Matthew D Ronsheim from 73 Carriage Way, North Sudbury, MA 01776, age 52

Substituted Imidazo(1,2-A)Pyrimidines And Imidazo(1,2-A) Pyridines As Cannabinoid Receptor Ligands
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US Patent:

7563797, Jul 21, 2009
Filed:

Aug 27, 2007
Appl. No.:

11/845117
Inventors:

Gian-Luca Araldi - East Setauket NY, US
Matthew Ronsheim - Port Jefferson NY, US
Nhut K. Diep - Hauppauge NY, US
Assignee:

Forest Laboratories Holding Limited
International Classification:

C07D 487/04
A61K 31/519
A61P 19/10
A61P 19/02
A61P 25/02
A61P 37/02
US Classification:

5142591, 5142595, 514300, 544281, 546121
Abstract:

The present invention relates to compounds of formula I, II, III or IV:.

Phthalazine Derivatives As Inhibitors Of Protein Kinase
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US Patent:

8349836, Jan 8, 2013
Filed:

Jun 1, 2011
Appl. No.:

13/150819
Inventors:

Gian-Luca Araldi - East Satauket NY, US
Matthew Ronsheim - Port Jefferson NY, US
Melanie Ronsheim - Port Jefferson NY, US
International Classification:

C07D 237/34
A61K 31/502
A61P 31/10
A61P 3/04
A61P 35/00
US Classification:

514248, 544237
Abstract:

The present invention relates to novel phthalazine derivatives and, more particularly, to phthalazine derivatives that are useful as protein kinase inhibitors. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Phthalazine Derivatives As Inhibitors Of Protein Kinase
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US Patent:

8044041, Oct 25, 2011
Filed:

Nov 14, 2007
Appl. No.:

11/939564
Inventors:

Gian-Luca Araldi - East Setauket NY, US
Matthew Ronsheim - Port Jefferson NY, US
Melanie Ronsheim - Port Jefferson NY, US
Assignee:

Forest Laboratories Holdings Limited
International Classification:

C07D 237/30
C07D 237/32
C07D 237/34
C07D 413/12
C07D 243/08
C07D 498/04
A61K 31/502
A61K 31/5355
A61K 31/551
A61K 31/5365
US Classification:

514218, 514248, 5142345, 5142305, 540492, 544237, 544116, 544105
Abstract:

The present invention relates to novel phthalazine derivatives and, more particularly, to phthalazine derivatives of formula (III) that are useful as protein kinase inhibitors. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Reducing Carbohydrate Derivatives Of Adamantane Amines, And Synthesis And Methods Of Use Thereof
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US Patent:

20060211650, Sep 21, 2006
Filed:

Dec 14, 2005
Appl. No.:

11/304977
Inventors:

Sebastian Assenza - Fort Salonga NY, US
Nanzhu Shen - Medford NY, US
Salvatore Iacono - Kings Park NY, US
Yuriy Kalyan - Staten Island NY, US
Peter Viski - Arlington VA, US
Matthew Ronsheim - Port Jefferson NY, US
Assignee:

Forest Laboratories, Inc. - New York NY
International Classification:

A61K 31/7012
C07H 5/06
US Classification:

514053000, 536018700
Abstract:

The present invention relates to reducing carbohydrate derivatives of adamantane amines of Formula A or pharmaceutically acceptable salts, solvates or derivatives thereof, wherein R, R, R, and Rare together or separately H, F, methyl or lower alkyl, alkenyl, or alkynyl groups, and Z is derived from a mono-, di-, oligo-, or poly-saccharide that originally had an aldehyde carbonyl group. The present invention also relates to processes for the preparation of such adamantane amine derivatives, and uses of such derivatives. The compounds of the present invention are useful in the treatment of infections caused by Gram positive or Gram negative bacteria.

Azaindazole Compounds And Methods Of Use
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US Patent:

20070010523, Jan 11, 2007
Filed:

Jun 22, 2006
Appl. No.:

11/474130
Inventors:

Penglie Zhang - Foster City CA, US
Andrew Pennell - San Francisco CA, US
John J. Wright - Redwood City CA, US
Wei Chen - Fremont CA, US
Manmohan Leleti - Sunnyvale CA, US
Matthew Ronsheim - Port Jefferson NY, US
Assignee:

ChemoCentryx, Inc. - Mountain View CA
International Classification:

A61K 31/519
C07D 487/02
US Classification:

514252160, 544262000
Abstract:

Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Pyridoimidazole Derivatives
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US Patent:

20080009491, Jan 10, 2008
Filed:

Jul 2, 2007
Appl. No.:

11/772270
Inventors:

Matthew Ronsheim - Port Jefferson NY, US
Gian-Luca Araldi - East Setauket NY, US
Assignee:

FOREST LABORATORIES HOLDINGS LIMITED - Hamilton
International Classification:

A61K 31/435
A61K 31/535
A61P 25/04
C07D 413/00
C07D 471/02
US Classification:

514233200, 514300000, 544127000, 546121000
Abstract:

The present invention relates to pyridoimidazole derivatives that act as cannabinoid receptor ligands, e.g., CB2 ligands. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

Indazole Derivatives Useful As Melanin Concentrating Receptor Ligands
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US Patent:

20080153810, Jun 26, 2008
Filed:

Nov 14, 2007
Appl. No.:

11/939565
Inventors:

Matthew Ronsheim - Port Jefferson NY, US
Gian-Luca Araldi - East Setauket NY, US
Assignee:

Forest Laboratories Holdings Limited - Hamilton
International Classification:

A61K 31/55
C07D 403/04
A61K 31/497
A61P 25/22
A61P 3/04
A61K 31/454
C07D 403/12
US Classification:

51421709, 540603, 544371, 546211, 51425406, 514322
Abstract:

The present invention relates to novel compounds, in particular, novel indazole that may be used as melanin concentrating hormone receptor ligands, methods of preparing such compounds, compositions containing such compounds, and methods of using such compounds to treat MCH related disorders.

Reducing Carbohydrate Derivatives Of Adamantane Amines, And Synthesis And Methods Of Use Thereof
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US Patent:

20080300390, Dec 4, 2008
Filed:

Jun 24, 2008
Appl. No.:

12/144781
Inventors:

Sebastian P. Assenza - Fort Salonga NY, US
Nanzhu Shen - Medford NY, US
Salvatore Iacono - Kings Park NY, US
Yuriy B. Kalyan - Staten Island NY, US
Peter Viski - Arlington VA, US
Matthew Ronsheim - Port Jefferson NY, US
Assignee:

FOREST LABORATORIES HOLDINGS LIMITED - Hamilton
International Classification:

C07H 15/24
C07H 5/06
C07C 211/61
US Classification:

536 179, 536 291, 564459
Abstract:

The present invention relates to reducing carbohydrate derivatives of adamantane amines of Formula A or pharmaceutically acceptable salts, solvates or derivatives thereof, wherein R, R, R, and Rare together or separately H, F, methyl or lower alkyl, alkenyl, or alkynyl groups, and Z is derived from a mono-, di-, oligo-, or poly-saccharide that originally had an aldehyde carbonyl group. The present invention also relates to processes for the preparation of such adamantane amine derivatives, and uses of such derivatives. The compounds of the present invention are useful in the treatment of infections caused by Gram positive or Gram negative bacteria.

Matthew D Ronsheim