Dr. Swanson graduated from the Southern Illinois University School of Medicine in 1988. He works in Monroe, OH and specializes in Family Medicine. Dr. Swanson is affiliated with Atrium Medical Center and West Chester Hospital.
Us Patents
Methods And Compositions For Treatment Of Diseases Associated With Aberrant Microsatellite Expansion
Maurice S. Swanson - Gainesville FL, US Rahul N. Kanadia - Gainesville FL, US Charles A. Thornton - Rochester NY, US
Assignee:
UNIVERSITY OF FLORIDA RESEARCH AND GRADUATE PROGRAMS - GAINESVILLE FL
International Classification:
A61K 35/76 A61P 21/00 A01K 67/027 C12N 5/06
US Classification:
424 92, 424 932, 800 9, 435354
Abstract:
The present invention provides methods and compositions for the treatment of diseases associated with aberrant microsatellite expansions. Methods of the present invention comprise the use of recombinant adeno-associated virus vectors containing a transgene encoding at least one muscleblind protein. The present invention also provides an animal model for a disease associated with aberrant microsatellite expansion.
Compositions And Methods Related To Protein Displacement Therapy For Myotonic Distrophy
Charles A. Thornton - Rochester NY, US Thurman Wheeler - Rochester NY, US Krzysztof Sobezak - Rochester NY, US Robert Osborne - Rochester NY, US Jill Miller - Rockport NY, US Maurice Swanson - Gainesville FL, US
Assignee:
University of Rochester - Rochester NY University of Florida Research Foundation, Inc. - Gainesville FL
Disclosed are compositions and methods related to the interaction of polyCUG and polyCCUG repeat RNA and proteins that bind to these repetitive RNA sequences. Also disclosed are methods of treating DM1 or DM2 comprising inhibiting the interaction of poly(CUG)or poly(CCUG)RNA with muscleblind proteins, or by causing improvement of spliceopathy in myotonic dystrophy.
Treatment Of Conditions Associated With Myotonic Dystrophy
- Atlanta GA, US - Gainesville FL, US - San Bruno CA, US Maurice Scott SWANSON - Gainesville FL, US Eric Tzy-Shi WANG - Gainesville FL, US Lyndon LIEN - Hillsborough CA, US
International Classification:
A61K 31/5517 A61P 21/00
Abstract:
Disclosed are methods of treating a disorder or disease associated with myotonic dystrophy. Methods of treating a CNS dysfunction and/or cognitive impairment associated with myotonic dystrophy in a subject comprising administering a therapeutically effective amount of a GABAA receptor antagonist or inverse agonist to the subject are disclosed. Methods of treating a myotonic dystrophy associated disease or disorder caused by mis-splicing of GABRG2 in a subject comprising administering a therapeutically effective amount of a GABAA receptor antagonist or inverse agonist to the subject are disclosed. Methods of improving cognitive function or alertness in a subject having myotonic dystrophy comprising administering a therapeutically effective amount of a GABAA receptor antagonist or inverse agonist to the subject are disclosed. Examples of the GABAA receptor antagonist or inverse agonist include flumazenil, clarithromycin, a fluoroquinolone, picrotoxin, bicuculline, gabazine, cicutoxin, oenan-thotoxin, pentylenetetrazol, Ro15-4513, sarmazenil, amentoflavone, zinc, and any combination thereof.