Michael S Gavin

US Patent:

55342264, Jul 9, 1996

Filed:

Apr 19, 1995

Appl. No.:

8/424063

Inventors:

Michael Gavin - Warren NJ
Catherine M. Cimini - Somerset NJ
Ming Huang - Milltown NJ
Anthony Kuklo - Bridgewater NJ
James A. Mawhirt - Brooklyn NY
Eduardo Marcelino - Edison NJ

Assignee:

International Technidyne Corporation - Edison NJ

International Classification:

G01N 3386

US Classification:

422 73

Abstract:

A portable device for performing coagulation tests on a patient's blood. Blood is first drawn from a patient using a lancet. The blood is then supplied to a disposable cuvette placed within the testing device. The blood is drawn into multiple conduits within the cuvette. Each of the conduits contains a dried or lyophilized activation reagent that is rehydrated by the blood. The blood in each of the conduits is then reciprocally moved across a restricted region until a predetermined device of coagulation occurs. Since the coagulation time is being monitored in multiple conduits, a representation coagulation time for a given sample can be determined. In at least one of the conduits a normalizing control agent is present. The normalizing consol agent counteracts any effects of anticoagulants present in the blood sample, thereby allowing the blood sample to have generally normal coagulation characteristics. The normalized blood is tested simultaneously with the untreated blood to provide a reference value against which the functionality of the test system and the quality of the sample can be judged.

US Patent:

55914039, Jan 7, 1997

Filed:

Mar 18, 1996

Appl. No.:

8/617296

Inventors:

Michael Gavin - Warren NJ
Catherine M. Cimini - Somerset NJ
Ming Huang - Milltown NJ
Anthony Kuklo - Bridgewater NJ
James A. Mawhirt - Brooklyn NY
Eduardo Marcelino - Edison NJ
Albert Simone - Fords NJ

Assignee:

International Technidyne Corporation - Edison NJ

International Classification:

G01N 3386

US Classification:

422 73

Abstract:

A portable device for performing coagulation tests on a patient's blood. Blood is first drawn from a patient using a lancet. The blood is then supplied to a disposable cuvette placed within the testing device. The blood is drawn into multiple conduits within the cuvette. Each of the conduits contains a dried or lyophilized activation reagent that is rehydrated by the blood. The blood in each of the conduits is then reciprocally moved across a restricted region until a predetermined degree of coagulation occurs. Since the coagulation time is being monitored in multiple conduits, a representation coagulation time for a given sample can be determined. In at least one of the conduits a normalizing control agent is present. The normalizing control agent counteracts any effects of anticoagulants present in the blood sample, thereby allowing the blood sample to have generally normal coagulation characteristics. The normalized blood is tested simultaneously with the untreated blood to provide a reference value against which the functionality of the test system and the quality of the sample can be judged.

US Patent:

58363602, Nov 17, 1998

Filed:

Mar 25, 1997

Appl. No.:

8/823973

Inventors:

Michael Gavin - Warren NJ
James A. Mawhirt - Brooklyn NY

Assignee:

International Technidyne Corporation - Edison NJ

International Classification:

B65B 104
B65B 304

US Classification:

141126

Abstract:

A volume-control receptacle has a reservoir with a bottom. The reservoir is adapted for receiving a fluid. The receptacle has a plurality of capillaries opening on the reservoir at a specific height above the bottom; the capillaries draw off the excess fluid from the receptacle, thereby leaving a specific amount of fluid in the reservoir. In a preferred embodiment, the volume-control receptacle is adapted for use with a disposable cuvette. The reservoir of the receptacle has a drain at the bottom connected to the cuvette for delivering the fluid to a testing instrument or other final application point. The volume-control receptacle has a lip projecting upward from a promontory of the receptacle. A rib extends downward from the lip to the bottom of the reservoir for guiding the fluid into the reservoir.

US Patent:

57312125, Mar 24, 1998

Filed:

Dec 20, 1994

Appl. No.:

8/359923

Inventors:

Michael Gavin - Warren NJ
James A. Mawhirt - Brooklyn NY
Donald W. Allen - Point Pleasant NJ

Assignee:

International Technidyne Corporation - Edison NJ

International Classification:

G01N 33553
G01N 33558

US Classification:

436526

Abstract:

A cuvette based testing device for use in testing or otherwise analyzing a fluid sample. A cuvette is provided that defines at least one conduit, wherein the fluid sample is introduced into the various conduits. Reagents are disposed within the conduits that are intended to be mixed with the fluid sample. The fluid sample is drawn into the conduits by the force of a pneumatic pump. As the fluid sample contacts the various reagents, the reagents mix with the sample. Mixing is further conducted by moving the fluid sample back and forth across an obstruction in the conduit. The obstruction causes turbulent flow in the fluid sample, thereby mixing the sample with any reagent also present. The conduit is preferably transparent. The fluid sample is brought to a point in the cuvette where it is disposed below a detector.

US Patent:

58007814, Sep 1, 1998

Filed:

Sep 25, 1996

Appl. No.:

8/719779

Inventors:

Michael Gavin - Warren NJ
Catherine M. Cimini - Somerset NJ
Ming Huang - Milltown NJ
Anthony Kuklo - Bridgewater NJ
James A. Mawhirt - Brooklyn NY
Eduardo Marcelino - Edison NJ
Albert Simone - Fords NJ

Assignee:

International Technidyne Corporation - Edison NJ

International Classification:

G01N 3386

US Classification:

422 73

Abstract:

A portable device for performing coagulation tests on a patient's blood. Blood is first drawn from a patient using a lancet. The blood is then supplied to a disposable cuvette placed within the testing device. The blood is drawn into multiple conduits within the cuvette. Each of the conduits contains a dried or lyophilized activation reagent that is rehydrated by the blood. The blood in each of the conduits is then reciprocally moved across a restricted region until a predetermined degree of coagulation occurs. Since the coagulation time is being monitored in multiple conduits, a representation coagulation time for a given sample can be determined. In at least one of the conduits a normalizing control agent is present. The normalizing control agent counteracts any effects of anticoagulants present in the blood sample, thereby allowing the blood sample to have generally normal coagulation characteristics. The normalized blood is tested simultaneously with the untreated blood to provide a reference value against which the functionality of the test system and the quality of the sample can be judged.

US Patent:

55040110, Apr 2, 1996

Filed:

Oct 21, 1994

Appl. No.:

8/327320

Inventors:

Michael Gavin - Warren NJ
Catherine M. Cimini - Somerset NJ
Ming Huang - Milltown NJ
Anthony Kuklo - Bridgewater NJ
James A. Mawhirt - Brooklyn NY
Eduardo Marcelino - Edison NJ
Albert Simone - Fords NJ

Assignee:

International Technidyne Corporation - Edison NY

International Classification:

G01N 3386

US Classification:

436 69

Abstract:

A portable device for performing coagulation tests on a patient's blood. Blood is first drawn from a patient using a lancet. The blood is then supplied to a disposable cuvette placed within the testing device. The blood is drawn into multiple conduits within the cuvette. Each of the conduits contains a dried or lyophilized activation reagent that is rehydrated by the blood. The blood in each of the conduits is then reciprocally moved across a restricted region until a predetermined degree of coagulation occurs. Since the coagulation time is being monitored in multiple conduits, a representation coagulation time for a given sample can be determined. In at least one of the conduits a normalizing control agent is present. The normalizing control agent counteracts any effects of anticoagulants present in the blood sample, thereby allowing the blood sample to have generally normal coagulation characteristics. The normalized blood is tested simultaneously with the untreated blood to provide a reference value against which the functionality of the test system and the quality of the sample can be judged.