- TAMPA FL, US PATRICIA D. LAWMAN - TEMPLE TERRACE FL, US VIJAY RAMIYA - TAMPA FL, US MEGHAN GENTILINI - ST. PETERSBURG FL, US
International Classification:
A61K 39/00 A61K 45/06 A61K 39/09
Abstract:
Customized whole cell cancer vaccines can be produced from autologous (ex vivo or in situ) or allogeneic human or veterinary patient cell lines. Cells are transformed with DNA that expresses an Emm protein on the cell surface and cytosol. Treatment of cancer patients with an Emm vector vaccine induces an immunologic response to the cancer by enhancing immunogenicity of a tumor. Emm vaccines can be used in patients where the cancer is not identified due to lower tumor burden or used to treat a specific cancer and subsequently treat for a second type that may have arisen through metastasis.
- TAMPA FL, US Patricia D. Lawman - Temple Terrace FL, US Vijay Ramiya - Tampa FL, US Meghan Gentilini - Tampa FL, US
International Classification:
A61K 39/00 A61K 45/06 A61K 39/09
Abstract:
Customized whole cell cancer vaccines can be produced from autologous (ex vivo or in situ) or allogeneic human or veterinary patient cell lines. Cells are transformed with DNA that expresses an Emm protein on the cell surface and cytosol. Treatment of cancer patients with an Emm vector vaccine induces an immunologic response to the cancer by enhancing immunogenicity of a tumor. Emm vaccines can be used in patients where the cancer is not identified due to lower tumor burden or used to treat a specific cancer and subsequently treat for a second type that may have arisen through metastasis.
- Tampa FL, US PATRICIA D. LAWMAN - TEMPLE TERRACE FL, US MEGHAN GENTILINI - TAMPA FL, US VIJAY RAMIYA - TAMPA FL, US MARINA VICTOR ABDELMASEEH BASTAWROUS - PORT ORANGE FL, US MICHAEL J. SHAMBLOTT - ST. PETERSBURG FL, US
International Classification:
A61K 39/00 A61K 45/06
Abstract:
Synthetic bacterial messenger RNA can be used to prepare autologous, allogenic or direct nucleic acid cancer vaccines. Cancer cells are transfected either in vitro or in vivo with mRNA obtained from DNA that encodes an immunogenic bacterial protein. An immune response to the cancer is generated from direct administration of the mRNA in vivo or administration of vaccines prepared from cancer cells in vitro.
- TAMPA FL, US PATRICIA D. LAWMAN - TEMPLE TERRACE FL, US MEGHAN GENTILINI - TAMPA FL, US VIJAY RAMIYA - TAMPA FL, US MARINA VICTOR ABDELMASEEH BASTAWROUS - PORT ORANGE FL, US
International Classification:
A61K 39/00 A61K 45/06 A61K 48/00
Abstract:
Synthetic bacterial messenger RNA can be used to prepare autologous, allogenic or direct nucleic acid cancer vaccines. Cancer cells are transfected either in vitro or in vivo with mRNA obtained from DNA that encodes an immunogenic bacterial protein. An immune response to the cancer is generated from direct administration of the mRNA in vivo or administration of vaccines prepared from cancer cells in vitro.