Meng Jiu Chen

US Patent:

7410992, Aug 12, 2008

Filed:

Aug 31, 2004

Appl. No.:

10/569921

Inventors:

Meng Hsin Chen - Westfield NJ, US
James B. Doherty - Montvale NJ, US
Luping Liu - Plainsboro NJ, US
Swaminathan Natarajan - Scotch Plains NJ, US
Robert M. Tynebor - Woodbridge NJ, US

Assignee:

Merck & Co. Inc. - Rahway NJ

International Classification:

A61K 31/416
C07D 231/54

US Classification:

514406, 5483581, 5483601, 5483611, 5483615, 514403

Abstract:

This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans, or a pharmaceutically acceptable salt, in vivo hydrolysable ester, enantiomer, diastereomer or mixture thereof: formula (II) represents Caryl or Cheterocyclyl, said aryl or heterocyclyl optionally substituted with 1-3 groups selected from R; Z represents (CH)PO(OR)(OR*).

US Patent:

7494983, Feb 24, 2009

Filed:

Aug 31, 2004

Appl. No.:

10/570231

Inventors:

Meng Hsin Chen - Westfield NJ, US
James B. Doherty - Montvale NJ, US
Luping Liu - Plainsboro NJ, US
Swaminathan Natarajan - Scotch Plains NJ, US
Robert M. Tynebor - Woodbridge NJ, US

Assignee:

Merck & Co. Inc. - Rahway NJ

International Classification:

A61K 31/675
A61K 31/4439
C07F 9/06

US Classification:

514 80, 514 89, 514338, 514406, 546 22, 546 24, 548113

Abstract:

This invention relates to potent potassium channel blocker compounds of structural Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

US Patent:

8216679, Jul 10, 2012

Filed:

Mar 16, 2006

Appl. No.:

11/376999

Inventors:

Meng Chen - Novi MI, US
Steven M. Gasworth - Novi MI, US
Sunitha Grandhee - Novi MI, US
Johathan Ross Sargent - Kingston, CA

Assignee:

Exatec LLC - Wixom MI

International Classification:

B32B 27/28
B32B 27/36

US Classification:

428412, 428447, 428448, 428480

Abstract:

A glazing system and method for vehicle tops and windows is described therein. The system includes a panel having a top side and a bottom side, a first protective coating deposited on the top side and second protective coating deposited on the bottom side. The protective coatings provide protection from weathering and abrasion.

US Patent:

20050256117, Nov 17, 2005

Filed:

Jun 11, 2003

Appl. No.:

10/511636

Inventors:

Meng Hsin Chen - Westfield NJ, US
Luping Liu - Palainsboro NJ, US
Peter Meinke - Plainfield NJ, US
Ravi Natarajan - Scotch Plains NJ, US
William Parsons - Belle Mead NJ, US
Min Shu - Green Brook NJ, US
John Stelmach - Westfield NJ, US
Harold Wood - Westfield NJ, US
Fengqi Zhang - Edison NJ, US
David Wisnoski - Lansdale PA, US
James Doherty - Montvale NJ, US

International Classification:

A61K031/5377
A61K031/4439
A61K031/427
C07D417/02
C07D413/02
C07D043/02

US Classification:

514233500, 514370000, 548181000, 514337000, 546270700, 544143000

Abstract:

This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

US Patent:

20060148805, Jul 6, 2006

Filed:

Jun 25, 2004

Appl. No.:

10/561571

Inventors:

Meng Hsin Chen - Westfield NJ, US
James Doherty - Montvale NJ, US
Luping Liu - Plainsboro NJ, US
Swaminathan Natarajan - Scotch Plains NJ, US
Min Shu - Greenbrook NJ, US

International Classification:

A61K 31/522
A61K 31/503
A61K 31/498
A61K 31/4184
C07D 473/10
C07D 471/02
C07D 487/02

US Classification:

514248000, 514249000, 514263380, 514303000, 514394000, 544236000, 544276000, 544330000, 546117000, 548305400

Abstract:

This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

US Patent:

20060204746, Sep 14, 2006

Filed:

Feb 23, 2006

Appl. No.:

11/360547

Inventors:

Chengtao Li - Novi MI, US
Jonathan Sargent - Ann Arbor MI, US
Steven Gasworth - Farmington Hills MI, US
Meng Chen - Novi MI, US

International Classification:

B32B 5/16
B32B 27/36
B32B 27/30
B32B 27/06

US Classification:

428332000, 428411100, 428412000, 428522000, 428480000, 264138000, 264255000

Abstract:

A plastic panel and method of application for vehicle windows is disclosed. The plastic panel includes: a base layer; a weatherable film layer having a first and second surface, wherein the first surface of the film layer is adhered to the base layer; and an abrasion resistant layer adhered to the second surface of the weatherable film layer. The abrasion resistant layer is useful for protecting the weatherable film and base layers from damage caused by abrasion.

US Patent:

20070286966, Dec 13, 2007

Filed:

Jun 9, 2006

Appl. No.:

11/423269

Inventors:

Meng Chen - Novi MI, US
Chengtao Li - Novi MI, US

International Classification:

B05D 3/00
B05D 1/36
H05H 1/24
B05D 3/02

US Classification:

427569, 427299, 427402, 427384

Abstract:

A method for applying an abrasion resistant layer via a vacuum deposition technique to a plastic automotive window is provided. The plastic automotive window includes a plastic panel, an electroluminescent layer, and a weatherable layer. A first abrasion resistant sub-layer is then deposed on top of the weatherable layer, and a second abrasion resistant sub-layer is then applied onto the first abrasion resistant sub-layer. The deposition of the abrasion resistant sub-layers is carried out under controlled temperature conditions that reduce adhesion loss within the electroluminescent layer and maintains the electroluminescent functionality of that layer.

US Patent:

20080166569, Jul 10, 2008

Filed:

Dec 19, 2007

Appl. No.:

11/960193

Inventors:

Steven M. Gasworth - Novi MI, US
Sunitha Grandhee - Novi MI, US
Meng Chen - Novi MI, US
Mark A. Peters - Kingsport TN, US

Assignee:

Exatec, L.L.C. - Wixom MI

International Classification:

B32B 27/40
B05D 5/00

US Classification:

4284231, 427161

Abstract:

A plastic glazing system having weatherable coating for automotive windows is disclosed. The system comprises a transparent plastic substrate comprising an inner surface and an outer surface. The system further comprises a first weathering layer disposed on the outer surface of the substrate. The weathering layer comprises one of a polyurethane and a polyurethane-acrylate. The first weathering layer has a predetermined glass transition temperature. The system further comprises a first abrasion-resistant layer disposed on the first weathering layer. The first abrasion-resistant layer is compatible with the one of a polyurethane and a polyurethane-acrylate.