Michael C Colvin

US Patent:

6477395, Nov 5, 2002

Filed:

Sep 14, 1999

Appl. No.:

09/395434

Inventors:

Joseph H. Schulman - Santa Clarita CA
Charles L. Byers - Canyon Country CA
Gerald E. Adomian - Los Angeles CA
Michael S. Colvin - Malibu CA

Assignee:

Medtronic MiniMed, Inc. - Northridge CA

International Classification:

A61B 500

US Classification:

600345, 600347, 600365

Abstract:

An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.

US Patent:

6512939, Jan 28, 2003

Filed:

Jun 27, 2000

Appl. No.:

09/604179

Inventors:

Michael S. Colvin - Malibu CA
Joseph H. Schulman - Santa Clarita CA
Lyle Dean Canfield - Lake Hughes CA
Rajiv Shah - Rancho Palos Verdes CA

Assignee:

Medtronic Minimed, Inc. - Northridge CA

International Classification:

A61B 505

US Classification:

600347, 600365, 600377

Abstract:

Improved implantable monitoring systems suitable for long-term in vivo use to measure the concentration of one or more prescribed substances, such as glucose, are described herein. In particular, an implantable enzyme-based glucose monitoring system is described that includes at least one of the following: means for replenishing the enzyme solution as it is consumed by the enzymatic reaction; means for replenishing the electrolyte solution bathing the electrode assembly; and microprocessing means proximal the electrode assembly. In preferred embodiments, a microprocessor assembly is hermetically associated with the substrate to which the electrode assembly is affixed. Further, the monitoring systems employ one or more reservoir systems in fluid communication with enzyme and electrolyte chambers wherein the enzyme and electrolyte solutions are used. In a further embodiment, the monitoring systems use enzyme and electrolyte reservoir bulbs in fluid communication with the enzyme and electrolyte reservoirs, respectively, and positioned near the skin surface, thereby providing ready access to the enzyme and electrolyte solutions without the need for explantation of the device. Further provided herein is an enzyme solution comprising microspheres in association with the enzyme; whereby the enzyme is immobilized by the microspheres and the microspheres are in a fluid, flowable solution.

US Patent:

6934572, Aug 23, 2005

Filed:

Oct 31, 2002

Appl. No.:

10/286174

Inventors:

Joseph H. Schulman - Santa Clarita CA, US
Charles L. Byers - Canyon Country CA, US
Gerald E. Adomian - Los Angeles CA, US
Michael S. Colvin - Malibu CA, US

Assignee:

Alfred E. Mann Foundation for Scientific Research - Santa Clarita CA

International Classification:

A61B005/00

US Classification:

600345, 600347, 600365, 204415

Abstract:

An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.

US Patent:

7706892, Apr 27, 2010

Filed:

Jan 20, 2005

Appl. No.:

11/040209

Inventors:

Michael Steven Colvin - Malibu CA, US
Tom Xiaohai He - Simi Valley CA, US
Matt Isaac Haller - Valley Village CA, US

Assignee:

Boston Scientific Neuromodulation Corporation - Valencia CA

International Classification:

A61B 5/042
A61B 1/05

US Classification:

607116, 600373

Abstract:

An implantable microstimulator includes a plastic housing having a first end and a second end; an electronic subassembly disposed within the housing; a first electrode disposed at the first end of the plastic housing and in electrical communication with the electronic subassembly; and a second electrode disposed at the second end of the plastic housing and in electrical communication with the electronic subassembly. The plastic housing, first electrode, and second electrode form a hermetically sealed structure around the electronic subassembly.

US Patent:

7722913, May 25, 2010

Filed:

Mar 31, 2005

Appl. No.:

11/096818

Inventors:

Joseph H. Schulman - Santa Clarita CA, US
Charles L. Byers - Canyon Country CA, US
Gerald E. Adomian - Los Angeles CA, US
Michael S. Colvin - Malibu CA, US

Assignee:

Alfred E. Mann Foundation for Scientific Research - Sylmar CA

International Classification:

A61L 33/00

US Classification:

427 21, 427 211, 427 212, 427 214, 427 221, 427 224, 427299, 427307, 4274301

Abstract:

An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.

US Patent:

7742817, Jun 22, 2010

Filed:

Mar 4, 2005

Appl. No.:

11/073290

Inventors:

Zdzislaw B. Malinowski - Castaic CA, US
Michael S. Colvin - Malibu CA, US
Leslie I. Halberg - Valencia CA, US

Assignee:

Boston Scientific Neuromodulation Corporation - Valencia CA

International Classification:

A61N 1/00

US Classification:

607 36

Abstract:

An implantable medical device, e. g. , an implantable pulse generator, having a non-metal sealed housing and method of making same. An exemplary embodiment of the device includes a replenishable power source, coupling electronic components configured to generate a pulse signal to the replenishable power source, and an inorganic coating covering the electronic components and the power source to seal, preferably hermetically, the electronic components and the power source from a body environment.

US Patent:

7771838, Aug 10, 2010

Filed:

Sep 29, 2005

Appl. No.:

11/238603

Inventors:

Tom Xiaohai He - Simi Valley CA, US
Michael S. Colvin - Malibu CA, US

Assignee:

Boston Scientific Neuromodulation Corporation - Valencia CA

International Classification:

B32B 15/04
B23K 103/08
B23K 103/14

US Classification:

428632, 428633, 428660, 428661, 428670

Abstract:

A component assembly for use in living tissue comprises: a ceramic part; a metal part; and a titanium palladium (Ti—Pd) interface layer for bonding said ceramic part to the metal part. In one embodiment, the interface layer may be formed from a single titanium layer in contact with a single palladium layer, or in other embodiments, may be at least a three layer laminate (Pd—Ti—Pd). A microstimulator housing comprising a ceramic part, a titanium or titanium alloy part sandwiching the Ti—Pd interlayer may be employed to create a eutectic bond that is strong and hermetic.

US Patent:

7949412, May 24, 2011

Filed:

Jun 1, 2006

Appl. No.:

11/421742

Inventors:

William Vanbrooks Harrison - Valencia CA, US
Michael S Colvin - Newbury Park CA, US
Janusz A Kuzma - Parker CO, US
Thomas J Balkany - Coral Gables FL, US

Assignee:

Advanced Bionics, LLC - Valencia CA

International Classification:

A61N 1/372

US Classification:

607137, 607116, 607117, 607136

Abstract:

Implantable electrode leads, e. g. cochlear, spinal cord stimulation, or any type of neurostimulation leads, used in a patient's body to stimulate muscle or nerve tissue, provide enhanced stimulation for treating, e. g. , hearing loss or chronic pain. One such lead includes, an implantable electrode array, adapted for insertion into a cochlea, which lead provides improved stability of electrode contact direction. In-line electrodes are spaced-apart along one side of a flexible carrier having non-conductive bumps coated with a bioresorbable material spaced apart between each electrode contact. Over time the bioresorbable material is absorbed thereby reducing chronic placement pressure caused during the insertion of the electrode array into the cochlea. The bioresorbable material may also serve as a carrier for drugs or other materials that would improve performance of the electrode for any type of lead.