Michael J Elliott

US Patent:

6569682, May 27, 2003

Filed:

Jul 27, 2001

Appl. No.:

09/917452

Inventors:

Michael Elliott - Fort Lauderdale FL
Dana B. Jacobs - Cooper City FL
Nery Ortiz - Miami FL
Wayne Goldson - Sunrise FL
Penny Whitley - Lawrenceville GA
Theodore J. Gerula - Fort Lauderdale FL

Assignee:

Coulter International Corp. - Miami FL

International Classification:

G01N 3100

US Classification:

436 10, 436 8, 436 16, 436 18, 436 63, 2524081, 435 2

Abstract:

An improved blood suspension media for hematological compositions, having particular utility with a red blood cell component for devices using electronic and optical means for blood determinations, and processes for using the suspension media. The suspension media finds particular utility in providing the hematology control product with a stable and consistent MCV and RDW for an extended product shelf life.

US Patent:

6869798, Mar 22, 2005

Filed:

Apr 17, 2003

Appl. No.:

10/418196

Inventors:

Harold Richardson Crews - Coral Springs FL, US
Michael N. Elliott - Fort Lauderdale FL, US

Assignee:

Clinical Diagnostics Solutions, Inc. - Plantation FL

International Classification:

G01N031/00
G01N033/48

US Classification:

436 10, 436 8, 436 17, 436 18, 436 63, 436164, 436166, 435 2, 435 29, 435 39, 2524081

Abstract:

A lytic reagent composition and the method of use for differential analysis of leukocytes using flow cytometry are disclosed. The lytic reagent composition includes a short chain alkyl oxyethanol, such as 2-methoxyethanol, 2-ethoxyethanol, 2-propoxyethanol, or 2-isopropoxyethanol, in a sufficient amount to preserve leukocytes; a non-lysing nonionic surfactant as a debris solublizer; and an inorganic buffer to maintain pH of the lytic reagent composition in a range from 9. 1 to 10. 7. The lytic reagent composition is used to lyse red blood cells and preserve leukocytes, as well as used as the sheath reagent for the focus flow measurement. The lytic reagent composition, when used on a flow cytometric analyzer with multiple angle light scatter and light absorbance measurements, enables differentiation of leukocytes into five subpopulations.

US Patent:

20050048656, Mar 3, 2005

Filed:

Aug 2, 2004

Appl. No.:

10/909561

Inventors:

Carole Young - Raleigh NC, US
Michael Elliott - Fort Lauderdale FL, US
Timothy Fischer - Raleigh NC, US

International Classification:

G01N033/48

US Classification:

436016000, 436063000

Abstract:

A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an instrument. The spatial position of a control product sample is analyzed. Alternatively, the spatial position of a statistically significant number of patient blood samples can be used. The method enables the monitoring of an instrument for problems associated with debris and noise caused by red cell lysis inefficiency; instrument reagents pump volume settings; instrument laser alignments: instrument gain settings; and flow noise caused by partial plugs, residual plugs or other flow problems. The method provides a more specific indication of the type and cause of an instrument malfunctioning than non specific flagging provided by prior art methods.

US Patent:

20050048657, Mar 3, 2005

Filed:

Aug 2, 2004

Appl. No.:

10/909594

Inventors:

Carole Young - Raleigh NC, US
Michael Elliott - Fort Lauderdale FL, US
Timothy Fischer - Raleigh NC, US

International Classification:

G01N033/48

US Classification:

436016000, 436063000, 436066000

Abstract:

A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an instrument. The spatial position of a control product sample is analyzed. Alternatively, the spatial position of a statistically significant number of patient blood samples can be used. The method enables the monitoring of an instrument for problems associated with debris and noise caused by red cell lysis inefficiency; instrument reagents pump volume settings; instrument laser alignments; instrument gain settings; and flow noise caused by partial plugs, residual plugs or other flow problems. The method provides a more specific indication of the type and cause of an instrument malfunctioning than non specific flagging provided by prior art methods.

US Patent:

20050095719, May 5, 2005

Filed:

Nov 24, 2004

Appl. No.:

10/996863

Inventors:

Carole Young - Raleigh NC, US
Michael Elliott - Fort Lauderdale FL, US
Timothy Fischer - Raleigh NC, US

International Classification:

G01N033/72

US Classification:

436066000

Abstract:

A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an instrument. The spatial position of a control product sample is analyzed. Alternatively, the spatial position of a statistically significant number of patient blood samples can be used. The method enables the monitoring of an instrument for problems associated with debris and noise caused by red cell lysis inefficiency; instrument reagents pump volume settings; instrument laser alignments; instrument gain settings; and flow noise caused by partial plugs, residual plugs or other flow problems. The method provides a more specific indication of the type and cause of an instrument malfunctioning than non specific flagging provided by prior art methods.

US Patent:

20050221496, Oct 6, 2005

Filed:

May 25, 2005

Appl. No.:

11/136889

Inventors:

Carole Young - Raleigh NC, US
Michael Elliott - Fort Lauderdale FL, US
Timothy Fischer - Raleigh NC, US

International Classification:

G01N033/48

US Classification:

436063000, 436016000

Abstract:

A method of quality control to diagnose the cause of a malfunction of an instrument. The method uses measurements of the physical property of a sample to diagnose the cause of a malfunction of an instrument. The spatial position of a control product sample is analyzed. Alternatively, the spatial position of a statistically significant number of patient blood samples can be used. The method enables the monitoring of an instrument for problems associated with debris and noise caused by red cell lysis inefficiency; instrument reagents pup volume settings; instrument laser alignments; instrument gain settings; and flow noise caused by partial plugs, residual plugs or other flow problems. The method provides a more specific indication of the type and cause of an instrument malfunctioning than non specific flagging provided by prior art methods.

US Patent:

53209648, Jun 14, 1994

Filed:

Jun 23, 1993

Appl. No.:

8/081752

Inventors:

Carole Young - Miami FL
Michael N. Elliott - Cooper City FL
Timothy J. Fischer - Raleigh NC
Nancy R. Naylor - Miramar FL

Assignee:

Coulter Corporation - Miami FL

International Classification:

G01N 3100

US Classification:

436 10

Abstract:

A hematology control product comprising leukocyte analogs is described. The analogs comprise red blood cells which simulate at least two physical properties of human leukocytes. A method for making leukocyte analogs from blood cells having desired physical properties is also described. The process comprises expanding the cell volume, changing the hemoglobin content of the cell and fixing the cell. Generally, the monocyte and lymphocyte analogs leak hemoglobin from the cell while the eosinophil analog has the hemoglobin precipitated in the cell. A further method is described to use the control product to determine whether an automatic instrument is operating within manufacturer's specification.

US Patent:

55299334, Jun 25, 1996

Filed:

Feb 8, 1995

Appl. No.:

8/386711

Inventors:

Carole Young - Miami FL
Michael N. Elliott - Cooper City FL
Nancy R. Naylor - Miramar FL
Timothy J. Fischer - Raleigh NC

Assignee:

Coulter Corporation - Miami FL

International Classification:

G01N 3396

US Classification:

436 10

Abstract:

A hematology control product comprising leukocyte analogs and an aqueous solution of a plasma substance for use in a blood counting instrument is described. The instrument employs a lytic reagent system for the lysable red blood cells in the control product. The plasma substance is in an amount effective to enable the differentiation of each of said leukocyte analogs relative to the physical attributes of the analogs, said physical attributes of the analog are similar to human leukocytes. Preferably, the plasma substance comprises cholesterol or its derivatives. A method for using the cell suspension media comprising an aqueous solution of a plasma substance is also described. The method provides a quality control to determine whether an instrument is operating within manufacturer's specifications.

Address:

640 NW 22 St, Wilton Manors, FL 33311

VIN:

JNRAS08U27X101628

Make:

INFINITI

Model:

FX35

Year:

2007