Matthew David Snyder

US Patent:

20220403467, Dec 22, 2022

Filed:

Feb 28, 2022

Appl. No.:

17/682759

Inventors:

- Redwood City CA, US
Matthew William SNYDER - Seattle WA, US

International Classification:

C12Q 1/6881

Abstract:

Provided herein are compounds, methods, and compositions for use in determining the cellular origin of circulating cell-free DNA.

US Patent:

20210010081, Jan 14, 2021

Filed:

May 21, 2020

Appl. No.:

16/880884

Inventors:

- Seattle WA, US
Matthew SNYDER - Seattle WA, US
Martin KIRCHER - Seattle WA, US

International Classification:

C12Q 1/6881
G16H 50/20
G16B 20/00
G16B 40/00
G16B 45/00
C12Q 1/6883

Abstract:

The present disclosure provides methods of determining one or more tissues and/or cell-types contributing to cell-free DNA (“cfDNA”) in a biological sample of a subject. In some embodiments, the present disclosure provides a method of identifying a disease or disorder in a subject as a function of one or more determined more tissues and/or cell-types contributing to cfDNA in a biological sample from the subject.

US Patent:

20200048711, Feb 13, 2020

Filed:

Oct 11, 2017

Appl. No.:

16/340371

Inventors:

- Seattle WA, US
Matthew William SNYDER - Seattle WA, US

International Classification:

C12Q 1/6881

Abstract:

Provided herein are compounds, methods, and compositions for use in determining the cellular origin of circulating cell-free DNA.

US Patent:

20190127794, May 2, 2019

Filed:

Oct 15, 2018

Appl. No.:

16/160990

Inventors:

- Seattle WA, US
Matthew SNYDER - Seattle WA, US
Martin KIRCHER - Seattle WA, US

International Classification:

C12Q 1/6881
C12Q 1/6883
G16H 50/20

Abstract:

The present disclosure provides methods of determining one or more tissues and/or cell-types contributing to cell-free DNA (“cfDNA”) in a biological sample of a subject. In some embodiments, the present disclosure provides a method of identifying a disease or disorder in a subject as a function of one or more determined more tissues and/or cell-types contributing to cfDNA in a biological sample from the subject.

US Patent:

20170211143, Jul 27, 2017

Filed:

Jul 27, 2015

Appl. No.:

15/329228

Inventors:

- Seattle WA, US
Matthew SNYDER - Seattle WA, US
Martin KIRCHER - Seattle WA, US

International Classification:

C12Q 1/68
G06F 19/00
G06F 19/24
G06F 19/26
G06F 19/18

Abstract:

The present disclosure provides methods of determining one or more tissues and/or cell-types contributing to cell-free DNA (“cfDNA”) in a biological sample of a subject. In some embodiments, the present disclosure provides a method of identifying a disease or disorder in a subject as a function of one or more determined more tissues and/or cell-types contributing to cfDNA in a biological sample from the subject.

US Patent:

20150105267, Apr 16, 2015

Filed:

May 24, 2013

Appl. No.:

14/403558

Inventors:

- Seattle WA, US
Jacob Otto Kitzman - Seattle WA, US
Matthew Snyder - Seattle WA, US

International Classification:

C12Q 1/68

US Classification:

506 2

Abstract:

Methods of genome sequencing of a fetus are provided herein. In some embodiments, such methods include steps of predicting inheritance or transmission of an allele from one or more maternal-only heterozygous sites from a maternal genomic sequence to a fetal genome sequence; and predicting inheritance or transmission of an allele from one or more paternal-only heterozygous sites from a paternal genomic sequence to a fetal genome sequence. In some embodiments, the methods may also include predicting transmission of one or more genomic variants at one or more heterozygous sites that are present on both a maternal genomic sequence and a paternal genomic sequence. According to these embodiments, the paternal genomic sequence and the maternal genomic sequence are derived from a biological sample containing DNA. According to other embodiments, the sequencing methods may include a step of predicting de novo mutations in a fetal genomic sequence.