Michael R Emery

US Patent:

7219545, May 22, 2007

Filed:

Jul 28, 2004

Appl. No.:

10/900996

Inventors:

Philip E. Salzmann - Cardiff CA, US
Alec T. Harootunian - San Diego CA, US
Michael P. Emery - Santee CA, US
Javier H. Flores - San Diego CA, US
Todd N. Bennett - Philadelphia PA, US
Minh Vuong - San Diego CA, US

Assignee:

Vertex Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G01F 23/00
G01F 23/24
G01F 23/26

US Classification:

73304R, 73304 C, 73290 R

Abstract:

A liquid level sensor comprises a plurality of electrodes arranged in a defined relationship with respect to a container filling trajectory, a signal generator coupled to one or more of the plurality of electrodes, a signal receiver coupled to one or more of the plurality of electrodes, and a sensing circuit coupled to at least one of the signal generator and signal receiver. The sensing circuit is configured to produce an output indicative of electrical resistance between at least one pair of the plurality of electrodes. The sensing circuit may be associated with the signal receiver and/or with the signal generator.

US Patent:

7490513, Feb 17, 2009

Filed:

May 10, 2007

Appl. No.:

11/747142

Inventors:

Philip E. Salzmann - Cardiff CA, US
Alec T. Harootunian - San Diego CA, US
Michael P. Emery - Santee CA, US
Javier H. Flores - San Diego CA, US
Todd N. Bennett - San Diego CA, US
Minh Vuong - San Diego CA, US

Assignee:

Vertex Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G01F 23/00

US Classification:

73304R, 73304 C, 73290 R

Abstract:

A liquid level sensor comprises a plurality of electrodes arranged in a defined relationship with respect to a container filling trajectory, a signal generator coupled to one or more of the plurality of electrodes, a signal receiver coupled to one or more of the plurality of electrodes, and a sensing circuit coupled to at least one of the signal generator and signal receiver. The sensing circuit is configured to produce an output indicative of electrical resistance between at least one pair of the plurality of electrodes. The sensing circuit may be associated with the signal receiver and/or with the signal generator.

US Patent:

7919047, Apr 5, 2011

Filed:

Jun 5, 2006

Appl. No.:

11/446821

Inventors:

James E. Sinclair - Carlsbad CA, US
Michael P. Emery - Santee CA, US
Minh Vuong - San Diego CA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

B01L 3/02

US Classification:

422100, 7386332

Abstract:

An air displacement pipetter comprises a guidance sleeve positioned within a hole in a cylinder block and a piston within a portion of the guidance sleeve a piston penetrating the cylinder block, a spring energized seal disposed within the cylinder block, a seal capture plate contacting the spring energized seal, a carrier plate, a pipette tip attached to the carrier plate, and a manifold plate between said carrier plate and said cylinder block.

US Patent:

8337754, Dec 25, 2012

Filed:

Dec 22, 2009

Appl. No.:

12/644839

Inventors:

Michael P. Emery - Santee CA, US
Matthew C. Wallace - Carlsbad CA, US
James E. Sinclair - Carlsbad CA, US
Raymond J. Gonzales - Chula Vista CA, US
Brian Grot - San Diego CA, US
Sanjay S. Magavi - Cambridge MA, US

Assignee:

Vertex Pharmaceuticals, Incorporated - Cambridge MA

International Classification:

G01N 21/00

US Classification:

422 65, 422 63, 422 64, 422500

Abstract:

Disclosed herein are systems and methods for the developing of immuno-stained biological samples. The systems disclosed herein are automated and are configured to control one or more steps of the developing procedure. Reagents may be added using automatic syringe dispensing. Reagent temperature, reagent stirring, and wash procedures are programmable and can be separately controlled for separate immuno-staining procedures that are performed at the same time.

US Patent:

8353969, Jan 15, 2013

Filed:

May 25, 2012

Appl. No.:

13/480747

Inventors:

Jack Barger - Poway CA, US
James Sinclair - Carlsbad CA, US
Michael P. Emery - Santee CA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

B01D 9/00

US Classification:

23295R, 23306

Abstract:

Methods and devices for controlled evaporation of solvent from a solution are provided. In one embodiment, a method for controlled evaporation of solvent from at least one solution includes filling a selected first set of wells in a multi-well plate with a first solution comprising at least one first solvent. The method also includes attaching an inlet manifold to the plate, the inlet manifold comprising an inlet port connected to and in fluid communication only with each of the wells in the selected first set of wells. The method further includes attaching an exhaust manifold to the plate, the exhaust manifold comprising an exhaust port connected to and in fluid communication only with each of the wells in the selected first set of wells. The method also includes introducing a gas into the inlet port and removing solvent vapor from the selected first set of wells.

US Patent:

8206659, Jun 26, 2012

Filed:

Jun 12, 2009

Appl. No.:

12/483787

Inventors:

Jack Barger - Poway CA, US
James Sinclair - Carlsbad CA, US
Michael P. Emery - Santee CA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

B01D 9/00

US Classification:

4222451, 422648

Abstract:

Methods and devices for controlled evaporation of solvent from a solution are provided. In one embodiment, the device can control evaporation of different solutions comprising solvents of dissimilar volatilities simultaneously. In another embodiment, control over the flow of solvent vapor out of the device is provided by selecting the pressure at an inlet port and an exhaust port of the device. In yet another embodiment, control over the flow of solvent vapor out of the device is provided by selecting the size of a disk flow control orifice positioned between the wells and a vapor removal outlet of the device. In still another embodiment, control over the flow of solvent vapor out of the device is provided by the opening and closing of the vapor removal outlet of the device. In yet a further embodiment, the rate of evaporation of solvent is controlled by controlling the temperature of the solution. The flow rate control mechanisms can be used alone or in any combination to control evaporation of one or more solvents from solutions.

US Patent:

20150168277, Jun 18, 2015

Filed:

Feb 25, 2015

Appl. No.:

14/631586

Inventors:

- Cambridge MA, US
Jack Barger - Poway CA, US
Michael Paul Emery - Santee CA, US
James Edward Sinclair - Carlsbad CA, US
Jorge Arturo Ayala - San Diego CA, US

International Classification:

G01N 1/31

Abstract:

Disclosed herein are apparatuses and methods handling a portion of a tissue sample when sectioned by a microtome. The apparatuses include a container, a tissue sample holder in the container, and one or more outlets configured to allow flow of a fluid from the container. the flow through the outlet causes a portion of the tissue sample sectioned by a microtome to move into the outlet. The methods include sectioning one or more portions of a tissue sample, and flowing a fluid past the tissue sample to cause the one or more portions of the tissue sample to move away from the tissue sample and toward at least one fluid outlet.