Maxwell Martin Anderson

US Patent:

7569542, Aug 4, 2009

Filed:

Nov 12, 2003

Appl. No.:

10/706391

Inventors:

Randal Eckert - Los Angeles CA, US
Fengxia Qi - Harbor City CA, US
Wenyuan Shi - Los Angeles CA, US
Maxwell H. Anderson - Seattle WA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 38/16
A61K 38/00
C07K 4/04

US Classification:

514 12, 514 13, 514 14, 530300, 530324, 530326, 530327

Abstract:

The present invention is based on the discovery of a composition that provides targeted anti-microbial effect. Specifically the composition contains a targeting moiety which recognizes a target microbial organism and an anti-microbial peptide moiety which has anti-microbial activity. In addition, the present invention provides methods of treating a microbial infection, e. g. , on mucosal surfaces by using the compositions provided by the present invention.

US Patent:

7875598, Jan 25, 2011

Filed:

Mar 4, 2004

Appl. No.:

10/795554

Inventors:

Wenyuan Shi - Los Angeles CA, US
Li Chen - Los Angeles CA, US
Qing-yi Lu - Los Angeles CA, US
David Heber - Los Angeles CA, US
Maxwell H. Anderson - Seattle WA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 31/58
A61K 31/70
A01N 43/04
C07J 71/00

US Classification:

514172, 514 27, 540 17

Abstract:

The present invention is based on the discovery that certain chemical compounds isolated from Chinese medicinal herbs are useful as anti-microbial agents, e. g. , anti-bacterial agents, anti-fungal agents, and the like. In particular, the present invention provides compositions useful for treating microbial infections such as, for example, oral microbial infections, including periodontal disease and dental caries.

US Patent:

20020068066, Jun 6, 2002

Filed:

Jun 15, 2001

Appl. No.:

09/881823

Inventors:

Wenyuan Shi - Los Angeles CA, US
Sherie Morrison - Los Angeles CA, US
Kham Trinh - Alhambra CA, US
Letitia Wims - Culver City CA, US
Li Chen - Los Angeles CA, US
Maxwell Anderson - Seattle WA, US

International Classification:

A61K039/09

US Classification:

424/185100, 424/244100

Abstract:

Dental caries in man may be prevented or treated by oral ingestion of human or humanized murine monoclonal IgG and IgM antibodies that bind to surface antigens of cariogenic organisms, such as . The genetically engineered monoclonal antibodies engage the effector apparatus of the human immune system when they bind to cariogenic organisms, resulting in their destruction. In a preferred embodiment, monoclonal antibodies to cariogenic organisms are produced by edible plants, including fruits and vegetables, transformed by DNA sequences that code on expression for the desired antibodies. The antibodies are applied by eating the plants.

US Patent:

20030143234, Jul 31, 2003

Filed:

Feb 14, 2002

Appl. No.:

10/077624

Inventors:

Wenyuan Shi - Los Angeles CA, US
Sherie Morrison - Los Angeles CA, US
Kham Trinh - Alhambra CA, US
Letitia Wims - Culver City CA, US
Li Chen - Los Angeles CA, US
Maxwell Anderson - Seattle WA, US
Fengxia Qi - Harbor City CA, US

International Classification:

A61K039/40
C07K016/46

US Classification:

424/178100, 530/391100

Abstract:

The present invention is based on the discovery of a composition that provides targeted anti-microbial effect. Specifically the composition contains a targeting moiety which recognizes a target microbial organism and an anti-microbial peptide moiety which has anti-microbial activity. In addition, the present invention provides methods of treating a microbial infection, e.g., on mucosal surfaces by using the compositions provided by the present invention.

US Patent:

20030228379, Dec 11, 2003

Filed:

May 28, 2002

Appl. No.:

10/156278

Inventors:

Wenyuan Shi - Los Angeles CA, US
Li Chen - Los Angeles CA, US
Maxwell Anderson - Seattle WA, US

International Classification:

A61K035/78

US Classification:

424/725000

Abstract:

The present invention provides compositions of herbs and methods of using the compositions for treating and preventing microbial infection, especially dental caries or periodontal disease.

US Patent:

20030229000, Dec 11, 2003

Filed:

Jun 6, 2002

Appl. No.:

10/164446

Inventors:

Justin Merritt - Los Angeles CA, US
Wenyuan Shi - Los Angeles CA, US
Maxwell Anderson - Seattle WA, US

International Classification:

A61K038/16
A01N061/00
A61K007/28

US Classification:

514/001000, 514/002000, 424/050000

Abstract:

The present invention is based on the discovery that interspecies quorum sensing is related to biofilm formation. The present invention provides methods useful for treating or preventing biofilm formation and microbial infections associated with biofilm formation by using an agent that either increases LuxS-dependent pathway or interspecies quorum sensing signal. The present invention also provides compositions containing an anti-micorbial agent and an agent that either increases LuxS-dependent pathway or interspecies quorum sensing signal.

US Patent:

20040052814, Mar 18, 2004

Filed:

Jul 19, 2001

Appl. No.:

09/910358

Inventors:

Wenyuan Shi - Los Angeles CA, US
Sherie Morrison - Los Angeles CA, US
Kham Trinh - Alhambra CA, US
Letitia Wims - Culver City CA, US
Li Chen - Los Angeles CA, US
Maxwell Anderson - Seattle WA, US

International Classification:

A61K039/02
A61K039/002
C07K014/44
C07K014/195
C07K014/39
C07K014/375

US Classification:

424/190100, 424/191100, 530/350000

Abstract:

Microbial infection may be treated by administration of a fusion protein comprising one or more recognition sequences and at least one antimicrobial peptide. In preferred embodiments, a linker peptide connects the recognition sequence and one or more antimicrobial peptides. The recognition sequence may be an immunoglobulin molecule, or fragment thereof, that specifically binds to a target antigen present on a pathogen. The recognition sequence may also be a non-immunological polypeptide, providing that the polypeptide binds specifically to a particular ligand. In presently preferred embodiments the recognition sequence is monoclonal antibody that binds specifically to and the antimicrobial peptides are derivatives of histatin.

US Patent:

20050255128, Nov 17, 2005

Filed:

Jan 26, 2005

Appl. No.:

11/044285

Inventors:

Justin Merritt - Los Angeles CA, US
Wenyuan Shi - Los Angeles CA, US
Maxwell Anderson - Seattle WA, US

Assignee:

The Regents of the University of California - Oakland CA
C3 Scientific Corporation - Seattle WA

International Classification:

A61K039/40
A61K039/02
A61K031/43
A61K031/497
A61K031/496
A61K038/14

US Classification:

424200100, 514008000, 514192000, 514200000, 514253080

Abstract:

The present invention is based on the discovery that interspecies quorum sensing is related to biofilm formation. The present invention provides methods useful for treating or preventing biofilm formation and microbial infections associated with biofilm formation by using an agent that either increases LuxS-dependent pathway or interspecies quorum sensing signal. The present invention also provides compositions containing an anti-micorbial agent and an agent that either increases LuxS-dependent pathway or interspecies quorum sensing signal.