Michael F Girgis

US Patent:

6740776, May 25, 2004

Filed:

Jul 15, 2002

Appl. No.:

10/196600

Inventors:

Ratna Shekhar - Madison NJ
Michael John Girgis - Montville NJ

Assignee:

Novartis AG - Basel

International Classification:

C07C 5123

US Classification:

562418, 562421

Abstract:

A low temperature process for preparing an aromatic acid having formula (I), said process comprising reacting an aromatic aldehyde having formula (II) with a gas having an oxygen content of 1 to 100 weight percent, based on the total weight of the gas, at a temperature of about 20Â C. to less than 100Â C. in the presence of a supported Group VIII metal catalyst, and a solvent having a flash point greater than 95Â C. and/or a melting point less than 55Â C. , provided that the flash point of the solvent is greater than the reaction temperature, wherein R and R are independently selected from the group consisting of hydrogen and a C -C linear, branched or cyclic alkyl group. The process of the invention yields an aromatic acid in excellent yield, and (i) does not involve the use of deleterious oxidizing agents; (ii) is essentially free of by-products; and (iii) is accomplished at a temperature of less than 100Â C.

US Patent:

20080221336, Sep 11, 2008

Filed:

Jul 12, 2006

Appl. No.:

11/995261

Inventors:

Christine E. Garrett - Bridgewater NJ, US
Guang-Pei Chen - Livingston NJ, US
George Tien-San Lee - Towaco NJ, US
Xinglong Jiang - Hillsborough NJ, US
Michael J. Girgis - Montville NJ, US
James Anthony Vivelo - Basking Ridge NJ, US
Dimitris Papoutsakis - Acton MA, US
Piotr Karpinski - Lincoln Park NJ, US
Prasad Koteswara Kapa - Parsippany NJ, US
Ada Skorodinsky - Livingston NJ, US

International Classification:

C07D 263/32

US Classification:

548235

Abstract:

This invention provides a method for preparing compounds having the structure [Formula (I)] wherein L is [Formula (A)] or [Formula (B)] in which Ris hydrogen or optionally substituted alkyl, n is zero or 1 and m is 1; wherein R is H, halogen, optionally substituted Calkyl or Calkoxy; wherein Z is a bond, O or S; wherein p is an integer from 1 to 5; wherein Q is a bond provided that Z is not a bond when p is 1; or Q is O, S or —C(O)NR— in which Ris hydrogen, optionally substituted alkyl or cycloalkyl; or Q is —NR—, —NRC(O)NH— or —NRC(O)O— in which Ris hydrogen, alkyl or aralkyl provided that p is not 1; wherein W is cycloalkyl, aryl or heterocyclyl; or W and Rform a 9- to 10-membered bicyclic ring, which may be optionally substituted or may contain oxygen, nitrogen or sulfur.

US Patent:

20130184311, Jul 18, 2013

Filed:

Oct 5, 2011

Appl. No.:

13/876063

Inventors:

Paul Allen Sutton - Parsippany NJ, US
Michael J. Girgis - Montville NJ, US
Jessica Liang - Annandale NJ, US
Mahavir Prashad - Montville NJ, US
Edwin Bernard Villhauer - Morristown NJ, US

Assignee:

NOVARTIS AG - Basel

International Classification:

C07D 213/72
A61K 45/06
A61K 31/444

US Classification:

514332, 546264

Abstract:

The present invention relates to novel crystalline forms of (4-{4-[5-(6-Trifluoromethyl-pyridin-3-ylamino)-pyridin-2-yl]-phenyl}-cyclohexyl)-acetic acid, sodium and their use in the treatment or prevention of a condition or a disorder associated with DGAT1 activity in animals, particularly humans. It also relates to processes for making such novel crystalline forms.

US Patent:

52849856, Feb 8, 1994

Filed:

Oct 5, 1992

Appl. No.:

7/955774

Inventors:

Michael J. Girgis - Lawrenceville NJ
Ying-Yen P. Tsao - Lahaska PA

Assignee:

Mobil Oil Corp. - Fairfax VA

International Classification:

C07C 527

US Classification:

585310

Abstract:

The present invention provides a two-stage process for production of high-octane naphtha range isoparaffins from a feed rich in normal and/or slightly branched paraffins. In the first stage, the normal and/or slightly branched paraffins are selectively converted to multi-branched paraffins and then cracked in a second stage to yield naphtha range isoparaffins which can be blended into a high-octane gasoline pool.

US Patent:

62713949, Aug 7, 2001

Filed:

Nov 2, 2000

Appl. No.:

9/704500

Inventors:

Ratna Shekhar - Madison NJ
Michael John Girgis - Montville NJ

Assignee:

Novartis AG - Basel

International Classification:

C07D20700

US Classification:

548537

Abstract:

Disclosed are methods for the synthesis of amino acid amides which comprise providing a fixed bed of a cation exchange resin, admixing a primary alcohol and an amino acid in a reaction vessel in fluid communication with the fixed bed to form a first mixture, contacting the fixed bed of cation exchange resin with the first mixture for a period of time, thereby causing amino acid ester intermediate to be formed on the cation exchange resin, adding liquid ammonia to the reaction vessel, and contacting the fixed bed of cation exchange resin with ammonia, the fixed bed having previously been contacted with the first mixture.

US Patent:

53649974, Nov 15, 1994

Filed:

Jul 6, 1993

Appl. No.:

8/087955

Inventors:

Michael J. Girgis - Lawrenceville NJ
Ying-Yen P. Tsao - Lahaska PA

Assignee:

Mobil Oil Corporation - Fairfax VA

International Classification:

C07C 527

US Classification:

585253

Abstract:

The present invention relates to a process for upgrading multi-branched C. sub. 9 + olefinic and/or paraffinic by-products of heavy hydrocarbon upgrading processes including alkylation, polymerization, and MOGD, to high octane gasoline. Feeds rich in multi-branched C. sub. 9 + olefins and/or paraffins are contacted with hydrogen at a pressure in the range of about 200 psig to about 2000 psig in the presence of an unsulfided catalyst composition comprising a low acidity molecular sieve having an Alpha Value of 5 or less. Because of the capability of the catalyst to crack at unsubstituted carbon-carbon bonds, the paraffinic products are more highly branched, and thus higher in octane number than those obtained from conventional dual function hydrocracking catalysts having Alpha Values greater than 5.

US Patent:

20220331282, Oct 20, 2022

Filed:

Jun 23, 2022

Appl. No.:

17/847588

Inventors:

- East Hanover NJ, US
Sven Erik GODTFREDSEN - Chatham NJ, US
Paul Allen SUTTON - Getzville NY, US
Mahavir PRASHAD - Montville NJ, US
Michael J. GIRGIS - Montville NJ, US
Bin HU - Green Brook NJ, US
Yugang LIU - Warren NJ, US
Thomas J. BLACKLOCK - East Hanover NJ, US
Piotr Henryk KARPINSKI - Lincoln Park NJ, US

International Classification:

A61K 31/216
A61K 31/41
A61K 45/06
A61K 31/4422
A61K 31/5415
C07C 233/47
C07D 257/04
C07D 207/50

Abstract:

An amorphous solid form of a compound comprising of the angiotensin receptor antagonist (ARB) valsartan, the neutral endopeptidase inhibitor (NEPi) (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methylpentanoic acid ethyl ester and sodium cations is provided. This is compound is useful for the treatment of hypertension and/or heart failure.

US Patent:

20220257551, Aug 18, 2022

Filed:

May 6, 2022

Appl. No.:

17/738565

Inventors:

- East Hanover NJ, US
Sven Erik GODTFREDSEN - Chatham NJ, US
Paul Allen SUTTON - Getzville NY, US
Mahavir PRASHAD - Montville NJ, US
Michael J. GIRGIS - Montville NJ, US
Bin HU - Green Brook NJ, US
Yugang LIU - Warren NJ, US
Thomas J. BLACKLOCK - East Hanover NJ, US
Piotr Henryk KARPINSKI - Lincoln Park NJ, US

International Classification:

A61K 31/216
A61K 31/41
A61K 45/06
A61K 31/4422
A61K 31/5415
C07C 233/47
C07D 257/04
C07D 207/50

Abstract:

An amorphous solid form of a compound comprising of the angiotensin receptor antagonist (ARB) valsartan, the neutral endopeptidase inhibitor (NEPi) (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methylpentanoic acid ethyl ester and sodium cations is provided. This is compound is useful for the treatment of hypertension and/or heart failure.