Michael A Girgis

US Patent:

6740776, May 25, 2004

Filed:

Jul 15, 2002

Appl. No.:

10/196600

Inventors:

Ratna Shekhar - Madison NJ
Michael John Girgis - Montville NJ

Assignee:

Novartis AG - Basel

International Classification:

C07C 5123

US Classification:

562418, 562421

Abstract:

A low temperature process for preparing an aromatic acid having formula (I), said process comprising reacting an aromatic aldehyde having formula (II) with a gas having an oxygen content of 1 to 100 weight percent, based on the total weight of the gas, at a temperature of about 20Â C. to less than 100Â C. in the presence of a supported Group VIII metal catalyst, and a solvent having a flash point greater than 95Â C. and/or a melting point less than 55Â C. , provided that the flash point of the solvent is greater than the reaction temperature, wherein R and R are independently selected from the group consisting of hydrogen and a C -C linear, branched or cyclic alkyl group. The process of the invention yields an aromatic acid in excellent yield, and (i) does not involve the use of deleterious oxidizing agents; (ii) is essentially free of by-products; and (iii) is accomplished at a temperature of less than 100Â C.

US Patent:

6835838, Dec 28, 2004

Filed:

Jan 24, 2003

Appl. No.:

10/350615

Inventors:

Guang-Pei Chen - Livingston NJ
Prasad Koteswara Kapa - Parsippany NJ
Eric M. Loeser - Lake Hiawatha NJ
Ulrich Beutler - Oberwil, CH
Werner Zaugg - Riehen, CH
Michael John Girgis - Montville NJ

Assignee:

Novartis AG - Basel

International Classification:

C07D21554

US Classification:

546173

Abstract:

A method for preparing an alkali metal salt comprising: (a) condensing a disilyloxydiene with an aldehyde in the presence of a titanium (IV) catalyst in an inert solvent to form a 5(S)-hydroxy-3-ketoester; (b) reducing the 5(S)-hydroxy-3-ketoester to a 3(R),5(S)-dihydroxyester in the presence of a di(lower alkyl)methoxyborane; and (c) hydrolyzing the 3(R),5(S)-dihydroxyester in the presence of an aqueous base to form an alkali metal salt.

US Patent:

7572917, Aug 11, 2009

Filed:

Jul 14, 2004

Appl. No.:

10/891357

Inventors:

Guang-Pei Chen - Livingston NJ, US
Prasad K Kapa - Parsippany NJ, US
Eric M Loeser - Lake Hiawatha NJ, US
Ulrich Beutler - Oberwil, CH
Werner Zaugg - Riehen, CH
Michael J Girgis - Montville NJ, US

Assignee:

Novartis AG - Basel

International Classification:

C07D 215/12

US Classification:

546173, 546174

Abstract:

A method for preparing an alkali metal salt comprising: (a) condensing a disilyloxydiene with an aldehyde in the presence of a titanium (IV) catalyst in an inert solvent to form a 5(S)-hydroxy-3-ketoester; (b) reducing the 5(S)-hydroxy-3-ketoester to a 3(R),5(S)-dihydroxyester in the presence of a di(lower alkyl)methoxyborane; and (c) hydrolyzing the 3(R),5(S)-dihydroxyester in the presence of an aqueous base to form an alkali metal salt.

US Patent:

20080221336, Sep 11, 2008

Filed:

Jul 12, 2006

Appl. No.:

11/995261

Inventors:

Christine E. Garrett - Bridgewater NJ, US
Guang-Pei Chen - Livingston NJ, US
George Tien-San Lee - Towaco NJ, US
Xinglong Jiang - Hillsborough NJ, US
Michael J. Girgis - Montville NJ, US
James Anthony Vivelo - Basking Ridge NJ, US
Dimitris Papoutsakis - Acton MA, US
Piotr Karpinski - Lincoln Park NJ, US
Prasad Koteswara Kapa - Parsippany NJ, US
Ada Skorodinsky - Livingston NJ, US

International Classification:

C07D 263/32

US Classification:

548235

Abstract:

This invention provides a method for preparing compounds having the structure [Formula (I)] wherein L is [Formula (A)] or [Formula (B)] in which Ris hydrogen or optionally substituted alkyl, n is zero or 1 and m is 1; wherein R is H, halogen, optionally substituted Calkyl or Calkoxy; wherein Z is a bond, O or S; wherein p is an integer from 1 to 5; wherein Q is a bond provided that Z is not a bond when p is 1; or Q is O, S or —C(O)NR— in which Ris hydrogen, optionally substituted alkyl or cycloalkyl; or Q is —NR—, —NRC(O)NH— or —NRC(O)O— in which Ris hydrogen, alkyl or aralkyl provided that p is not 1; wherein W is cycloalkyl, aryl or heterocyclyl; or W and Rform a 9- to 10-membered bicyclic ring, which may be optionally substituted or may contain oxygen, nitrogen or sulfur.

US Patent:

20090156585, Jun 18, 2009

Filed:

Nov 8, 2006

Appl. No.:

11/722360

Inventors:

Lili Feng - Pine Brook NJ, US
Sven Erik Godtfredsen - Chatham NJ, US
Bin Hu - Green Brook NJ, US
Yugang Liu - Bridgewater NJ, US
Piotr Karpinski - Lincoln Park NJ, US
Paul Allen Sutton - Parsippany NJ, US
Mahavir Prashad - Montville NJ, US
Michael J. Girgis - Montville NJ, US
Thomas J. Blacklock - Clark NJ, US

International Classification:

A61K 31/41
C07D 257/04
C07D 403/10
A61K 31/4178
A61P 9/10
A61P 25/00
A61K 31/549
A61K 31/4422
A61P 9/00
A61K 31/216
C07D 409/06
C07C 229/34

US Classification:

5142235, 548253, 5483054, 5483151, 560 39, 514381, 514394, 514397, 514382, 514533, 514356

Abstract:

A specific combination, linked pro-drug or a compound of an angiotensin receptor antagonist and a NEPi are used in the treatment of hypertension.

US Patent:

20090299065, Dec 3, 2009

Filed:

Jul 2, 2009

Appl. No.:

12/497001

Inventors:

Guang-Pei Chen - Livingston NJ, US
Prasad Koteswara Kapa - Parsippany NJ, US
Eric M. Loeser - Lake Hiawatha NJ, US
Ulrich Beutler - Oberwil, CH
Werner Zaugg - Riehen, CH
Michael John Girgis - Montville NJ, US

International Classification:

C07D 239/42
C07D 215/14
C07D 213/55

US Classification:

544297, 546173, 546342

Abstract:

A method for preparing an alkali metal salt comprising: (a) condensing a disilyloxydiene with an aldehyde in the presence of a titanium (IV) catalyst in an inert solvent to form a 5(S)-hydroxy-3-ketoester; (b) reducing the 5(S)-hydroxy-3-ketoester to a 3(R),5(S)-dihydroxyester in the presence of a di(lower alkyl)methoxyborane; and (c) hydrolyzing the 3(R),5(S)-dihydroxyester in the presence of an aqueous base to form an alkali metal salt.

US Patent:

20130184311, Jul 18, 2013

Filed:

Oct 5, 2011

Appl. No.:

13/876063

Inventors:

Paul Allen Sutton - Parsippany NJ, US
Michael J. Girgis - Montville NJ, US
Jessica Liang - Annandale NJ, US
Mahavir Prashad - Montville NJ, US
Edwin Bernard Villhauer - Morristown NJ, US

Assignee:

NOVARTIS AG - Basel

International Classification:

C07D 213/72
A61K 45/06
A61K 31/444

US Classification:

514332, 546264

Abstract:

The present invention relates to novel crystalline forms of (4-{4-[5-(6-Trifluoromethyl-pyridin-3-ylamino)-pyridin-2-yl]-phenyl}-cyclohexyl)-acetic acid, sodium and their use in the treatment or prevention of a condition or a disorder associated with DGAT1 activity in animals, particularly humans. It also relates to processes for making such novel crystalline forms.

US Patent:

52849856, Feb 8, 1994

Filed:

Oct 5, 1992

Appl. No.:

7/955774

Inventors:

Michael J. Girgis - Lawrenceville NJ
Ying-Yen P. Tsao - Lahaska PA

Assignee:

Mobil Oil Corp. - Fairfax VA

International Classification:

C07C 527

US Classification:

585310

Abstract:

The present invention provides a two-stage process for production of high-octane naphtha range isoparaffins from a feed rich in normal and/or slightly branched paraffins. In the first stage, the normal and/or slightly branched paraffins are selectively converted to multi-branched paraffins and then cracked in a second stage to yield naphtha range isoparaffins which can be blended into a high-octane gasoline pool.