Maxwell S Anderson

US Patent:

7569542, Aug 4, 2009

Filed:

Nov 12, 2003

Appl. No.:

10/706391

Inventors:

Randal Eckert - Los Angeles CA, US
Fengxia Qi - Harbor City CA, US
Wenyuan Shi - Los Angeles CA, US
Maxwell H. Anderson - Seattle WA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 38/16
A61K 38/00
C07K 4/04

US Classification:

514 12, 514 13, 514 14, 530300, 530324, 530326, 530327

Abstract:

The present invention is based on the discovery of a composition that provides targeted anti-microbial effect. Specifically the composition contains a targeting moiety which recognizes a target microbial organism and an anti-microbial peptide moiety which has anti-microbial activity. In addition, the present invention provides methods of treating a microbial infection, e. g. , on mucosal surfaces by using the compositions provided by the present invention.

US Patent:

7713927, May 11, 2010

Filed:

Jan 15, 2008

Appl. No.:

12/014634

Inventors:

Jian He - Los Angeles CA, US
Randal H. Eckert - Ellensburg WA, US
Fengxia Qi - Laguna Niguel CA, US
Maxwell H. Anderson - Sequim WA, US
Wenyuan Shi - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA
C3 Jian, Inc. - Sequim WA

International Classification:

A61K 38/00

US Classification:

514 2

Abstract:

This invention provides novel antimicrobial peptides that are effective to inhibit growth and/or proliferation of various gram positive bacteria. In particular, the peptides are effective against a common oral pathogen and the causative agent of dental caries.

US Patent:

7875598, Jan 25, 2011

Filed:

Mar 4, 2004

Appl. No.:

10/795554

Inventors:

Wenyuan Shi - Los Angeles CA, US
Li Chen - Los Angeles CA, US
Qing-yi Lu - Los Angeles CA, US
David Heber - Los Angeles CA, US
Maxwell H. Anderson - Seattle WA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 31/58
A61K 31/70
A01N 43/04
C07J 71/00

US Classification:

514172, 514 27, 540 17

Abstract:

The present invention is based on the discovery that certain chemical compounds isolated from Chinese medicinal herbs are useful as anti-microbial agents, e. g. , anti-bacterial agents, anti-fungal agents, and the like. In particular, the present invention provides compositions useful for treating microbial infections such as, for example, oral microbial infections, including periodontal disease and dental caries.

US Patent:

8303962, Nov 6, 2012

Filed:

Jan 6, 2010

Appl. No.:

12/683188

Inventors:

Randal H. Eckert - Redondo Beach CA, US
Chris Kaplan - Los Angeles CA, US
Jian He - Los Angeles CA, US
Daniel K. Yarbrough - Los Angeles CA, US
Maxwell Anderson - Sequim WA, US
Jee-Hyun Sim - Garden Grove CA, US

Assignee:

C3 Jian, Inc. - Inglewood CA

International Classification:

A61K 38/00
A61K 38/04
A61K 39/00
A61K 39/02
A61K 39/09
A61K 39/38
C07K 4/00
C07K 5/00
C07K 7/00

US Classification:

4242441, 4241841, 4241851, 4241901, 4242341, 4242371, 4242821, 530300, 530326, 930 10, 930 20, 930 21, 930200

Abstract:

This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various bacteria, yeast, and fungi.

US Patent:

8389679, Mar 5, 2013

Filed:

Feb 5, 2010

Appl. No.:

12/701443

Inventors:

Randal H. Eckert - Redondo Beach CA, US
Daniel Yarbrough - Los Angeles CA, US
Wenyuan Shi - Los Angeles CA, US
Maxwell Anderson - Sequim WA, US
Jian He - Los Angeles CA, US
Chris Kaplan - Los Angeles CA, US
Jee-Hyun Sim - Garden Grove CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 39/395

US Classification:

530324, 4241341, 435 34, 514 213

Abstract:

This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.

US Patent:

8609608, Dec 17, 2013

Filed:

Mar 24, 2010

Appl. No.:

12/730939

Inventors:

Jian He - Los Angeles CA, US
Randal H. Eckert - Ellensburg WA, US
Fengxia Qi - Laguna Niguel CA, US
Maxwell H. Anderson - Sequim WA, US
Wenyuan Shi - Los Angeles CA, US

Assignee:

C3 Jian, Inc. - Sequim WA
The Regents of the University of California - Oakland CA

International Classification:

A61K 38/10
A61K 38/04
A61K 38/16

US Classification:

514 26, 514 23, 514 24, 514 214, 514 215, 530324, 530325, 530326, 530327

Abstract:

This invention provides novel antimicrobial peptides that are effective to inhibit growth and/or proliferation of various gram positive bacteria. In particular, the peptides are effective against a common oral pathogen and the causative agent of dental caries.

US Patent:

20020068066, Jun 6, 2002

Filed:

Jun 15, 2001

Appl. No.:

09/881823

Inventors:

Wenyuan Shi - Los Angeles CA, US
Sherie Morrison - Los Angeles CA, US
Kham Trinh - Alhambra CA, US
Letitia Wims - Culver City CA, US
Li Chen - Los Angeles CA, US
Maxwell Anderson - Seattle WA, US

International Classification:

A61K039/09

US Classification:

424/185100, 424/244100

Abstract:

Dental caries in man may be prevented or treated by oral ingestion of human or humanized murine monoclonal IgG and IgM antibodies that bind to surface antigens of cariogenic organisms, such as . The genetically engineered monoclonal antibodies engage the effector apparatus of the human immune system when they bind to cariogenic organisms, resulting in their destruction. In a preferred embodiment, monoclonal antibodies to cariogenic organisms are produced by edible plants, including fruits and vegetables, transformed by DNA sequences that code on expression for the desired antibodies. The antibodies are applied by eating the plants.

US Patent:

20030143234, Jul 31, 2003

Filed:

Feb 14, 2002

Appl. No.:

10/077624

Inventors:

Wenyuan Shi - Los Angeles CA, US
Sherie Morrison - Los Angeles CA, US
Kham Trinh - Alhambra CA, US
Letitia Wims - Culver City CA, US
Li Chen - Los Angeles CA, US
Maxwell Anderson - Seattle WA, US
Fengxia Qi - Harbor City CA, US

International Classification:

A61K039/40
C07K016/46

US Classification:

424/178100, 530/391100

Abstract:

The present invention is based on the discovery of a composition that provides targeted anti-microbial effect. Specifically the composition contains a targeting moiety which recognizes a target microbial organism and an anti-microbial peptide moiety which has anti-microbial activity. In addition, the present invention provides methods of treating a microbial infection, e.g., on mucosal surfaces by using the compositions provided by the present invention.