Mei C Chen

US Patent:

20230092150, Mar 23, 2023

Filed:

Nov 28, 2022

Appl. No.:

18/070021

Inventors:

- Wilmington DE, US
Mei Chen - Philadelphia PA, US
Michael J. Fevola - Belle Meade NJ, US
Gary Mosser - Tabernacle NJ, US
Brittany Pease - Philadelphia PA, US

International Classification:

A61K 8/44
A61K 8/64
A61K 8/81
A61Q 5/12

Abstract:

The invention described herein includes a self-neutralizing amino acid-based cationic composition that contains an amino acid-based cationic ester, a nonionic amphiphile, and an anhydrous buffering agent. In an embodiment, the composition, when dispersed or dissolved in an aqueous solvent, provides a resultant solution/dispersion having a pH of greater than about 4. The amino acid-based cationic ester may be a reaction product of (i) an amino acid having a non-polar side chain, and an amine group that has been neutralized with an acid; with (ii) a long chain fatty alcohol. Also included within the scope of the invention are methods of preparing a self-neutralizing amino acid-based cationic composition, such method including combining an amino acid-based cationic ester, a nonionic amphiphile and an anhydrous buffering agent. The resulting composition is in an anhydrous solid form. Formulations containing the amino acid-based cationic ester and/or a composition that includes it, are also disclosed.

US Patent:

20200281830, Sep 10, 2020

Filed:

Mar 9, 2020

Appl. No.:

16/813475

Inventors:

- Wilmington PA, US
Mei Chen - Philadelphia PA, US
Michael J. Fevola - Belle Mead NJ, US
Gary Mosser - Tabernacle NJ, US
Brittany Pease - Philadelphia PA, US

Assignee:

Inolex Investment Corporation - Wilmington DE

International Classification:

A61K 8/44
A61K 8/64
A61Q 5/12
A61K 8/81

Abstract:

The invention described herein includes a self-neutralizing amino acid-based cationic composition that contains an amino acid-based cationic ester, a nonionic amphiphile, and an anhydrous buffering agent. In an embodiment, the composition, when dispersed or dissolved in an aqueous solvent, provides a resultant solution/dispersion having a pH of greater than about 4. The amino acid-based cationic ester may be a reaction product of (i) an amino acid having a non-polar side chain, and an amine group that has been neutralized with an acid; with (ii) a long chain fatty alcohol. Also included within the scope of the invention are methods of preparing a self-neutralizing amino acid-based cationic composition, such method including combining an amino acid-based cationic ester, a nonionic amphiphile and an anhydrous buffering agent. The resulting composition is in an anhydrous solid form. Formulations containing the amino acid-based cationic ester and/or a composition that includes it, are also disclosed.

Address:

2532 Condor Dr, Audubon, PA 19403

Phone:

6106312716

VIN:

4JGBB8GB0BA736082

Make:

MERCEDES-BENZ

Model:

M-CLASS

Year:

2011