Michael G Donovan

US Patent:

7723293, May 25, 2010

Filed:

Oct 30, 2006

Appl. No.:

11/589659

Inventors:

Barbara L. Hempstead - New York NY, US
Rosemary Kraemer - Brooklyn NY, US
Shahin Rafii - Great Neck NY, US
Phi Wiegn - New York NY, US
Michael L. Donovan - Brookline MA, US

Assignee:

Cornell Research Foundation, Inc. - Ithaca NY
Children's Medical Center Corporation - Boston MA

International Classification:

A61K 38/18

US Classification:

514 2, 514 12, 530399

Abstract:

The present invention relates to methods of inducing or inhibiting the angiogenic process and promoting vessel growth or stabilization in an organ by modulating the trk receptor pathway. The present invention also relates to a method for treating a pathological disorder in a patient which includes administering a trk receptor ligand or an inhibitor or expression or activity of a trk receptor ligand. The present invention also relates to a method of screening for a modulator of angiogenesis, vessel growth, or vessel stabilization. Another aspect of the present invention is a method of diagnosing or monitoring a pathological disorder in a patient which includes determining the presence or amount of a trk receptor ligand or activation of a trk receptor ligand in a biological sample.

US Patent:

7909247, Mar 22, 2011

Filed:

Apr 23, 2007

Appl. No.:

11/738823

Inventors:

David S. Bonalle - New Rochelle NY, US
Michael Donovan - Phoenix AZ, US
Sherrie Jackson - Phoenix AZ, US
Scott Paylor - Glendale AZ, US
Medina Senghore - Brentwood NY, US
Tracey Thomas - Boonton NJ, US

Assignee:

American Express Travel Related Services Company, Inc. - New York NY

International Classification:

G06K 5/00
G06F 17/00
G06Q 10/00

US Classification:

235380, 235375, 705 5

Abstract:

A wireless financial transaction instrument, such as a card, has a magnetic stripe, a display, and an on-board power supply, such as a battery, and is usable with a dual capture point of sale terminal. Information is received by such a terminal from the card wirelessly, and also from the magnetic stripe, and the data received contactlessly is preferably used to verify that read from the stripe. The display can display the account number on command, or to display a current balance, or amount of credit remaining, or any combination of these items of information.

US Patent:

8062897, Nov 22, 2011

Filed:

Apr 14, 2006

Appl. No.:

11/404272

Inventors:

Paola Capodieci - New York NY, US
Michael J. Donovan - Boston MA, US

Assignee:

Aureon Laboratories, Inc. - Yonkers NY

International Classification:

G01N 33/00
G01N 33/53
C07H 21/04

US Classification:

436 94, 436800, 536 231, 536 243

Abstract:

The present invention relates to a method for detecting one or more nascent RNAs in a tissue sample using FISH. In the method, a plurality of probes (8 to 82) may be used to detect a single species of nascent RNA. Further, a plurality of nascent RNA species may be detected simultaneously using between 8 and 82 probes for each nascent RNA. The invention comprises, in addition, methods of preparing a sample for nascent RNA detection by reducing autofluorescence of the tissue sample. These techniques may be synergistically combined to achieve significantly improved results.

US Patent:

8070058, Dec 6, 2011

Filed:

Feb 21, 2011

Appl. No.:

13/031548

Inventors:

David S. Bonalle - New Rochelle NY, US
Michael D. Donovan - Phoenix AZ, US
Sherrie G. Jackson - Phoenix AZ, US
Scott Glen Paylor - Glendale AZ, US
Medina J. Senghore - Brentwood NJ, US
Tracey R. Thomas - Boonton NJ, US

Assignee:

American Express Travel Related Services Company, Inc. - New York NY

International Classification:

G06K 19/00

US Classification:

235380, 235375, 235379

Abstract:

A wireless financial transaction instrument, such as a card, has a magnetic stripe, a display, and an on-board power supply, such as a battery, and is usable with a dual capture point of sale terminal. Information is received by such a terminal from the card wirelessly, and also from the magnetic stripe, and the data received contactlessly is preferably used to verify that read from the stripe. The display can display the account number on command, or to display a current balance, or amount of credit remaining, or any combination of these items of information.

US Patent:

8093012, Jan 10, 2012

Filed:

Oct 13, 2006

Appl. No.:

11/581043

Inventors:

Stefan Hamann - Yonkers NY, US
Michael Donovan - Cambridge MA, US
Mark Clayton - Pawling NY, US
Angeliki Kotsianti - New York NY, US

Assignee:

Aureon Laboratories, Inc. - Yonkers NY

International Classification:

G01N 33/533
G01N 33/543
G01N 33/563
G01N 33/567
G01N 33/574
G01N 33/577
C07K 16/18

US Classification:

435 723, 435 71, 435 72, 435 721, 435 724, 435 74, 435 78, 435 795, 435 405, 435 4052, 435960, 435962, 436503, 436512, 436518, 436548, 436 64, 436172, 436175

Abstract:

A method of in situ immunohistochemical analysis of a biological sample is provided. The method allows for the multiplex and simultaneous detection of multiple antigens, including multiple nuclear antigens, in a tissue sample.

US Patent:

8201733, Jun 19, 2012

Filed:

Oct 13, 2011

Appl. No.:

13/273144

Inventors:

David S. Bonalle - New Rochelle NY, US
Michael D. Donovan - Phoenix AZ, US
Sherrie G. Jackson - Phoenix AZ, US
Scott Glen Paylor - Glendale AZ, US
Medina J. Senghore - Brentwood NY, US
Tracey R. Thomas - Boonton NJ, US

Assignee:

American Express Travel Related Services Company, Inc. - New York NY

International Classification:

G06K 5/00

US Classification:

235380, 235375, 705 5

Abstract:

A wireless financial transaction instrument, such as a card, has a magnetic stripe, a display, and an on-board power supply, such as a battery, and is usable with a dual capture point of sale terminal. Information is received by such a terminal from the card wirelessly, and also from the magnetic stripe, and the data received contactlessly is preferably used to verify that read from the stripe. The display can display the account number on command, or to display a current balance, or amount of credit remaining, or any combination of these items of information.

US Patent:

8348159, Jan 8, 2013

Filed:

May 10, 2012

Appl. No.:

13/468211

Inventors:

David S. Bonalle - New Rochelle NY, US
Michael D. Donovan - Phoenix AZ, US
Sherrie G. Jackson - Phoenix AZ, US
Scott Glen Paylor - Glendale AZ, US
Medina J. Senghore - Brentwood NY, US
Tracey R. Thomas - Boonton NJ, US

Assignee:

American Express Travel Related Services Company, Inc. - New York NY

International Classification:

G06K 19/00

US Classification:

235380, 235375, 235379

Abstract:

A wireless financial transaction instrument, such as a card, has a magnetic stripe, a display, and an on-board power supply, such as a battery, and is usable with a dual capture point of sale terminal. Information is received by such a terminal from the card wirelessly, and also from the magnetic stripe, and the data received contactlessly is preferably used to verify that read from the stripe. The display can display the account number on command, or to display a current balance, or amount of credit remaining, or any combination of these items of information.

US Patent:

20100227823, Sep 9, 2010

Filed:

May 21, 2010

Appl. No.:

12/785183

Inventors:

Barbara L. HEMPSTEAD - New York NY, US
Rosemary KRAEMER - Brooklyn NY, US
Shahin RAFII - Great Neck NY, US
Phi WIEGN - New York NY, US
Michael J. DONOVAN - Brookline MA, US

Assignee:

CORNELL RESEARCH FOUNDATION, INC. - Ithaca NY
CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA

International Classification:

A61K 38/12
A61P 7/00

US Classification:

514 12

Abstract:

The present invention relates to methods of inducing or inhibiting the angiogenic process and promoting vessel growth or stabilization in an organ by modulating the trk receptor pathway. The present invention also relates to a method for treating a pathological disorder in a patient which includes administering a trk receptor ligand or an inhibitor or expression or activity of a trk receptor ligand. The present invention also relates to a method of screening for a modulator of angiogenesis, vessel growth, or vessel stabilization. Another aspect of the present invention is a method of diagnosing or monitoring a pathological disorder in a patient which includes determining the presence or amount of a trk receptor ligand or activation of a trk receptor ligand in a biological sample.