Meng Xiaowen Chen

US Patent:

6613432, Sep 2, 2003

Filed:

Dec 21, 2000

Appl. No.:

09/746234

Inventors:

Paul O. Zamora - Gaithersburg MD
Shigemasa Osaki - Sandy UT
Meng Chen - Salt Lake City UT

Assignee:

BioSurface Engineering Technologies, Inc. - College Park MD

International Classification:

B32B 1504

US Classification:

428409, 427 224, 427539, 428457, 428469, 428544, 428685

Abstract:

Coatings, devices and methods are provided, wherein the contacting surface of a medical device with at least one contacting surface for contacting a bodily fluid or tissue is modified by plasma treatment in a plasma comprising nitrogen-containing molecules and oxygen-containing molecules. The nitrogen-containing molecules include NH , (NH ) , N O, NO, NO and N O , and the oxygen-containing molecules include O and O. The plasma-modified contacting surface exhibits decreased adhesion of at least some mammalian cells, such as platelets and leukocytes, decreased restenosis when used with stents, and increased apoptosis. Additional layers may be applied, including plasma polymerized hydrocyclosiloxane monomers, amine-providing groups such as N-trimethylsilyl-allylamine, polyoxyalkylene tethers, and bioactive compounds.