Meng Chen

US Patent:

7410992, Aug 12, 2008

Filed:

Aug 31, 2004

Appl. No.:

10/569921

Inventors:

Meng Hsin Chen - Westfield NJ, US
James B. Doherty - Montvale NJ, US
Luping Liu - Plainsboro NJ, US
Swaminathan Natarajan - Scotch Plains NJ, US
Robert M. Tynebor - Woodbridge NJ, US

Assignee:

Merck & Co. Inc. - Rahway NJ

International Classification:

A61K 31/416
C07D 231/54

US Classification:

514406, 5483581, 5483601, 5483611, 5483615, 514403

Abstract:

This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans, or a pharmaceutically acceptable salt, in vivo hydrolysable ester, enantiomer, diastereomer or mixture thereof: formula (II) represents Caryl or Cheterocyclyl, said aryl or heterocyclyl optionally substituted with 1-3 groups selected from R; Z represents (CH)PO(OR)(OR*).

US Patent:

7494983, Feb 24, 2009

Filed:

Aug 31, 2004

Appl. No.:

10/570231

Inventors:

Meng Hsin Chen - Westfield NJ, US
James B. Doherty - Montvale NJ, US
Luping Liu - Plainsboro NJ, US
Swaminathan Natarajan - Scotch Plains NJ, US
Robert M. Tynebor - Woodbridge NJ, US

Assignee:

Merck & Co. Inc. - Rahway NJ

International Classification:

A61K 31/675
A61K 31/4439
C07F 9/06

US Classification:

514 80, 514 89, 514338, 514406, 546 22, 546 24, 548113

Abstract:

This invention relates to potent potassium channel blocker compounds of structural Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

US Patent:

20050256117, Nov 17, 2005

Filed:

Jun 11, 2003

Appl. No.:

10/511636

Inventors:

Meng Hsin Chen - Westfield NJ, US
Luping Liu - Palainsboro NJ, US
Peter Meinke - Plainfield NJ, US
Ravi Natarajan - Scotch Plains NJ, US
William Parsons - Belle Mead NJ, US
Min Shu - Green Brook NJ, US
John Stelmach - Westfield NJ, US
Harold Wood - Westfield NJ, US
Fengqi Zhang - Edison NJ, US
David Wisnoski - Lansdale PA, US
James Doherty - Montvale NJ, US

International Classification:

A61K031/5377
A61K031/4439
A61K031/427
C07D417/02
C07D413/02
C07D043/02

US Classification:

514233500, 514370000, 548181000, 514337000, 546270700, 544143000

Abstract:

This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

US Patent:

20060148805, Jul 6, 2006

Filed:

Jun 25, 2004

Appl. No.:

10/561571

Inventors:

Meng Hsin Chen - Westfield NJ, US
James Doherty - Montvale NJ, US
Luping Liu - Plainsboro NJ, US
Swaminathan Natarajan - Scotch Plains NJ, US
Min Shu - Greenbrook NJ, US

International Classification:

A61K 31/522
A61K 31/503
A61K 31/498
A61K 31/4184
C07D 473/10
C07D 471/02
C07D 487/02

US Classification:

514248000, 514249000, 514263380, 514303000, 514394000, 544236000, 544276000, 544330000, 546117000, 548305400

Abstract:

This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

US Patent:

59655658, Oct 12, 1999

Filed:

Dec 11, 1997

Appl. No.:

8/988816

Inventors:

Meng H. Chen - Westfield NJ
Zhijian Lu - Scotch Plains NJ
Ravi Nargund - East Brunswick NJ
Arthur A. Patchett - Westfield NJ
James R. Tata - Westfield NJ
Lihu Yang - Edison NJ
Mu Tsu Wu - Clark NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D20904
C07D21100
A61K 31445

US Classification:

514278

Abstract:

The present invention is directed to certain piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein B is selected from: ##STR2## and R. sup. 1, R. sup. 1a, R. sup. 2a, R. sup. 3a, R. sup. 3b, R. sup. 4, R. sup. 4a, R. sup. 4b, R. sup. 4c, R. sup. 5, D, X, Y, n, x and y are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

US Patent:

6121325, Sep 19, 2000

Filed:

Mar 27, 1997

Appl. No.:

8/826290

Inventors:

Meng Hsin Chen - Westfield NJ
Gregori J. Morriello - Belleville NJ
Ravi Nargund - East Brunswick NJ
Arthur A. Patchett - Westfield NJ
Lihu Yang - Edison NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31165
C07C23722

US Classification:

514616

Abstract:

The present invention is directed to certain compounds of the general structural formula: ##STR1## wherein R. sub. 1, R. sub. 1a, R. sub. 2a, R. sub. 3, R. sub. 3a, R. sub. 4, R. sub. 5, R. sub. 6, A, W, and n are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

US Patent:

57212511, Feb 24, 1998

Filed:

Feb 13, 1996

Appl. No.:

8/600912

Inventors:

Meng H. Chen - Westfield NJ
Ravi Nargund - East Brunswick NJ
Arthur A. Patchett - Westfield NJ
Lihu Yang - Edison NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31445
C07D40102
C07D40114
C07D40902

US Classification:

514318

Abstract:

The present invention is directed to certain novel compounds identified as substituted piperidines, pyrrolidines and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein R. sub. 1, R. sub. 4, R. sub. 5, A, X, Y and n are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

US Patent:

54929202, Feb 20, 1996

Filed:

Oct 17, 1994

Appl. No.:

8/323998

Inventors:

Meng H. Chen - Westfield NJ
Ravi Nargund - East Brunswick NJ
Arthur A. Patchett - Westfield NJ
Lihu Yang - Edison NJ

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

A61K 31445
C07D40106
C07D20904

US Classification:

514323

Abstract:

The present invention is directed to certain novel compounds identified as substituted piperidines, pyrrolidines and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein R. sub. 1, R. sub. 4, R. sub. 5, A, X, Y and n are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.