Melissa Reynolds

US Patent:

8034384, Oct 11, 2011

Filed:

Nov 21, 2007

Appl. No.:

11/944034

Inventors:

Mark E. Meyerhoff - Ann Arbor MI, US
Melissa M. Reynolds - Ann Arbor MI, US
Megan Frost - Ypsilanti MI, US
Sangyeul Hwang - Ann Arbor MI, US
Yiduo Wu - Ann Arbor MI, US

Assignee:

The Regents of The University of Michigan - Ann Arbor MI

International Classification:

A61K 33/34
A61K 38/44
A61F 2/00
C12N 11/00
C12N 11/02
C12N 11/08
C12N 9/04

US Classification:

424630, 424 944, 424423, 424426, 424600, 435174, 435176, 435177, 435180, 435189

Abstract:

A material includes a surface and a reactive agent that is located at the surface of the material, covalently attached to a backbone of the material, and/or located within the material. The reactive agent has nitrite reductase activity, nitrate reductase activity, and/or nitrosothiol reductase activity. The reactive agent also converts at least one of nitrites, nitrates and nitrosothiols to nitric oxide when in contact with blood. A reproducible nitrosothiol sensor is also disclosed.

US Patent:

20040224868, Nov 11, 2004

Filed:

Mar 5, 2004

Appl. No.:

10/794878

Inventors:

Mark Meyerhoff - Ann Arbor MI, US
Melissa Reynolds - Ann Arbor MI, US
Bong Oh - Chapel Hill NC, US
Wansik Cha - Ann Arbor MI, US
Megan Frost - Ypsilanti MI, US
Sangyeul Hwang - Ann Arbor MI, US
Sylvie Sim - Ann Arbor MI, US
Yiduo Wu - Ann Arbor MI, US

International Classification:

C12N009/06
C11D007/42
C11D003/386

US Classification:

510/320000, 435/191000

Abstract:

A material includes a surface and a reactive agent that is located at the surface of the material, covalently attached to a backbone of the material, and/or located within the material. The reactive agent has nitrite reductase activity, nitrate reductase activity, and/or nitrosothiol reductase activity. The reactive agent also converts at least one of nitrites, nitrates and nitrosothiols to nitric oxide when in contact with blood. A reproducible nitrosothiol sensor is also disclosed.

US Patent:

20060008529, Jan 12, 2006

Filed:

Jul 12, 2004

Appl. No.:

10/889646

Inventors:

Mark Meyerhoff - Ann Arbor MI, US
Melissa Reynolds - Ann Arbor MI, US
Zhenghong Zhou - Ann Arbor MI, US

International Classification:

A61K 9/14
A61K 31/21

US Classification:

424486000, 514509000

Abstract:

A method for increasing, prolonging, and/or controlling the release rates of nitric oxide (NO) from polymeric materials containing NO adducts. Such NO-containing polymeric materials may find use in devices such as blood contacting devices, and biocompatible devices utilizing the same. The method and device utilizes anionic site additives, acidic site additives and/or acidic producing site additives in a polymer that contains NO-adducts to generate higher fluxes of NO to exceed NO threshold levels desirable to substantially prevent and/or minimize reactions such as platelet activation or adhesion.

US Patent:

20060039950, Feb 23, 2006

Filed:

Aug 23, 2004

Appl. No.:

10/924102

Inventors:

Zhengrong Zhou - Ann Arbor MI, US
Mark Meyerhoff - Ann Arbor MI, US
Melissa Reynolds - Ann Arbor MI, US

International Classification:

A61K 31/727
A61K 31/655
A61F 2/00

US Classification:

424423000, 514056000, 514149000

Abstract:

A polymeric coating is adapted to substantially eliminate thrombus formation when in contact with blood. The polymeric coating includes a first polymeric layer and a second polymeric layer. Interposed between the first and second polymeric layers is a polymeric matrix layer doped with at least one of a nitric oxide donor and a nitric oxide generator. The nitric oxide donor and/or the nitric oxide generator are capable of releasing or generating NO. A bioactive agent is either immobilized to the surface of the second polymeric layer or is incorporated into the polymeric matrix layer.

US Patent:

20080241208, Oct 2, 2008

Filed:

Jun 30, 2006

Appl. No.:

11/994004

Inventors:

Charles Shanley - Grosse Pointe Farms MI, US
Scott Merz - Ann Arbor MI, US
Melissa M. Reynolds - Ann Arbor MI, US

International Classification:

A61K 9/00
A61F 2/02
A61K 33/00
A61K 38/20
A61P 9/10

US Classification:

424423, 623 146, 424718, 424 852

Abstract:

This disclosure is, at least in part, directed to compositions, devices, and methods of promote angiogenesis.

US Patent:

20080262330, Oct 23, 2008

Filed:

Jun 30, 2006

Appl. No.:

11/994003

Inventors:

Melissa M. Reynolds - Ann Arbor MI, US
Scott Merz - Ann Arbor MI, US
Cortney White - Belleville MI, US

International Classification:

A61B 5/1486

US Classification:

600347

Abstract:

The present invention relates to analyte sensors and compositions, membranes for use in analyte sensors. For example, an analyte sensor is provided that comprise an electrode surface comprising an enzyme; an a biocompatible analyte permeable composition comprising a nitric oxide generating agent.

US Patent:

20090118819, May 7, 2009

Filed:

Jun 30, 2006

Appl. No.:

11/994007

Inventors:

Scott Merz - Ann Arbor MI, US
Melissa M. Reynolds - Ann Arbor MI, US
Mark E. Meyerhoff - Ann Arbor MI, US
Joerg Lahann - Ann Arbor MI, US
Himabindu Nandivada - Ann Arbor MI, US
Sangyeul Hwang - Ann Arbor MI, US

International Classification:

A61F 2/06
A61M 25/00
A61N 1/05

US Classification:

623 142, 604265, 623 146, 607120

Abstract:

The disclosure provides for devices and coatings that are substantially free of organic solvent sand suitable for insertion into a patient, and that comprise a metal layer and a coating with a thickness of about 20 nm to about 2000 nm wherein the coating comprises a biocompatible polymer comprising at least one residue covalently bonded to a nitric oxide generating compound.

US Patent:

20090287072, Nov 19, 2009

Filed:

Dec 1, 2006

Appl. No.:

12/095656

Inventors:

Mark E. Meyerhoff - Ann Arbor MI, US
Wansik Cha - Ann Arbor MI, US
Melissa M. Reynolds - Ann Arbor MI, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI
MICHIGAN CRITICAL CARE CONSULTANTS, INC. (MC3) - Ann Arbor MI

International Classification:

A61M 37/00
A61L 27/34
A61L 27/54
A61P 9/00
A61B 5/1473

US Classification:

600345, 523112, 424424, 604502

Abstract:

The disclosure provides for a biocompatible, thromboresistant coating including a chalcogenide compound that induces nitric oxide formation; and a biocompatible matrix incorporating the chalcogenide compound. Devices incorporating such coatings, and methods of making and using such coatings are also disclosed herein.