Maxine Johanna Allen

US Patent:

6383792, May 7, 2002

Filed:

Dec 3, 1999

Appl. No.:

09/454818

Inventors:

Maxine J. Allen - Encinitas CA
Marc Rutter - San Diego CA
Alan J. Buckler - Cardiff CA

Assignee:

AxyS Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C12N 914

US Classification:

435195, 530350

Abstract:

The invention features polynucleotides encoding novel GTP-binding polypeptides, hereinafter referred to as RAQ polypeptides; expression vectors comprising a RAQ polynucleotide of the invention; isolated cells comprising a RAQ-encoding vector; a transgenic non-human animal comprising an alteration in a RAQ gene; and the use of RAQ polynucleotides in detecting in an individual the presence of a genetic polymorphism of a RAQ gene. The invention further features novel RAQ polypeptides; monoclonal antibodies specific for RAQ polypeptides; and a method for making RAQ polypeptides.

US Patent:

61000582, Aug 8, 2000

Filed:

Aug 12, 1997

Appl. No.:

8/909954

Inventors:

Maxine J. Allen - San Diego CA
Alan J. Buckler - Encinitas CA

Assignee:

AxyS Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C12P 2106
C07H 2102
C07H 2104
C12N 900

US Classification:

435 691

Abstract:

Methods for isolating GAP12 genes are provided. The GAP12 nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.

US Patent:

60177101, Jan 25, 2000

Filed:

May 13, 1998

Appl. No.:

9/078317

Inventors:

Maxine J. Allen - Encinitas CA
Marc Rutter - San Diego CA
Alan J. Buckler - Cardiff CA

Assignee:

AxyS Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C12Q 168
C12Q 2106
C12N 1500
C12N 500
C07H 2102

US Classification:

435 6

Abstract:

The invention features polynucleotides encoding novel GTP-binding polypeptides, hereinafter referred to as RAQ polypeptides; expression vectors comprising a RAQ polynucleotide of the invention; isolated cells comprising a RAQ-encoding vector; a transgenic non-human animal comprising an alteration in a RAQ gene; and the use of RAQ polynucleotides in detecting in an individual the presence of a genetic polymorphism of a RAQ gene. The invention further features novel RAQ polypeptides; monoclonal antibodies specific for RAQ polypeptides; and a method for making RAQ polypeptides.