Michael W Endres

US Patent:

7763258, Jul 27, 2010

Filed:

Dec 21, 2001

Appl. No.:

10/032311

Inventors:

Robert Doms - Berwyn PA, US
Joseph Rucker - Philadelphia PA, US
Trevor L. Hoffman - Irvine CA, US
Paul Bates - Swarthmore PA, US
James Hoxie - Berwyn PA, US
Michael Endres - Painesville OH, US
John Balliet - Norristown PA, US
Dennis Kolson - Secane PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

A61K 39/12
A61K 39/205

US Classification:

4241991, 4242071, 4242081, 4242241

Abstract:

Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.

US Patent:

8158130, Apr 17, 2012

Filed:

Mar 9, 2010

Appl. No.:

12/720398

Inventors:

Robert W Doms - Berwyn PA, US
Joseph Rucker - Philadelphia PA, US
Trevor L Hoffman - Irvine CA, US
Paul Bates - Swarthmore PA, US
James A Hoxie - Berwyn PA, US
Michael J Endres - Painesville OH, US
John Balliet - Norristown PA, US
Dennis L Kolson - Secane PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia

International Classification:

A61K 39/12
C12P 21/06
C12N 15/00

US Classification:

4241991, 435 691, 4353201

Abstract:

Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.

US Patent:

20120195882, Aug 2, 2012

Filed:

Mar 15, 2012

Appl. No.:

13/421559

Inventors:

Robert Doms - Berwyn PA, US
Joseph Rucker - Philadelphia PA, US
Trevor L. Hoffman - Irvine CA, US
Paul Bates - Swarthmore PA, US
James Hoxie - Berwyn PA, US
Michael Endres - Painesville OH, US
John Balliet - Norristown PA, US
Dennis Kolson - Secane PA, US

International Classification:

A61K 39/12
A61P 37/04
C12N 7/00
A61K 39/395

US Classification:

4241301, 4241991, 4352351

Abstract:

Enveloped virus vectors are described which comprise a cellular virus receptor protein and which are capable of fusing with a cell which comprises a viral envelope protein to which the cellular virus receptor protein is cognate. Enveloped virus vectors comprising a plurality of cellular virus receptor proteins are also described. Methods for making the enveloped virus vectors are described, as are methods of using the enveloped virus vectors. The invention further relates to a lipoparticle comprising a membrane spanning protein, and the lipoparticle can be attached to a sensor surface. The invention relates to methods of producing and using the lipoparticle to, inter alia, assess protein binding interactions.