Meng N Chen

US Patent:

6613432, Sep 2, 2003

Filed:

Dec 21, 2000

Appl. No.:

09/746234

Inventors:

Paul O. Zamora - Gaithersburg MD
Shigemasa Osaki - Sandy UT
Meng Chen - Salt Lake City UT

Assignee:

BioSurface Engineering Technologies, Inc. - College Park MD

International Classification:

B32B 1504

US Classification:

428409, 427 224, 427539, 428457, 428469, 428544, 428685

Abstract:

Coatings, devices and methods are provided, wherein the contacting surface of a medical device with at least one contacting surface for contacting a bodily fluid or tissue is modified by plasma treatment in a plasma comprising nitrogen-containing molecules and oxygen-containing molecules. The nitrogen-containing molecules include NH , (NH ) , N O, NO, NO and N O , and the oxygen-containing molecules include O and O. The plasma-modified contacting surface exhibits decreased adhesion of at least some mammalian cells, such as platelets and leukocytes, decreased restenosis when used with stents, and increased apoptosis. Additional layers may be applied, including plasma polymerized hydrocyclosiloxane monomers, amine-providing groups such as N-trimethylsilyl-allylamine, polyoxyalkylene tethers, and bioactive compounds.

US Patent:

7410992, Aug 12, 2008

Filed:

Aug 31, 2004

Appl. No.:

10/569921

Inventors:

Meng Hsin Chen - Westfield NJ, US
James B. Doherty - Montvale NJ, US
Luping Liu - Plainsboro NJ, US
Swaminathan Natarajan - Scotch Plains NJ, US
Robert M. Tynebor - Woodbridge NJ, US

Assignee:

Merck & Co. Inc. - Rahway NJ

International Classification:

A61K 31/416
C07D 231/54

US Classification:

514406, 5483581, 5483601, 5483611, 5483615, 514403

Abstract:

This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans, or a pharmaceutically acceptable salt, in vivo hydrolysable ester, enantiomer, diastereomer or mixture thereof: formula (II) represents Caryl or Cheterocyclyl, said aryl or heterocyclyl optionally substituted with 1-3 groups selected from R; Z represents (CH)PO(OR)(OR*).

US Patent:

7494983, Feb 24, 2009

Filed:

Aug 31, 2004

Appl. No.:

10/570231

Inventors:

Meng Hsin Chen - Westfield NJ, US
James B. Doherty - Montvale NJ, US
Luping Liu - Plainsboro NJ, US
Swaminathan Natarajan - Scotch Plains NJ, US
Robert M. Tynebor - Woodbridge NJ, US

Assignee:

Merck & Co. Inc. - Rahway NJ

International Classification:

A61K 31/675
A61K 31/4439
C07F 9/06

US Classification:

514 80, 514 89, 514338, 514406, 546 22, 546 24, 548113

Abstract:

This invention relates to potent potassium channel blocker compounds of structural Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

US Patent:

7684587, Mar 23, 2010

Filed:

Apr 4, 2006

Appl. No.:

11/396911

Inventors:

Meng Chen - Frederick MD, US
George Bailey - Gaithersburg MD, US

Assignee:

Spirent Communications of Rockville, Inc. - Rockville MD

International Classification:

G06K 9/00
H04N 7/12

US Classification:

382100, 37524027

Abstract:

A method and system of communicating visual communication quality information, includes extracting reduced-reference (RR) feature data from visual content, embedding the RR feature data in the visual content; and transmitting the visual content with the embedded RR feature data. Visual communication quality is assessed by receiving visual content which includes visual content data and a first set of embedded RR feature data, retrieving the first set of RR feature data from the visual content data, and generating a second set of RR feature data from the visual content data. The second set of RR feature data corresponds to substantially identical features of the visual content data as that used to generate the first set of RR feature data. The first set of RR feature data is compared to the second first set of RR feature data to determine a quality of the visual content based upon the comparison.

US Patent:

7720131, May 18, 2010

Filed:

Jun 27, 2007

Appl. No.:

11/769537

Inventors:

Vikash Srivastava - Boyds MD, US
Meng Chen - Frederick MD, US

Assignee:

PC-Tel, Inc. - Bloomingdale IL

International Classification:

H04L 27/30

US Classification:

375144, 375148, 375349, 375365, 370503, 455 6711, 4552261

Abstract:

A method and apparatus are provided for decoding a wireless signal from a set of samples with an embedded training sequence. The method includes the steps of determining a first frequency offset from the samples where the first frequency offset is assumed to be less than a Nyquist frequency of the training sequence and calculating a first carrier to interference ratio based upon the first frequency offset. The method further includes the steps of determining a second frequency offset from the samples by subtracting an absolute value of the first frequency offset from an integer multiple of the Nyquist frequency and giving the second frequency offset a sign opposite that of the first frequency offset, calculating a second carrier to interference ratio based upon the second frequency offset and selecting one of the first and second frequency offsets based upon a relative values of the calculated carrier to interference ratios.

US Patent:

20050256117, Nov 17, 2005

Filed:

Jun 11, 2003

Appl. No.:

10/511636

Inventors:

Meng Hsin Chen - Westfield NJ, US
Luping Liu - Palainsboro NJ, US
Peter Meinke - Plainfield NJ, US
Ravi Natarajan - Scotch Plains NJ, US
William Parsons - Belle Mead NJ, US
Min Shu - Green Brook NJ, US
John Stelmach - Westfield NJ, US
Harold Wood - Westfield NJ, US
Fengqi Zhang - Edison NJ, US
David Wisnoski - Lansdale PA, US
James Doherty - Montvale NJ, US

International Classification:

A61K031/5377
A61K031/4439
A61K031/427
C07D417/02
C07D413/02
C07D043/02

US Classification:

514233500, 514370000, 548181000, 514337000, 546270700, 544143000

Abstract:

This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

US Patent:

20060148805, Jul 6, 2006

Filed:

Jun 25, 2004

Appl. No.:

10/561571

Inventors:

Meng Hsin Chen - Westfield NJ, US
James Doherty - Montvale NJ, US
Luping Liu - Plainsboro NJ, US
Swaminathan Natarajan - Scotch Plains NJ, US
Min Shu - Greenbrook NJ, US

International Classification:

A61K 31/522
A61K 31/503
A61K 31/498
A61K 31/4184
C07D 473/10
C07D 471/02
C07D 487/02

US Classification:

514248000, 514249000, 514263380, 514303000, 514394000, 544236000, 544276000, 544330000, 546117000, 548305400

Abstract:

This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

US Patent:

20100254568, Oct 7, 2010

Filed:

Mar 22, 2010

Appl. No.:

12/729175

Inventors:

Meng Chen - Frederick MD, US
George Bailey - Gaithersburg MD, US

Assignee:

Spirent Communications, Inc. - Sunnyvale CA

International Classification:

G06K 9/00
H04N 7/12

US Classification:

382100, 37524027, 375E07076

Abstract:

A method and system of communicating visual communication quality information, includes extracting reduced-reference (RR) feature data from visual content, embedding the RR feature data in the visual content; and transmitting the visual content with the embedded RR feature data. Visual communication quality is assessed by receiving visual content which includes visual content data and a first set of embedded RR feature data, retrieving the first set of RR feature data from the visual content data, and generating a second set of RR feature data from the visual content data. The second set of RR feature data corresponds to substantially identical features of the visual content data as that used to generate the first set of RR feature data. The first set of RR feature data is compared to the second first set of RR feature data to determine a quality of the visual content based upon the comparison.