Michael A Doherty

US Patent:

7728989, Jun 1, 2010

Filed:

Jul 27, 2007

Appl. No.:

11/829471

Inventors:

Michael Doherty - Peabody MA, US
Yitzhak Daniel - Givat Ze'ev, IL
Eli Zeitlin - Jerusalem, IL
Karol Sanilevici - Jerusalem, IL
Gabriel Y. Sirat - Jerusalem, IL
Gregory Agronik - Jerusalem, IL

Assignee:

Optimet, Optical Metrology Ltd. - Jerusalem

International Classification:

G01B 11/14

US Classification:

356614, 356622

Abstract:

Methods for digitizing complex surfaces of dental objects such as impressions of dental surfaces and shapes. While an impression mold is being scanned by translation along a known trajectory, typically in a plane, the line of sight of a distance probe is directed toward successive positions on the surface of the impression mold, such as by a periodic series of reflecting surfaces characterized by normal vectors at distinct non-orthogonal angles with respect to their axis of symmetry. One or more reference objects are scanned using the same translation and mirror positioning systems. Gathered coordinate data are processed to apply angular corrections and combined to form a single distortion-corrected image of the impression mold. An apparatus and methods are provided for measuring both sides of a dental object separately, and then registering the two sides relative to each other in a digital representation of the object.

US Patent:

20120236135, Sep 20, 2012

Filed:

Mar 13, 2012

Appl. No.:

13/418730

Inventors:

Yitzhak Daniel - Givat Ze'ev, IL
Karol Sanilevici - Jerusalem, IL
Michael Doherty - Peabody MA, US
Alex Entelis - Maale Edumim, IL

Assignee:

OPTIMET, OPTICAL METROLOGY LTD. - Jerusalem

International Classification:

H04N 7/18

US Classification:

348 66, 348E07085

Abstract:

Methods and apparatus for registration of digital images of a plurality of dental surfaces of a patient. Multiple dental surfaces are separately scanned and digitized, where each of the surfaces has at least one marked area. All marked areas are optically acquired, creating digitized images of the plurality of dental surfaces, which are then registered in a common reference frame on the basis of a specified marked areas. In some cases, a first dental surface is disposed on an upper dental arch and a second dental surface is disposed on a lower dental arch. Marked contact areas may be indicative of local occlusion pressure.

US Patent:

20220387906, Dec 8, 2022

Filed:

Mar 20, 2020

Appl. No.:

17/593613

Inventors:

- Cambridge MA, US
Michael DOHERTY - Somerville MA, US
Kimberly ELLIS - Somerville MA, US
Raymond BOURDEAU - Watertown MA, US
Kayla DESANTY - Bedford MA, US

Assignee:

Codiak BioSciences, Inc. - Cambridge MA

International Classification:

B01D 15/36
C12M 1/00

Abstract:

The present disclosure relates to multistep chromatographic methods for preparing extracellular vesicles (EVs). The methods were demonstrated to be effective in preparing highquality EVs in a large scale. The methods enable preparation of EVs for therapeutic and diagnostic applications, and isolation and/or sub-fractionation of EVs with desired properties for specific use.

US Patent:

20210093568, Apr 1, 2021

Filed:

Sep 8, 2020

Appl. No.:

17/014961

Inventors:

- Cambridge MA, US
Michael P. MERCALDI - Wilmington MA, US
Kathryn E. GOLDEN - Braintree MA, US
Raymond W. BOURDEAU - Watertown MA, US
Michael F. DOHERTY - Somerville MA, US
Konstantin KONSTANTINOV - Waban MA, US
Douglas E. WILLIAMS - Boston MA, US

International Classification:

A61K 9/127
C12N 15/113
C12N 15/11

Abstract:

Methods of loading extracellular vesicles with payload molecules via homogenization are disclosed herein.

US Patent:

20200306342, Oct 1, 2020

Filed:

Mar 16, 2020

Appl. No.:

16/819817

Inventors:

- Cambridge MA, US
Brett Boghigian - Boston MA, US
Caitlyn Harvey - Wilmington MA, US
David Berry - Brookline MA, US
David Young - Portsmouth NH, US
Geoffrey Von Maltzahn - Boston MA, US
John Kramarczyk - Somerville MA, US
Jameson Rogers - Cambridge MA, US
Kathryn Heard - Watertown MA, US
Michael Doherty - Somerville MA, US
Nathaniel Silver - Cambridge MA, US
Phillip Samayoa - Cambridge MA, US
Subhayu Basu - Chestnut Hill MA, US
Shaila Rahman - Cambridge MA, US
Vimal Vaidya - Watertown MA, US

International Classification:

A61K 38/17
G16B 20/00
A61K 38/00
A23L 33/00
A23L 33/17
A23L 33/18
A23L 33/175
A61K 38/38
A61K 9/00
A61K 9/14
A61K 9/20
A61K 9/28
G01N 33/68
A23L 2/66
A61K 38/16
A61K 45/06
A23L 33/195
A61K 38/10
A61K 38/45

Abstract:

Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.

US Patent:

20200188481, Jun 18, 2020

Filed:

Sep 27, 2019

Appl. No.:

16/585357

Inventors:

- Cambridge MA, US
Brett Boghigian - Boston MA, US
Caitlyn Harvey - Wilmington MA, US
David Berry - Brookline MA, US
David Young - Portsmouth NH, US
Geoffrey Von Maltzahn - Boston MA, US
John Kramarczyk - Somerville MA, US
Jameson Rogers - Cambridge MA, US
Kathryn Heard - Watertown MA, US
Michael Doherty - Somerville MA, US
Nathaniel Silver - Cambridge MA, US
Phillip Samayoa - Cambridge MA, US
Subhayu Basu - Chestnut Hill MA, US
Shaila Rahman - Cambridge MA, US
Vimal Vaidya - Watertown MA, US

International Classification:

A61K 38/17
G16B 20/00
A61K 38/00
A23L 33/00
A23L 33/17
A23L 33/18
A23L 33/175
A61K 38/38
A61K 9/00
A61K 9/14
A61K 9/20
A61K 9/28
G01N 33/68
A23L 2/66
A61K 38/16
A61K 45/06
A23L 33/195
A61K 38/10
A61K 38/45

Abstract:

Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.

US Patent:

20190344423, Nov 14, 2019

Filed:

May 8, 2018

Appl. No.:

15/974511

Inventors:

Robert James Doherty - Walpole MA, US
Michael Thomas Doherty - Newton MA, US
Charles Guaring - Newton MA, US

International Classification:

B25G 1/10
B25G 3/20

Abstract:

An ergonomic, multi-purpose, attachable and adjustable, auxiliary handle assembly that provides a single supplementary handle for multiple tools and implements. The handle assembly is comprised of an “L”-shaped cylindrical bar that is combined with an adjustable yet lockable, hinged clamp that can be conveniently positioned along the primary cylindrical shaft of elongated tools and implements. This adjustable placement of this new auxiliary handle provides greater convenience in utilizing the tool to maximize its leverage or lifting capability while reducing the risk of muscular strain and fatigue. The adjustable feature allows operators of different sizes; tall to short, to conveniently place the adjustable handle on their tool or implement, at a position on the elongated shaft, that maximizes their preferred handling of the tool for operation. This auxiliary handle allows the user to maximize the effective use of the tool while reducing arm and back strain or injury. In addition to the ergonomic benefits, this new auxiliary handle provides multiple functional benefits for more effective lifting, pulling and pushing operation of tools and implements. In addition, the auxiliary handle enables operational use of tools and implements, with all the above-mentioned benefits, for both day and night use, given the convenient optional lighting component attached to the “L”-shaped handle that sheds light on the tool or implement head (where the head is the shovel, rake, hoe, broom or other tool end attachment).

US Patent:

20190175506, Jun 13, 2019

Filed:

Nov 13, 2018

Appl. No.:

16/190058

Inventors:

- Cambridge MA, US
Michael P. Mercaldi - Wilmington MA, US
Kathryn E. Golden - Braintree MA, US
Raymond W. Bourdeau - Watertown MA, US
Michael F. Doherty - Somerville MA, US
Konstantin Konstantinov - Waban MA, US
Douglas E. Williams - Boston MA, US

International Classification:

A61K 9/127
C12N 15/113

Abstract:

Methods of loading extracellular vesicles with payload molecules via homogenization are disclosed herein.