John D. DiMarco - East Brunswick NJ, US Jack Z. Gougoutas - Princeton NJ, US Imre M. Vitez - Whitehouse Station NJ, US Martha Davidovich - East Brunswick NJ, US Michael A. Galella - Old Bridge NJ, US Timothy M. Malloy - Yardley PA, US Zhenrong Guo - East Brunswick NJ, US Denis Favreau - Saint-Hubert, CA
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D 493/04 A61K 31/42
US Classification:
514365, 540456, 540462
Abstract:
There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula Also provided are methods of forming the novel polymorphs, therapeutic methods utilizing them and pharmaceutical dosage forms containing them.
John D. DiMarco - East Brunswick NJ, US Jack Z. Gougoutas - Princeton NJ, US Imre M. Vitez - Whitehouse Station NJ, US Martha Davidovich - East Brunswick NJ, US Michael A. Galella - Old Bridge NJ, US Timothy M. Malloy - Yardley PA, US Zhenrong Guo - East Brunswick NJ, US Denis Favreau - Saint-Hubert, CA
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D 493/04 A61K 31/42 A61P 35/00
US Classification:
514365, 540456, 540462
Abstract:
There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula.
Process For Preparing 2-Aminothiazole-5-Aromatic Carboxamides As Kinase Inhibitors
Jean Lajeunesse - Candiac, CA John D. DiMarco - East Brunswick NJ, US Michael Galella - Kendall Park NJ, US Ramakrishnan Chidambaram - Pennington NJ, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A61K 31/506 C07D 403/04
US Classification:
51425219, 544295
Abstract:
The invention relates to processes for preparing compounds having the formula,.
Triazolopyridine 11-Beta Hydroxysteroid Dehydrogenase Type I Inhibitors
Jun Li - Princeton NJ, US Jeffrey A. Robl - Newtown PA, US James J. Li - Pennington NJ, US Lawrence J. Kennedy - Titusville NJ, US Haixia Wang - Princeton NJ, US Jie Jack Li - Killingworth CT, US Xinhua Qian - Flemington NJ, US Rajendra P. Deshpande - Hillsborough NJ, US Laxma R. Kolla - Princeton Junction NJ, US Reginald O. Cann - Princeton Junction NJ, US Chenkou Wei - Princeton Junction NJ, US Michael Galella - Kendall Park NJ, US
Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds of formula I:.
Process For Preparing 2-Aminothiazole-5-Aromatic Carboxamides As Kinase Inhibitors
Jean Lajeunesse - Candiac, CA John D. DiMarco - East Brunswick NJ, US Michael Galella - Kendall Park NJ, US Ramakrishnan Chidambaram - Santa Clara CA, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D 403/04
US Classification:
544295
Abstract:
The invention relates to processes for preparing compounds having the formula,.
Triazolopyridine 11-Beta Hydroxysteroid Dehydrogenase Type I Inhibitors
Jun Li - Princeton NJ, US Jeffrey A. Robl - Newtown PA, US James J. Li - Pennington NJ, US Lawrence J. Kennedy - Titusville NJ, US Haixia Wang - Princeton NJ, US Jie Jack Li - Killingworth CT, US Chenkou Wei - Princeton Junction NJ, US Michael Galella - Kendall Park NJ, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D 471/02 C07D 491/02 C07D 498/02 A61K 31/44
US Classification:
514303, 546119
Abstract:
Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds of formula I:.
John DiMarco - East Brunswick NJ, US Jack Gougoutas - Princeton NJ, US Imre Vitez - Whitehouse Station NJ, US Martha Davidovich - East Brunswick NJ, US Michael Galella - Old Bridge NJ, US Timothy Malloy - Yardley PA, US Zhenrong Guo - East Brunswick NJ, US Denis Favreau - Saint-Hubert, CA
International Classification:
C07D491/02 A61K031/427
US Classification:
514/365000, 540/462000
Abstract:
There are provided in accordance with the present invention two crystalline polymorphs, designated Form A and Form B, respectively, as well as mixtures thereof, of an epothilone analog represented by the formula Also provided are methods of forming the novel polymorphs, therapeutic methods utilizing them and pharmaceutical dosage forms containing them.
Process For Preparing 2-Aminothiazole-5-Aromatic Carboxamides As Kinase Inhibitors
Roberto Droghini - Candiac, CA Jean Lajeunesse - Candiac, CA John Dimarco - East Brunswick NJ, US Michael Galella - Kendall Park NJ, US Ramakrishnan Chidambaram - Pennington NJ, US
International Classification:
A61K031/426 C07D417/02
US Classification:
548190000
Abstract:
The invention relates to processes for preparing compounds having the formula, and crystalline forms thereof, wherein Ar is aryl or heteroaryl, L is an optional alkylene linker, and R, R, R, and R, are as defined in the specification herein, which compounds are useful as kinase inhibitors, in particular, inhibitors of protein tyrosine kinase and p38 kinase.