Michael T Flavin

US Patent:

6399654, Jun 4, 2002

Filed:

Apr 15, 1998

Appl. No.:

09/060839

Inventors:

Yuh-Meei Lin - Naperville IL
David E. Zembower - La Grange Park IL
Michael T. Flavin - Darien IL
Ralph Schure - Darien IL

Assignee:

Advanced Life Sciences, Inc. - Lemont IL

International Classification:

A61K 3135

US Classification:

514456, 514 50, 514261, 514332

Abstract:

Substantially purified antiviral biflavanoids robustaflavone, hinokiflavone, amentoflavone, agathisflavone, volkensiflavone, morelloflavone, rhusflavanone, succedaneaflavanone, GB-1a, and GB-2a are provided. Antiviral biflavanoid derivatives and salt forms thereof, e. g. , robustaflavone tetrasulfate potassium salt, and methods for preparing the same are also disclosed. Pharmaceutical compositions which include the antiviral biflavanoids, derivatives or salts thereof are also provided alone or in combination with at least one antiviral agent such as 3TC. Also disclosed is an improved method for obtaining substantially pure robustaflavone from plant material. The biflavanoid compounds, derivatives or salts thereof of the invention may be used in a method for treating and/or preventing viral infections caused by viral agents such as influenza, e. g. , influenza A and B; hepatitis, e. g. , hepatitis B; human immunodeficiency virus, e. g.

US Patent:

6670383, Dec 30, 2003

Filed:

Mar 15, 2002

Appl. No.:

10/099726

Inventors:

Ze-Qi Xu - Woodridge IL
Krzysztof Pupek - Downers Grove IL
Livia Enache - Plainfield IL
Michael T. Flavin - Darien IL

Assignee:

Advanced Life Sciences, Inc. - Woodridge IL

International Classification:

A61K 3135

US Classification:

514355, 514453, 514454, 514457, 549277, 549282, 549289

Abstract:

The present invention relates to compounds and compositions useful in treating or preventing conditions and diseases related to Mycobacterium infection, and methods of use directed thereto.

US Patent:

7122526, Oct 17, 2006

Filed:

Jun 30, 2003

Appl. No.:

10/610290

Inventors:

Ze-Qi Xu - Woodridge IL, US
Yasheen Zhou - Moraga CA, US
Michael T. Flavin - Darien IL, US

Assignee:

Nanosphere, Inc. - Northbrook IL

International Classification:

A01N 43/04
A61K 31/70
C07G 3/00
C07G 11/00
C07H 15/00
C07H 17/00

US Classification:

514 43, 514 25, 536 174, 536 177, 536 187

Abstract:

The present invention relates to anti-tumor compounds, compositions and methods. In particular, the invention relates to indolocarbazole analogues of the following general formulas that inhibit topoisomerase I activity.

US Patent:

20010021902, Sep 13, 2001

Filed:

Dec 14, 2000

Appl. No.:

09/737204

Inventors:

Michael Flavin - Darien IL, US
Lisa Seaney - Glen Ellyn IL, US

International Classification:

G06G007/48

US Classification:

703/012000

Abstract:

A method and workstation for optimizing chemical processes based on combinatorial chemistry, automation technology, and computer-controlled design is disclosed. The workstation includes a synthesizer, an analyzer, a robot and computer in communication with the synthesizer and analyzer. The computer includes one or more programs for regulating reaction parameters such as temperature, pressure, concentration of reagents and employs statistical methods for optimizing multiple reaction parameters and for designing optimized experiments for further investigation.

US Patent:

20010027209, Oct 4, 2001

Filed:

Dec 11, 2000

Appl. No.:

09/735067

Inventors:

Ze-Qi Xu - Naperville IL, US
Yuh Lin - Naperville IL, US
Michael Flavin - Darien IL, US

Assignee:

Sarawak Medichem Pharmaceuticals, Inc.

International Classification:

A61K031/366
A61K031/655

US Classification:

514/453000, 514/151000

Abstract:

Calanolides and analogues thereof that demonstrate potent mycobacterium activity are provided. Also provided is a method of using calanolides and analogues thereof for treating or preventing mycobacterium infections. The calanolides and analogues thereof provided are obtained via syntheses employing chromene 4 and chromanone 7 as key intermediates.

US Patent:

20020013478, Jan 31, 2002

Filed:

Mar 21, 2001

Appl. No.:

09/814074

Inventors:

Ze-Qi Xu - Naperville IL, US
Michael Flavin - Darien IL, US
David Zembower - Oak Park IL, US

Assignee:

Sarawak Medichem Pharmaceuticals,Inc.

International Classification:

C07D311/78

US Classification:

549/277000

Abstract:

Calanolide analogues that demonstrate potent antiviral activity against many viruses are provided. Also provided is a method of using calanolide analogues for treating or preventing viral infections. The calanolide analogues provided are obtained via syntheses employing chromene 4 and chromanone 7 as key intermediates.

US Patent:

20020068757, Jun 6, 2002

Filed:

Jan 17, 2001

Appl. No.:

09/761909

Inventors:

Yuh-Meei Lin - Naperville IL, US
David Zembower - La Grange Park IL, US
Michael Flavin - Darien IL, US
Ralph Schure - Darien IL, US

Assignee:

Advanced Life Sciences, Inc.

International Classification:

A61K031/7048
A61K031/44
A61K031/352

US Classification:

514/340000, 514/027000, 514/456000

Abstract:

Substantially purified antiviral biflavanoids robustaflavone, hinokiflavone, amentoflavone, agathisflavone, volkensiflavone, morelloflavone, rhusflavanone, succedaneaflavanone, GB-1a, and GB-2a are provided. Antiviral biflavanoid derivatives and salt forms thereof, e.g., robustaflavone tetrasulfate potassium salt, and methods for preparing the same are also disclosed. Pharmaceutical compositions which include the antiviral biflavanoids, derivatives or salts thereof are also provided alone or in combination with at least one antiviral agent such as 3TC. Also disclosed is an improved method for obtaining substantially pure robustaflavone from plant material. The biflavanoid compounds, derivatives or salts thereof of the invention may be used in a method for treating and/or preventing viral infections caused by viral agents such as influenza, e.g., influenza A and B; hepatitis, e.g., hepatitis B; human immunodeficiency virus, e.g., HIV-1; Herpes viruses (HSV-1 and HSV-2); Varicella Zoster virus (VZV); and measles. For instance, semi-synthetic hexa-O-acetate and hexa-O-methyl ether derivatives of robustaflavone have been found to be effective in a method for treating or preventing hepatitis B viral infections. Compositions which include these robustaflavone derivatives along with methods for preparing and using the same are also provided. These compositions may be used alone or in combination with at least one antiviral agent such as 3TC.

US Patent:

20020120432, Aug 29, 2002

Filed:

Aug 10, 2001

Appl. No.:

09/927214

Inventors:

David Ager - Hoffman Estates IL, US
John Aikens - La Grange Park IL, US
Michael Flavin - Darien IL, US
Eric Kirchhoff - Winfield IL, US

International Classification:

G06G007/48

US Classification:

703/012000

Abstract:

A method and workstation for optimizing optimization of biocatalyst performance based on combinatorial chemistry, automation technology, and computer-controlled design is disclosed. The workstation includes a synthesizer, an analyzer, a robot and computer in communication with the synthesizer and analyzer. The computer includes one or more programs for regulating reaction parameters such as types of enzymes; amounts of enzymes; types of solvents/buffers; amounts of solvents/buffers; temperature; pressure; pH; types of substrates; time; enzyme—substrate ratio; and agitation (whether to agitate and the speed of agitation) and employs statistical methods for optimizing multiple reaction parameters and for designing optimized experiments for further investigation.