Michael T Certo from Bozeman, MT, age 43

Coupling Endonucleases With End-Processing Enzymes Drives High Efficiency Gene Disruption
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US Patent:

20120276074, Nov 1, 2012
Filed:

Feb 24, 2012
Appl. No.:

13/405183
Inventors:

Andrew M. Scharenberg - Seattle WA, US
Michael T. Certo - Seattle WA, US
Kamila S. Gwiazda - Seattle WA, US
Assignee:

SEATTLE CHILDREN'S RESEARCH INSTITUTE - Seattle WA
International Classification:

C12N 9/96
A61P 37/02
A61P 31/18
C12N 15/90
A61K 38/46
US Classification:

424 942, 435188, 435462, 424 946
Abstract:

The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage.

Coupling Endonucleases With End-Processing Enzymes Drives High Efficiency Gene Disruption
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US Patent:

20210261946, Aug 26, 2021
Filed:

Apr 29, 2021
Appl. No.:

17/244190
Inventors:

- Seattle WA, US
Michael T. CERTO - Seattle WA, US
Kamila Sabina GWIAZDA - Seattle WA, US
Assignee:

SEATTLE CHILDREN'S HOSPITAL (dba SEATTLE CHILDREN'S RESEARCH INSTITUTE) - Seattle WA
International Classification:

C12N 15/10
A61K 9/00
C12N 15/62
A61K 35/28
A61K 38/45
A61K 38/46
A61K 38/52
C12N 9/12
C12N 9/22
C12N 9/90
Abstract:

The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage.

Coupling Endonucleases With End-Processing Enzymes Drives High Efficiency Gene Disruption
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US Patent:

20210254043, Aug 19, 2021
Filed:

Apr 29, 2021
Appl. No.:

17/244180
Inventors:

- Seattle WA, US
Michael T. CERTO - Seattle WA, US
Kamila Sabina GWIAZDA - Seattle WA, US
Assignee:

SEATTLE CHILDREN'S HOSPITAL (dba SEATTLE CHILDREN'S RESEARCH INSTITUTE) - Seattle WA
International Classification:

C12N 15/10
A61K 38/45
A61K 38/46
A61K 38/52
C12N 9/12
C12N 9/90
C12N 15/62
C12N 9/22
A61K 9/00
A61K 35/28
Abstract:

The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage.

Pcsk9 Endonuclease Variants, Compositions, And Methods Of Use
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US Patent:

20200376140, Dec 3, 2020
Filed:

Oct 4, 2018
Appl. No.:

16/753117
Inventors:

- Cambridge MA, US
KYLE HAVENS - SEATTLE WA, US
MICHAEL CERTO - MEDFORD MA, US
MAX ECHTERLING - BALTIMORE MD, US
Assignee:

bluebird bio, Inc. - Cambridge MA
International Classification:

A61K 48/00
A61P 3/06
C12N 15/63
C12N 15/90
C12N 9/22
C12N 9/64
Abstract:

The present disclosure provides improved genome editing compositions and methods for editing a PCSK9 gene. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of hypercholesterolemia or a condition associated therewith.

Multipartite Signaling Proteins And Uses Thereof
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US Patent:

20200071399, Mar 5, 2020
Filed:

Aug 14, 2019
Appl. No.:

16/540673
Inventors:

- Cambridge MA, US
Alexander Astrakhan - Seattle WA, US
Michael Certo - Medford MA, US
Assignee:

bluebird bio, Inc. - Cambridge MA
International Classification:

C07K 16/28
C07K 14/705
C07K 14/725
C07K 14/73
C07K 14/735
C12N 9/06
C12N 9/16
A61K 35/17
A61K 39/00
A61K 45/06
C07K 16/40
C12N 9/12
C12N 9/90
C12N 15/85
Abstract:

The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.

Multipartite Signaling Proteins And Uses Thereof
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US Patent:

20200071401, Mar 5, 2020
Filed:

Sep 17, 2019
Appl. No.:

16/573254
Inventors:

- Cambridge MA, US
Alexander ASTRAKHAN - Seattle WA, US
Michael CERTO - Medford MA, US
Assignee:

bluebird bio, Inc. - Cambridge MA
International Classification:

C07K 16/28
C12N 15/85
C07K 14/705
C12N 9/90
C12N 9/12
C07K 16/40
A61K 45/06
A61K 39/00
A61K 35/17
C12N 9/16
C12N 9/06
C07K 14/735
C07K 14/73
C07K 14/725
Abstract:

The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.

Multipartite Signaling Proteins And Uses Thereof
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US Patent:

20190112372, Apr 18, 2019
Filed:

Dec 13, 2018
Appl. No.:

16/219640
Inventors:

- Cambridge MA, US
Alexander ASTRAKHAN - Seattle WA, US
Michael CERTO - Medford MA, US
Assignee:

bluebird bio, Inc. - Cambridge MA
International Classification:

C07K 16/28
C07K 14/705
C12N 9/06
C12N 9/16
C12N 15/85
C07K 16/40
A61K 39/00
A61K 45/06
C12N 9/12
C12N 9/90
A61K 35/17
C07K 14/73
C07K 14/725
C07K 14/735
Abstract:

The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.

Coupling Endonucleases With End-Processing Enzymes Drives High Efficiency Gene Disruption
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US Patent:

20180320165, Nov 8, 2018
Filed:

May 25, 2018
Appl. No.:

15/990024
Inventors:

- Seattle WA, US
Michael T. Certo - Seattle WA, US
Kamila Sabina Gwiazda - Seattle WA, US
David J. Rawlings - Seattle WA, US
International Classification:

C12N 15/10
C12N 9/12
A61K 9/00
A61K 35/28
C12N 15/62
C12N 9/90
C12N 9/22
A61K 38/52
A61K 38/46
A61K 38/45
Abstract:

The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage.