Michael J Frank

US Patent:

7049282, May 23, 2006

Filed:

Oct 26, 2001

Appl. No.:

09/984017

Inventors:

Michael M. Frank - Durham NC, US
Haixiang J. Jiang - Chapel Hill NC, US

Assignee:

Duke University - Durham NC

International Classification:

A01N 37/18

US Classification:

514 2, 514 21, 514 14, 514 15

Abstract:

The present invention relates to a method of blocking biochemical function of the classical complement pathway and thereby preventing immunologic damage in a variety of diseases and conditions including autoimmune diseases.

US Patent:

7208120, Apr 24, 2007

Filed:

Sep 27, 2001

Appl. No.:

09/965644

Inventors:

Mark W. Bitensky - Waban MA, US
Tatsuro Yoshida - Newton MA, US
Michael G. Frank - East Lansing MI, US
Christopher V Gabel - Sumerville MA, US
Jure Derganc - Ljubljana, SI

Assignee:

The Trustees of Boston University - Boston MA

International Classification:

G01N 15/06
G01N 33/00
G01N 33/48
C12M 1/34
C12M 3/00

US Classification:

422 681, 422 73, 4352871, 4352884, 4352885

Abstract:

A cellular diagnostic array has been developed that provides accurate and reproducible measurements of the physical parameters of individual cells en masse, including cell membrane surface area, cell volume, and excess membrane. Three differing patterns are employed. In the first design, a gradient array having rectangular shaped channels is used to capture cells and readily show the ratio of volume to surface area for the captured cell. The second silicone rubber array provided by the present invention employs an array of wedge shaped pipettes, each of which captures an individual cell. The position of the cell within a wedge is enough to rapidly determine the cell's actual surface area and volume. A third type of cellular diagnostic array according to the present invention employs an array of channels designed to deform a cell to study how well the cell responds to repeated deformations.

US Patent:

D598674, Aug 25, 2009

Filed:

Sep 15, 2008

Appl. No.:

29/324532

Inventors:

Michael G. Frank - Boston MA, US

International Classification:

0604

US Classification:

D 6479

US Patent:

20050060687, Mar 17, 2005

Filed:

Sep 15, 2003

Appl. No.:

10/663455

Inventors:

David Ghazaleh - Apex NC, US
Michael Frank - Raleigh NC, US
James Shivers - Efland NC, US
John Griffin - Durham NC, US

International Classification:

G06F009/44

US Classification:

717123000

Abstract:

The invention is a method and apparatus for defining, representing, and/or documenting object oriented programming applications, and particularly, those developed to work in a graphical user interface. The invention represents the applications in one or more diagrams termed Object and Event Diagrams (OEDs). The invention allows an application architect to communicate the program idea to the programmer by defining the program basis and the program logic without concern about details of the user interface such as how actions will be executed (which will be determined by the programmer). The OED may be used as a program specification, a program requirements description or as a documentation tool to document the logic of the object and event used in a program. The application architect represents the program in an OED using a plurality of different types of symbols that represent different types of objects and other program elements, such as data transfer, inheritance and remote links. The various symbols are interconnected by lines that show their relationships to each other.

US Patent:

20070110685, May 17, 2007

Filed:

Jun 16, 2006

Appl. No.:

11/454202

Inventors:

Benjamin Auspitz - Cambridge MA, US
Bradley Brasher - Natick MA, US
Todd Chappell - Boston MA, US
Michael Frank - Boston MA, US
Daniel Grau - Arlington MA, US
Seth Lederman - New York NY, US
Palaniyandi Manivasakam - West Roxbury MA, US
Seth Orlow - New York NY, US
Noah Sachs - South Boston MA, US
Brendan Smith - Somerville MA, US

International Classification:

A61K 8/49
A61K 38/13
A61K 31/4745
A61K 31/385
A61K 31/522
A61K 31/4178

US Classification:

424059000, 514011000, 514183000, 514263320, 514291000, 514397000, 514471000, 424641000

Abstract:

The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering a non-steroidal immunophilin-dependent immunosuppressant (NsIDI) and a Group A enhancer (e.g., antifungal agent, antigout agent, anti-infective agent, antiprotozoal agent, antiviral agent, humectant, sunscreen, vitamin D compound, microtubuline inhibitor, or zinc salt) or analog or metabolite thereof to the patient. The invention also features a pharmaceutical composition containing an NsIDI and Group A enhancer or analog or metabolite thereof for the treatment or prevention of an immunoinflammatory disorder.

US Patent:

20080161324, Jul 3, 2008

Filed:

Sep 13, 2007

Appl. No.:

11/900893

Inventors:

Lisa M. Johansen - Belmont MA, US
Christopher M. Owens - Cambridge MA, US
Christina Mawhinney - Jamaica Plain MA, US
Todd W. Chappell - Boston MA, US
Alexander T. Brown - Watertown MA, US
Michael G. Frank - Boston MA, US
Ralf Altmeyer - Singapore, SG

International Classification:

A61K 31/495
A61K 31/135
C12Q 1/68
A61K 31/404
A61K 31/351
A61K 31/4965
A61K 31/21
A61P 31/20

US Classification:

51425503, 514647, 435 6, 514415, 514460, 514275, 514529

Abstract:

The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E). Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.

US Patent:

20100009970, Jan 14, 2010

Filed:

Mar 18, 2009

Appl. No.:

12/406626

Inventors:

Lisa M. Johansen - Belmont MA, US
Christopher M. Owens - Cambridge MA, US
Christina Mawhinney - Jamaica Plain MA, US
Todd W. Chappell - Boston MA, US
Alexander T. Brown - Watertown MA, US
Michael G. Frank - Boston MA, US
Michael A. Foley - Chestnut hill MA, US
Ralf Altmeyer - Singapore, SG
Yu Chen - Singapore, SG

Assignee:

Combinatorx (Singapore) Pte. Ltd. - Singapore

International Classification:

A61K 31/136
A61K 31/404
A61K 31/366
A61K 31/505
A61K 31/495
C07C 211/33
C07C 217/56
A61P 25/00
A61K 31/445
A61K 31/551
A61K 31/5375
A61K 31/4965

US Classification:

514218, 514647, 514419, 514460, 514275, 51425504, 564367, 514603, 514655, 564384, 514331, 5142395, 51425503

Abstract:

The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E) and the agent or combination of agents includes sertraline, a sertraline analog, UK-416244, or a UK-416244 analog. Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.