Michael J Endres

US Patent:

7560534, Jul 14, 2009

Filed:

Nov 7, 2001

Appl. No.:

10/035637

Inventors:

Yashwant M. Deo - East Brunswick NJ, US
Tibor Keler - Ottsville PA, US
John Treml - Philadelphia PA, US
Michael Endres - Riegelsville PA, US

Assignee:

Celldex Research Corporation - Phillipsburg NJ

International Classification:

C07K 16/00
C12P 21/08

US Classification:

53038873

Abstract:

Molecular conjugates comprising an antigen linked to a human monoclonal antibody that specifically binds to dendritic cells are disclosed. Also disclosed are pharmaceutical compositions comprising the molecular conjugates and therapeutic methods for using the conjugates.

US Patent:

7763258, Jul 27, 2010

Filed:

Dec 21, 2001

Appl. No.:

10/032311

Inventors:

Robert Doms - Berwyn PA, US
Joseph Rucker - Philadelphia PA, US
Trevor L. Hoffman - Irvine CA, US
Paul Bates - Swarthmore PA, US
James Hoxie - Berwyn PA, US
Michael Endres - Painesville OH, US
John Balliet - Norristown PA, US
Dennis Kolson - Secane PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

A61K 39/12
A61K 39/205

US Classification:

4241991, 4242071, 4242081, 4242241

Abstract:

Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.

US Patent:

8142790, Mar 27, 2012

Filed:

Nov 26, 2008

Appl. No.:

12/324009

Inventors:

Yashwant M. Deo - East Brunswick NJ, US
Tibor Keler - Ottsville PA, US
John Treml - Philadelphia PA, US
Michael Endres - Painesville OH, US

Assignee:

Celldex Research Corporation - Phillipsburg NJ

International Classification:

A61K 39/00

US Classification:

4241921, 4241851

Abstract:

The present invention provides novel methods for targeting an antigen to a dendritic cell using an antibody linked to the antigen. The present invention further provides methods of inducing or enhancing an immune response and methods of immunization using an antibody linked to the antigen.

US Patent:

8158130, Apr 17, 2012

Filed:

Mar 9, 2010

Appl. No.:

12/720398

Inventors:

Robert W Doms - Berwyn PA, US
Joseph Rucker - Philadelphia PA, US
Trevor L Hoffman - Irvine CA, US
Paul Bates - Swarthmore PA, US
James A Hoxie - Berwyn PA, US
Michael J Endres - Painesville OH, US
John Balliet - Norristown PA, US
Dennis L Kolson - Secane PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia

International Classification:

A61K 39/12
C12P 21/06
C12N 15/00

US Classification:

4241991, 435 691, 4353201

Abstract:

Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.

US Patent:

20040248215, Dec 9, 2004

Filed:

Jan 30, 2004

Appl. No.:

10/769144

Inventors:

Tibor Keler - Ottsville PA, US
Michael Endres - Riegelsville PA, US
Lizhen He - Allentown PA, US
Venky Ramakrishna - Riegelsville PA, US

Assignee:

MEDAREX, INC. - Princeton NJ

International Classification:

G01N033/567
C07K016/46

US Classification:

435/007210, 530/391100, 530/387300

Abstract:

The present invention provides novel antibody vaccine conjugates and methods of using the same to induce a cytotoxic T cell (CTL) response. In a particular, embodiment, the vaccine conjugate includes a human chorionic gonadotropin beta subunit (hCG) antigen linked to an anti-mannose receptor (MR) antibody.

US Patent:

20050180983, Aug 18, 2005

Filed:

Jul 30, 2004

Appl. No.:

10/903191

Inventors:

Tibor Keler - Ottsville PA, US
Michael Endres - Riegelsville PA, US
Lizhen He - Allentown PA, US
Venky Ramakrishna - Riegelsville PA, US

Assignee:

CELLDEX Therapeutics, Inc. - Bloomsbury NJ

International Classification:

A61K039/395
C07K016/46

US Classification:

424178100, 530391100, 530387300, 530351000

Abstract:

The present invention provides novel antibody vaccine conjugates and methods of using the same to induce a cytotoxic T cell (CTL) response. In a particular, embodiment, the vaccine conjugate includes a human chorionic gonadotropin beta subunit (βhCG) antigen linked to an anti-mannose receptor (MR) antibody.

US Patent:

20090324622, Dec 31, 2009

Filed:

Jul 2, 2009

Appl. No.:

12/496719

Inventors:

Tibor KELER - Ottsville PA, US
Michael ENDRES - Painesville OH, US
Lizhen HE - Allentown PA, US
Venky RAMAKRISHNA - Riegelsville PA, US

International Classification:

A61K 39/44
A61P 35/00

US Classification:

4241821

Abstract:

The present invention provides novel antibody vaccine conjugates and methods of using the same to induce a cytotoxic T cell (CTL) response. In a particular, embodiment, the vaccine conjugate includes a human chorionic gonadotropin beta subunit (βhCG) antigen linked to an anti-mannose receptor (MR) antibody.

US Patent:

20120148596, Jun 14, 2012

Filed:

Feb 15, 2012

Appl. No.:

13/397476

Inventors:

Yashwant M. DEO - East Brunswick NJ, US
Tibor KELER - Ottsville PA, US
John TREML - Philadelphia PA, US
Michael ENDRES - Painesville OH, US

Assignee:

CELLDEX RESEARCH CORPORATION - Phillipsburg NJ

International Classification:

A61K 39/395
C07K 16/00

US Classification:

4241411, 5303881, 5303917

Abstract:

Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to dendritic cells are disclosed. Also disclosed are bispecifics, immunotoxins and antigen conjugates which include the antibodies or antibody portions. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.