Michael K Cerreta

US Patent:

20040229777, Nov 18, 2004

Filed:

Mar 25, 2004

Appl. No.:

10/809597

Inventors:

Michael Cerreta - Newtown CT, US
John Smoliga - Brookfield CT, US
Richard Varsolona - Scotch Plains NJ, US

Assignee:

Boehringer Ingelheim International GmbH - Ingelheim

International Classification:

A61K038/12
C07K005/12
A61K031/4709

US Classification:

514/010000, 514/312000, 530/317000

Abstract:

This invention relates to novel crystalline phases of the following Compound (1), methods for the preparation thereof, pharmaceutical compositions thereof, and their use in the treatment of Hepatitis C Viral (HCV) infection:

US Patent:

20050123665, Jun 9, 2005

Filed:

Jan 10, 2005

Appl. No.:

11/032360

Inventors:

Michael Cerreta - Newtown CT, US
Peter Lin - Middletown OH, US
Penelope Edwards - Greendale IN, US
Mark Agerton - Fairfield OH, US

International Classification:

A23L001/00

US Classification:

426531000

Abstract:

A flowable nondigestible oil composition having a Consistency in a temperature range of 20 C. to 40 C. of less than about 600 P.sec. The flowable nondigestible oil contains a liquid polyol polyester having a complete melt point less than 37 C., and a solid polyol polyester having a complete melt point of at least about 37 C., wherein the solid polyol polyester contains a solid saturated polyol polyester capable of forming crystallized spherulites. The flowable nondigestible oil is made by a process which includes the steps of melting completely the nondigestible oil, reducing the temperature of the melted nondigestible oil to a first crystallization temperature less than the onset crystallization temperature of the solid saturated polyol polyester, holding the nondigestible oil at the first crystallization temperature for a time sufficient to crystallize a portion of the solid saturated polyol polyester into crystallized spherulites, further reducing the temperature to an ambient crystallization temperature, and holding the polyol polyester composition for a time sufficient to crystallize the remaining portion of the solid polyol fatty acid polyester. The process is accompanied by shearing of the composition during the crystallization of the remaining portion of the solid polyol fatty acid polyester. The process is generally completed within 5 hours, usually within about 2 hours.

US Patent:

7276485, Oct 2, 2007

Filed:

Aug 19, 1997

Appl. No.:

08/914743

Inventors:

Michael Kenneth Cerreta - Newtown CT, US
Peter Yau-Tak Lin - Middletown OH, US
Penelope Marie Edwards - Greendale IN, US
Mark Lewis Agerton - Fairfield OH, US

Assignee:

The Procter + Gamble Co. - Cincinnati OH

International Classification:

A61K 31/70
A61K 31/715
C07H 13/02

US Classification:

514 23, 536115, 536119, 536124, 514 53, 562606, 554 1

Abstract:

A flowable nondigestible oil composition having a Consistency in a temperature range of 20 C. to 40 C. of less than about 600 P. sec. The flowable nondigestible oil contains a liquid polyol polyester having a complete melt point less than 37 C. , and a solid polyol polyester having a complete melt point of at least about 37 C. , wherein the solid polyol polyester contains a solid saturated polyol polyester capable of forming crystallized spherulites. The flowable nondigestible oil is made by a process which includes the steps of melting completely the nondigestible oil, reducing the temperature of the melted nondigestible oil to a first crystallization temperature less than the onset crystallization temperature of the solid saturated polyol polyester, holding the nondigestible oil at the first crystallization temperature for a time sufficient to crystallize a portion of the solid saturated polyol polyester into crystallized spherulites, further reducing the temperature to an ambient crystallization temperature, and holding the polyol polyester composition for a time sufficient to crystallize the remaining portion of the solid polyol fatty acid polyester. The process is accompanied by shearing of the composition during the crystallization of the remaining portion of the solid polyol fatty acid polyester. The process is generally completed within 5 hours, usually within about 2 hours.