Michael J Draper

US Patent:

6841546, Jan 11, 2005

Filed:

Mar 14, 2002

Appl. No.:

10/097457

Inventors:

Michael Draper - Plaistow NH, US
Mark L. Nelson - Wellesley MA, US

Assignee:

Paratek Pharmaceuticals, Inc. - Boston MA

International Classification:

A61K 3165
A01N 3718

US Classification:

514152

Abstract:

Methods and compositions for treating fungal associated disorders in subjects are discussed.

US Patent:

7045507, May 16, 2006

Filed:

Mar 14, 2002

Appl. No.:

10/097634

Inventors:

Michael Draper - Plaistow NH, US
Mark L. Nelson - Wellesley MA, US

Assignee:

Paratek Pharmaceuticals, Inc. - Boston MA

International Classification:

A61K 31/70
A61K 31/65
A61K 31/415

US Classification:

514 31, 514152, 514394, 514395

Abstract:

Methods and compositions for treating for the synergistic treatment of fungal associated disorders are discussed.

US Patent:

7960366, Jun 14, 2011

Filed:

Sep 16, 2004

Appl. No.:

10/943571

Inventors:

Michael Draper - Plaistow NH, US
Mark L. Nelson - Norfolk MA, US

Assignee:

Paratek Pharmaceuticals, Inc. - Boston MA

International Classification:

A61K 31/65
A01N 37/18

US Classification:

514154

Abstract:

Methods and compositions for treating for the synergistic treatment of fungal associated disorders are discussed.

US Patent:

8088820, Jan 3, 2012

Filed:

Oct 24, 2003

Appl. No.:

10/692563

Inventors:

Michael Draper - Plaistow NH, US
Mark L. Nelson - Norfolk MA, US

Assignee:

Paratek Pharmaceuticals, Inc. - Boston MA

International Classification:

A61K 31/36
C07D 317/50
C07D 317/54
C07D 317/58

US Classification:

514464, 514441, 514452, 514466, 549443, 549444, 549446

Abstract:

This invention provides a method for treating or preventing malaria in a subject. The method includes administering to the subject an effective amount of a substituted tetracycline compound, such that malaria is treated or prevented. In one aspect, the invention relates to pharmaceutical compositions which include an effective amount of a tetracycline compound to treat malaria in a subject and a pharmaceutically acceptable carrier. The substituted tetracycline compounds of the invention can be used to in combination with one or more anti-malarial compounds or can be used to treat or prevent malaria which is resistant to one or more other anti-malarial compounds.

US Patent:

20040092490, May 13, 2004

Filed:

Apr 24, 2002

Appl. No.:

10/128990

Inventors:

Michael Draper - Plaistow NH, US
Mark Nelson - Wellesley MA, US

International Classification:

A61K031/65
A61K031/473
A61K031/353
A61K031/385

US Classification:

514/152000, 514/284000, 514/434000, 514/453000

Abstract:

This invention provides a method for treating or preventing malaria in a subject. The method includes administering to the subject an effective amount of a substituted tetracycline compound, such that malaria is treated or prevented. In one aspect, the invention relates to pharmaceutical compositions which include an effective amount of a tetracycline compound to treat malaria in a subject and a pharmaceutically acceptable carrier. The substituted tetracycline compounds of the invention can be used to in combination with one or more anti-malarial compounds or can be used to treat or prevent malaria which is resistant to one or more other anti-malarial compounds.

US Patent:

20050020545, Jan 27, 2005

Filed:

Aug 18, 2004

Appl. No.:

10/921580

Inventors:

Michael Draper - Plaistow NH, US
Mark Nelson - Norfolk MA, US

Assignee:

Paratek Pharmaceuticals, Inc. - Boston MA

International Classification:

A61K031/65

US Classification:

514152000

Abstract:

Methods and compositions for treating fungal associated disorders in subjects are discussed.

US Patent:

20080118979, May 22, 2008

Filed:

May 15, 2007

Appl. No.:

11/803854

Inventors:

Michael Draper - Plaistow NH, US
Mark L. Nelson - Norfolk MA, US

Assignee:

Paratek Pharmaceuticals, Inc. - Boston MA

International Classification:

C12N 5/02

US Classification:

435375

Abstract:

The present invention relates, at least in part, to the use of substituted tetracycline compounds for regulation of expression of nucleic acids operably linked to a tetracycline operator system. The invention pertains to compounds used in a regulatory system which utilizes components of the Tet repressor/operator/inducer system of prokaryotes to regulate gene expression in cells. Use of certain substituted tetracycline compounds, as featured in the methods of the invention, result in improved dose-response results when compared to those for e.g., tetracycline and doxycycline. Certain methods of the invention thus allow for enhanced control of the Tet repressor/operator/inducer system in regulating gene expression in cells.

US Patent:

20110245501, Oct 6, 2011

Filed:

Jun 14, 2011

Appl. No.:

13/160027

Inventors:

Michael Draper - Windham NH, US
Mark L. Nelson - Norfolk MA, US

Assignee:

Paratek Pharmaceuticals, Inc. - Boston MA

International Classification:

C07D 295/155
C07D 307/81
C07C 237/26
C07D 307/54
C07D 277/42
C07D 213/56

US Classification:

544380, 549469, 552203, 548528, 552205, 549496, 548194, 546285

Abstract:

The present invention relates to substituted tetracycline compounds and related methods for increasing the antifungal activity of an antifungal agent. The methods include administering to a subject an effective amount of a substituted tetracycline compound in combination with an antifungal agent such that the subject is treated for the fungal associated disorder.