Matthew L Webber

US Patent:

20130101628, Apr 25, 2013

Filed:

Apr 29, 2012

Appl. No.:

13/459234

Inventors:

Matthew J. Webber - Cambridge MA, US
Jörn Tongers - Hannover, DE
Douglas W. Losordo - Chicago IL, US
Samuel I. Stupp - Chicago IL, US

Assignee:

NORTHWESTERN UNIVERSITY - Evanston IL

International Classification:

C07K 14/00

US Classification:

424400, 530300, 530326, 514 133

Abstract:

Disclosed herein is a completely synthetic cell-free therapy based on peptide amphiphile nanostructures designed to mimic the activity of vascular endothelial growth factor (VEGF), one of the most potent angiogenic signaling proteins. The VEGF-mimetic filaments disclosed herein were found to induce phosphorylation of VEGF receptors and induce pro-angiogenic behavior in endothelial cells, indicated by an enhancement in proliferation, survival and migration in vitro.

US Patent:

20160280827, Sep 29, 2016

Filed:

Mar 23, 2016

Appl. No.:

15/078685

Inventors:

- Cambridge MA, US
Eric Andrew Appel - Cambridge MA, US
Yizhou Dong - Dublin OH, US
Robert S. Langer - Newton MA, US
Benjamin C. Tang - Cambridge MA, US
Omid Veiseh - Cambridge MA, US
Weiheng Wang - Bedford MA, US
Matthew J. Webber - Cambridge MA, US
Kun Xue - Cambridge MA, US

International Classification:

C08F 230/06
C08F 220/54
C08F 220/60
A61K 47/32

Abstract:

Described herein are polymers, polymeric gels, or a composition thereof, for drug delivery. The polymers, which include boronic-acid containing moieties (e.g.,and polyol-containing moieties (e.g.,are prepared by free-radical polymerization and can self-assemble into polymeric gels such as hydrogels. Also provided are methods or preparing the polymers, kits involving the polymers and/or polymeric gels or a composition thereof, for use as materials or delivery applications of an agent to a subject.

US Patent:

20150320837, Nov 12, 2015

Filed:

Dec 12, 2013

Appl. No.:

14/652011

Inventors:

- Cambridge MA, US
Hung-Chieh Chou - Cambridge MA, US
Matthew J. Webber - Cambridge MA, US
Benjamin C. Tang - Cambridge MA, US
Yair Levi - Halfa, IL
Yunlong Zhang - Cambridge MA, US
Rosemary Lynn Kanasty - Cambridge MA, US
Arturo Jose Vegas - Cambridge MA, US
Robert A. Langer - Newton MA, US

International Classification:

A61K 38/28
G01N 33/66
G01N 33/74
A61K 47/48

Abstract:

Compounds, compositions, and methods for “smart” delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.