Michael L Dillon

US Patent:

6599900, Jul 29, 2003

Filed:

May 10, 2002

Appl. No.:

10/143431

Inventors:

Hai-Ying Cai - Cupertino CA
Michael Patrick Dillon - San Carlos CA
Guido Galley - Rheinfelden, DE
Annick Goergler - Colmar, FR
Sabine Kolczewski - Rheinfelden, DE
Dawn Muszynski Barsy - Cupertino CA

Assignee:

Syntex (U.S.A.) LLC - Palo Alto CA

International Classification:

C07D49810

US Classification:

5142305, 544 91

Abstract:

The invention relates to compounds of the general formula wherein (R ) is independently from from each other halogen, lower alkyl or lower alkoxy; R is hydrogen, lower alkyl, lower halogen-alkyl, â(CH ) âOH, â(CH ) âNR , â(CH ) O-lower alkyl, â(CH ) âC(O)âNR , or is â(CH ) -6-membered heteroaryl, optionally substituted by one or more lower alkoxy, â(CH ) -5 or 6-membered not aromatic heterocyclyl, optionally substituted by hydroxy or lower alkyl; R is hydrogen or lower alkyl and may be the same or different in case of R ; n is 0, 1, or 2; m is 0, 1, 2, 3 or 4; and pharmaceutically acceptable acid addition salts thereof. These compounds have a good affinity to the NK-1 receptor and they are therefore suitable for the treatment of diseases, related to this receptor.

US Patent:

6756395, Jun 29, 2004

Filed:

Apr 22, 2003

Appl. No.:

10/421119

Inventors:

Michael Patrick Dillon - San Carlos CA
Clara Jeou Jen Lin - Palo Alto CA
Counde OYang - Sunnyvale CA
Xiaoming Zhang - Campbell CA

Assignee:

Roche Palo Alto LLC - Palo Alto CA

International Classification:

A61K 314178

US Classification:

514402, 514401, 5483551, 5483491, 5483114

Abstract:

Compounds of the Formula: where R -R are those defined herein and methods for producing the same. Also provided are pharmaceutical compositions comprising a Compound of Formula I and methods for their use as therapeutic agents.

US Patent:

6979696, Dec 27, 2005

Filed:

May 7, 2004

Appl. No.:

10/841288

Inventors:

Michael Patrick Dillon - San Carlos CA, US
Clara Jeou Jen Lin - Palo Alto CA, US
Amy Geraldine Moore - Mountain View CA, US
Counde O'Yang - Sunnyvale CA, US
Yansheng Zhai - East Palo Alto CA, US

Assignee:

Roche Palo Alto LLC - Palo Alto CA

International Classification:

A61K031/415
C07D233/64

US Classification:

514398, 514399, 514400, 5483395, 5483401, 5483411, 5483415, 5483421, 5483001

Abstract:

This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha-1A/L receptor agonists, and which are represented by Formula I: wherein m, A, X, Y, R, R, R, Rand Rare as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

US Patent:

7404154, Jul 22, 2008

Filed:

Jul 25, 2005

Appl. No.:

11/189026

Inventors:

Ramnath Venkatraman - San Jose CA, US
Michael N. Dillon - Richfield MN, US
David A. Gardner - Sudbury MA, US
Subramanian Ramesh - Cupertino CA, US
Robert C. Armstrong - North Andover MA, US
Gary Scott Delp - Rochester MN, US
Scott Allen Peterson - Bloomington MN, US

Assignee:

LSI Corporation - Milpitas CA

International Classification:

G06F 17/50

US Classification:

716 2, 716 1, 716 5

Abstract:

A basic cell circuit architecture having plurality of cells with fixed transistors configurable for the formation of logic devices and/or single/dual port memory devices within a structured ASIC is provided. Different configurations of ensuing integrated circuits are achieved by forming variable interconnect layers above the fixed structures. The circuit architecture can achieve interconnection of transistors within a single cell and/or across multiple cells. The interconnection can be configured to form basic logic gates as well as more complex digital and analog subsystems. In addition, each cell contains a layout of transistors that can be variably coupled to achieve a memory device, such as a SRAM device. By having the capability of forming either a logic circuit element, a memory device, or both, the circuit architecture is both memory-centric and logic-centric, and more fully adaptable to modern-day SoCs.

US Patent:

7407980, Aug 5, 2008

Filed:

Apr 13, 2004

Appl. No.:

10/823012

Inventors:

Michael Patrick Dillon - San Carlos CA, US
Clara Jeou Jen Lin - Palo Alto CA, US
Counde O'Yang - Sunnyvale CA, US
Xiaoming Zhang - Campbell CA, US

Assignee:

Roche Palo Alto LLC - Palo Alto CA

International Classification:

A61K 31/4174
C07D 233/24

US Classification:

514401, 5483551

Abstract:

Compounds of the Formula:.

US Patent:

7470684, Dec 30, 2008

Filed:

Dec 20, 2007

Appl. No.:

11/960765

Inventors:

Joanie Marie Caroon - Mountain View CA, US
Michael Patrick Dillon - San Francisco CA, US
Bo Han - Pudong, CN
Matthias Nettekoven - Grenzach-Wyhlen, DE
Hasane Ratni - Habsheim, FR
Walter Vifian - Olten, CH

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D 498/10
A61K 31/537

US Classification:

5142305, 544 71

Abstract:

The present invention relates to a compound of formula I.

US Patent:

7491821, Feb 17, 2009

Filed:

Aug 11, 2006

Appl. No.:

11/502797

Inventors:

Christine E. Brotherton-Pleiss - Sunnyvale CA, US
Michael Patrick Dillon - San Francisco CA, US
Shelley K. Gleason - Redwood City CA, US
Clara Jeou Jen Lin - Palo Alto CA, US
Ryan Craig Schoenfeld - San Jose CA, US
Marzia Villa - Sunnyvale CA, US
Yansheng Zhai - East Palo Alto CA, US

Assignee:

Roche Palo Alto LLC - Palo Alto CA

International Classification:

C07D 403/12
C07D 413/12
C07D 417/12
C07D 295/194

US Classification:

544295, 544121, 544357, 544364, 544369, 544371, 544386, 544391, 544362, 544237, 544250, 544330, 544331, 546209, 546212, 546214

Abstract:

Compounds of formula 1 are modulators of P2X3 useful for the treatment of pain and genitourinary, gastrointestinal, and respiratory disorders:.

US Patent:

8166440, Apr 24, 2012

Filed:

Jun 16, 2008

Appl. No.:

12/139974

Inventors:

Ramnath Venkatraman - San Jose CA, US
Michael N. Dillon - Richfield MN, US
David A. Gardner - Sudbury MA, US
Subramanian Ramesh - Cupertino CA, US
Robert C. Armstrong - North Andover MA, US
Gary Scott Delp - Rochester MN, US
Scott Allen Peterson - Bloomington MN, US

Assignee:

LSI Corporation - Milpitas CA

International Classification:

G06F 17/50

US Classification:

716122, 716118, 716119

Abstract:

A basic cell circuit architecture having plurality of cells with fixed transistors configurable for the formation of logic devices and/or single/dual port memory devices within a structured ASIC is provided. Different configurations of ensuing integrated circuits are achieved by forming variable interconnect layers above the fixed structures. The circuit architecture can achieve interconnection of transistors within a single cell and/or across multiple cells. The interconnection can be configured to form basic logic gates as well as more complex digital and analog subsystems. In addition, each cell contains a layout of transistors that can be variably coupled to achieve a memory device, such as a SRAM device. By having the capability of forming either a logic circuit element, a memory device, or both, the circuit architecture is both memory-centric and logic-centric, and more fully adaptable to modern-day SoCs.