui - Newton MA, US
Marc A. Labroli - Moorestown NJ, US
Cory Poker - Bridgewater NJ, US
Timothy J. Guzi - Sudbury MA, US

International Classification:

A61K 31/496
A61K 31/55
C07D 417/12
A61K 31/454
A61K 31/427
A61K 31/541
A61K 31/506
A61K 31/497
C07D 471/10
A61K 31/438
A61K 31/4545
A61K 31/5377
C07D 498/10
A61K 31/5386
A61K 31/551
A61K 33/24
A61K 9/127
A61K 39/395
A61K 31/704
A61K 38/19
A61K 31/7068
A61K 38/50
A61K 38/20
A61K 38/21
A61P 35/00
A61P 35/02
A61N 5/10
C07D 417/14

US Classification:

424450, 544369, 51425402, 544364, 5142531, 540603, 5142171, 546209, 514326, 548200, 514365, 544 587, 5142278, 544295, 51425219, 544357, 51425211, 546 20, 514278, 51425404, 5142102, 546194, 514318, 546193, 544130, 5142368, 51425403, 546 16, 544 71, 544328, 514256, 540575, 514218, 540480, 424649, 4241331, 4241301, 514 34, 424 851, 514 49, 424 946, 424 852, 424 854, 600 1

Abstract:

The present invention relates to novel Anilinopiperazine Derivatives of Formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, cancer, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.