Michael A Flavin

US Patent:

6670383, Dec 30, 2003

Filed:

Mar 15, 2002

Appl. No.:

10/099726

Inventors:

Ze-Qi Xu - Woodridge IL
Krzysztof Pupek - Downers Grove IL
Livia Enache - Plainfield IL
Michael T. Flavin - Darien IL

Assignee:

Advanced Life Sciences, Inc. - Woodridge IL

International Classification:

A61K 3135

US Classification:

514355, 514453, 514454, 514457, 549277, 549282, 549289

Abstract:

The present invention relates to compounds and compositions useful in treating or preventing conditions and diseases related to Mycobacterium infection, and methods of use directed thereto.

US Patent:

7122526, Oct 17, 2006

Filed:

Jun 30, 2003

Appl. No.:

10/610290

Inventors:

Ze-Qi Xu - Woodridge IL, US
Yasheen Zhou - Moraga CA, US
Michael T. Flavin - Darien IL, US

Assignee:

Nanosphere, Inc. - Northbrook IL

International Classification:

A01N 43/04
A61K 31/70
C07G 3/00
C07G 11/00
C07H 15/00
C07H 17/00

US Classification:

514 43, 514 25, 536 174, 536 177, 536 187

Abstract:

The present invention relates to anti-tumor compounds, compositions and methods. In particular, the invention relates to indolocarbazole analogues of the following general formulas that inhibit topoisomerase I activity.

US Patent:

20010021902, Sep 13, 2001

Filed:

Dec 14, 2000

Appl. No.:

09/737204

Inventors:

Michael Flavin - Darien IL, US
Lisa Seaney - Glen Ellyn IL, US

International Classification:

G06G007/48

US Classification:

703/012000

Abstract:

A method and workstation for optimizing chemical processes based on combinatorial chemistry, automation technology, and computer-controlled design is disclosed. The workstation includes a synthesizer, an analyzer, a robot and computer in communication with the synthesizer and analyzer. The computer includes one or more programs for regulating reaction parameters such as temperature, pressure, concentration of reagents and employs statistical methods for optimizing multiple reaction parameters and for designing optimized experiments for further investigation.

US Patent:

20030004653, Jan 2, 2003

Filed:

Mar 1, 2002

Appl. No.:

10/087102

Inventors:

Michael Flavin - Darien IL, US
Sreenivasarao Vepachedu - Palo Alto CA, US
David Zembower - LaGrange IL, US

International Classification:

G06G007/48
G06G007/58
G06F019/00
G01N031/00

US Classification:

702/022000, 562/402000, 703/012000

Abstract:

A method and workstation for optimizing separation of a given racemate automation technology, and computer-controlled design is disclosed. The workstation includes a synthesizer, an analyzer, a robot and computer in communication with the synthesizer and analyzer. The computer includes one or more programs for regulating variables such as types of stationary phases; types of solvents; amounts of solvents; pressure; temperature; and employs methods for optimizing separation of a given racemate and for designing optimized experiments for further investigation.

US Patent:

20070232577, Oct 4, 2007

Filed:

Mar 23, 2007

Appl. No.:

11/728284

Inventors:

Ze-Qi Xu - Woodridge IL, US
Ali Koohang - Plainfield IL, US
Aye Aye Mar - Tinley Park IL, US
Nathan Majewski - Bryn Mawr PA, US
David Eiznhamer - Bloomingdale IL, US
Michael Flavin - Darien IL, US

Assignee:

Advanced Life Sciences, Inc. - Woodridge IL

International Classification:

A61K 31/58
A61K 31/56
C07J 53/00

US Classification:

514169000, 514176000, 540047000, 552511000

Abstract:

The present invention comprises small molecule inhibitors of cell proliferative conditions, in particular cancer and conditions associated with cancer. For example, associated malignancies include ovarian cancer, cervical cancer, breast cancer, colorectal cancer, and glioblastomas, among others. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting these diseases. Thus, the present invention also comprising pharmaceutical formulations comprising the compounds and methods of using the compounds and formulations to inhibit cancer and treat, prevent, or inhibit the foregoing diseases.

US Patent:

62254812, May 1, 2001

Filed:

Aug 21, 1998

Appl. No.:

9/137767

Inventors:

David E. Zembower - La Grange IL
Heping Zhang - Elmhurst IL
Michael T. Flavin - Darien IL
Yuh-Meei Lin - Naperville IL

Assignee:

Advanced Life Sciences, Inc. - Lemont IL

International Classification:

C07D31176

US Classification:

549402

Abstract:

Robustaflavone, intermediates and analogues thereof and a method for synthesizing the same are provided. The method involves constructing apigenin ethers containing functionalities at the 6- and 3'-positions which could be cross-coupled using transition metal catalysis. The method also involves development of a regioselective iodination of an apigenin derivative at the 6-position, formation of an apigenin 3'-boronate using a palladium-catalyzed exchange of the corresponding 3'-iodide with a diboron reagent. Finally, Suzuki coupling to form the sterically congested 6-3'" biaryl bond of robustaflavone provides access to the desired biflavanoid system. Robustaflavone intermediates and analogues may be used to prepare analogues of other biflavanoids such as hinokifavone, rhusflavone and succedaneaflavone.

US Patent:

59773855, Nov 2, 1999

Filed:

Jul 15, 1998

Appl. No.:

9/115984

Inventors:

Michael T. Flavin - Darien IL
Ze-Qi Xu - Naperville IL
Albert Khilevich - Glenview IL
David Zembower - Oak Park IL
John D. Rizzo - Downers Grove IL
Shuyuan Liao - Glen Ellyn IL
Aye Mar - Chicago IL
Lin Lin - Chicago IL
Vilayphone Vilaychack - Elgin IL
Darko Brankovic - Bolingbrook IL
Sergey Dzekhster - Chicago IL
Jinjun Liu - Naperville IL

Assignee:

Sarawak MediChem Pharmaceuticals - Lemont IL

International Classification:

C07D49300

US Classification:

549282

Abstract:

A method of preparing (+)-calanolide A, 1, a potent HIV reverse transcriptase inhibitor, from chromene 4 is provided. According to the disclosed method, chromene 4 intermediate was subjected to a chlorotitanium-mediated aldol reaction with acetaldehyde to selectively produce (. +-. )-8a. Separation and enzyme-mediated resolution of (. +-. )-8a produced (+)-8a. Cyclization of (+)-8a under neutral Mitsunobu conditions followed by Luche reduction of (+)-7 produced (+)-calanolide A in high yield and enantiomeric purity. The method of the invention has been extended to produce potent antiviral calanolide A analogues.

US Patent:

58521984, Dec 22, 1998

Filed:

Apr 2, 1997

Appl. No.:

8/831233

Inventors:

Yibo Xu - Chicago IL
Michael T. Flavin - Darien IL

Assignee:

Medichem Research, Inc. - Lemont IL

International Classification:

C07F 954

US Classification:

558 87

Abstract:

Wittig-type reagents and methods of preparation and use thereof for preparing. alpha. ,. beta. -unsaturated phosphonate esters from aldehydes and ketones are disclosed. The Wittig-type reagents have the following formulae: ##STR1## wherein X represents triflate, halide, BF. sub. 4, SbF. sub. 6, or ClO. sub. 4 ; R. sub. 1 represents alkyl, aryl or arylalkyl; and R. sub. 2 represents alkyl, aryl or arylalkyl, provided that R. sub. 1 and R. sub. 2 not represent phenyl at the same time. The Wittig reagent diethyl phosphono-methylidenetriphenylphosphorane (1b) has been successfully synthesized for the first time via its phosphonium triflate salt (4a), by treating diethyl phosphonomethyltriflate with triphenylphosphine according to the disclosed method. The procedure has been applied to the synthesis of other new Wittig-type reagents such as phosphoranes and phosphonium salts. The new Wittig reagents thus synthesized were treated with various aldehydes and an activated ketone, affording the corresponding. alpha. ,. beta.