Michael R Bittner

US Patent:

20080280777, Nov 13, 2008

Filed:

May 9, 2008

Appl. No.:

12/118352

Inventors:

Michael Bittner - Phoenix AZ, US
Edward R. Dougherty - College Station TX, US

Assignee:

Translational Genomics Research Institute - Phoenix AZ

International Classification:

C40B 30/04
C12Q 1/68
G06K 9/46
G06G 7/48

US Classification:

506 9, 435 6, 703 11, 382133

Abstract:

The present invention describes methods for carrying out experiments on living cells, including making measurements of the operation transcriptional regulatory processes and indicators of the kinds of processes operating in the cell in response to external stimuli. Image analysis allows for gathering data concerning the flow of information through a cell's genomic regulatory network as it is executing a programmatic change in its activities as a function of said stimuli. The method also allows collection of data of the results of the information-processing in the cell by observing the decisions the cell makes when modulating cellular process activities.

US Patent:

20100010797, Jan 14, 2010

Filed:

Jul 15, 2009

Appl. No.:

12/503787

Inventors:

Michael Bittner - Phoenix AZ, US
Edward R. Dougherty - College Station TX, US

Assignee:

Translational Genomics Research Institute - Phoenix AZ

International Classification:

G06G 7/48

US Classification:

703 11

Abstract:

The present invention describes methods for carrying out experiments on living cells, including making measurements of the operation transcriptional regulatory processes and indicators of the kinds of processes operating in the cell in response to external stimuli. Image analysis allows for gathering data concerning the flow of information through a cell's genomic regulatory network as it is executing a programmatic change in its activities as a function of said stimuli. The method also allows collection of data of the results of the information-processing in the cell by observing the decisions the cell makes when modulating cellular process activities.

US Patent:

20100144558, Jun 10, 2010

Filed:

Aug 24, 2007

Appl. No.:

12/438944

Inventors:

Frederic Zenhausern - Fountain Hills AZ, US
Christine Orozco - Mystic CT, US
Mark Richards - Maricopa AZ, US
Carl Yamashiro - Chandler AZ, US
Sally A. Amundson - New York NY, US
Ralf Lenigk - Tempe AZ, US
Michael L. Bittner - Phoenix AZ, US
Yoganand Balagurunathan - Tempe AZ, US

International Classification:

C40B 60/12

US Classification:

506 39

Abstract:

Exposure to ionizing radiation can produce a well-defined dose dependent signature in terms of changes in gene expression. In approaches and devices described herein, such a signature can be used to generate and use a self-contained radiation biodosimeter device, based on, for example, a blood finger stick. Various aspects of the invention are directed to biodosimetry with a fully integrated biochip using gene expression signatures.

US Patent:

20110217281, Sep 8, 2011

Filed:

Jul 21, 2009

Appl. No.:

13/055132

Inventors:

Jeffrey M. Trent - Phoenix AZ, US
Michael Bittner - Phoenix AZ, US
Edward R. Daugherty - College station TX, US
Yuan Jaing - Bethesda MD, US
Ronaldo Fumio - Sao Paulo, BR

International Classification:

A61K 38/46
C12Q 1/42
G01N 33/573
C40B 30/00
A61K 31/7088
A61K 38/22
A61P 35/00

US Classification:

424 946, 435 21, 435 74, 506 7, 514 44 R, 514 97

Abstract:

A method for diagnosing an early stage melanoma which includes detecting the expression level of dual specificity phosphatase 1 protein (DUSP1) and a method for determining a prognosis for a subject having melanoma which includes detecting the expression level of DUSP1 are disclosed. Also disclosed are pharmaceutical compositions and kits comprised by these methods.

US Patent:

20120264720, Oct 18, 2012

Filed:

Oct 14, 2011

Appl. No.:

13/274058

Inventors:

Michael Bittner - Phoenix AZ, US
Jeffrey M. Trent - Paradise Valley AZ, US

Assignee:

TRANSLATIONAL GENOMICS RESEARCH INSTITUTE - Phoenix AZ

International Classification:

A61K 31/6615
G01N 21/64
A61P 35/00
G01N 33/573
C40B 40/06
C12Q 1/68
C40B 30/04

US Classification:

514143, 435 611, 506 9, 435 74, 506 16

Abstract:

Methods of predicting whether or not a tumor will be responsive to IP6 treatment, methods of treating patients with cancer using IP6, methods of predicting the progression of a disease, and kits that facilitate these methods are disclosed.