Michael E Greco

US Patent:

7459444, Dec 2, 2008

Filed:

Jan 18, 2005

Appl. No.:

11/037938

Inventors:

Michael J. Hawkins - Ambler PA, US
Michael N. Greco - Lansdale PA, US
Eugene Powell - Pipersville PA, US
Lawrence de Garavilla - Downingtown PA, US
Bruce E. Maryanoff - Forest Grove PA, US

Assignee:

Janssen Pharmaceutica N.V.

International Classification:

A61K 31/66
C07F 9/28
C07F 9/38
C07F 9/40

US Classification:

514 75, 514 95, 514 79, 514 80, 514 81, 514 89, 514 96, 548414, 546 23, 558169

Abstract:

The present invention is directed to a compound of formula (I),.

US Patent:

8546358, Oct 1, 2013

Filed:

Sep 26, 2011

Appl. No.:

13/245208

Inventors:

Michael J. Hawkins - Ambler PA, US
Michael N. Greco - Lansdale PA, US
Eugene Powell - Pipersville PA, US
Lawrence de Garavilla - Downingtown PA, US
Bruce E. Maryanoff - Forest Grove PA, US

Assignee:

Janssen Pharmaceutica NV

International Classification:

A61K 31/67

US Classification:

514 96, 514826

Abstract:

The present invention is directed to a method for treating or ameliorating asthma in a subject in need thereof comprising administering to the subject a therapeutically effective amount of compound 17:.

US Patent:

20020138413, Sep 26, 2002

Filed:

Mar 26, 2001

Appl. No.:

09/816905

Inventors:

David Creamer - Horsham PA, US
Michael Greco - Davidson NC, US
Edward Finkenstaedt - Wynnewood PA, US
John Beam - Norcross GA, US

International Classification:

G06F017/60

US Classification:

705/038000

Abstract:

A method for processing a loan including the steps of partnering with a third-party service provider, providing a loan production team, providing a loan closing team, gathering loan information on-line, the loan information provided to the third-party service provider, the loan production team, and the loan closing team, concurrently executing tasks by the third-party service providers, the loan production team, and the loan closing team to close the loan.

US Patent:

20090036409, Feb 5, 2009

Filed:

Aug 20, 2008

Appl. No.:

12/229077

Inventors:

Michael J. Hawkins - Ambler PA, US
Michael N. Greco - Lansdale PA, US
Eugene Powell - Pipersville PA, US
Lawrence De Garavilla - Downingtown PA, US
Bruce E. Maryanoff - Forest Grove PA, US

International Classification:

A61K 31/662
C07F 1/00
C07F 9/572
C07F 9/576
C07F 9/58
A61K 31/665
A61K 31/675
C07F 9/60
C07F 9/6518
C07F 9/6541
C07F 9/40

US Classification:

514 82, 549 6, 514 96, 514 89, 546 22, 548414, 514 91, 546 23, 548113, 514 80, 564 15, 514119, 514100, 549220

Abstract:

The present invention is directed to a compound of formula (I),methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.

US Patent:

20100048513, Feb 25, 2010

Filed:

Aug 20, 2008

Appl. No.:

12/229089

Inventors:

Michael J. Hawkins - Ambler PA, US
Michael N. Greco - Lansdale PA, US
Eugene Powell - Pipersville PA, US
Lawrence de Garavilla - Downingtown PA, US
Bruce E. Maryanoff - Forest Grove PA, US

International Classification:

A61K 31/381
A61K 31/445
A61K 31/4535
A61K 31/662
A61P 11/00

US Classification:

514110, 514443, 514354, 514337, 514119

Abstract:

The present invention is directed to a compound of formula (I),methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.

US Patent:

20120302641, Nov 29, 2012

Filed:

May 23, 2012

Appl. No.:

13/478568

Inventors:

Devraj Chakravarty - Hillsborough NJ, US
Michael Greco - Lansdale PA, US
Brian Shook - Gilbertsville PA, US
Guozhang Xu - Bensalem PA, US
Rui Zhang - Belle Mead NJ, US

International Classification:

A61K 31/197
A61P 13/12
A61P 3/04
C07C 237/36
A61P 3/10

US Classification:

514563, 562449, 562448

Abstract:

The present invention is directed to biphenyl derivatives, pharmaceutical compositions containing them and their use in the treatment and/or prevention of disorders and conditions ameliorated by antagonizing one or more glucagon receptors, including for example metabolic diseases such as Type II diabetes mellitus and obesity.

US Patent:

58424679, Dec 1, 1998

Filed:

Jun 19, 1996

Appl. No.:

8/665942

Inventors:

Michael Greco - Garnerville NY

International Classification:

A61M 1100
A61M 1600
A62B 902

US Classification:

12820023

Abstract:

The use of a large ambulatory manual breathing unit in combination with a metered dose medication inhaler for delivering medication to a patient, who is either breathing spontaneously or non-spontaneously. The large bag or reservoir of the breathing unit is used to insure minimization of size and homogeneous disbursement of the particles of medication. For non-spontaneous patient breathing, the reservoir's contents are disbursed into the patient by manually or mechanically squeezing the bag, after which the bag returns to its original shape and volume. At one or the other end of the bag, a typical metered dose inhalator is mounted in a manner to disburse the medication into the bag, and directly in line therewith, through an adaptor. The metered dose inhaler collar, into which the inhaler fits, when the inhaler is not in use, is capped.

US Patent:

20190031618, Jan 31, 2019

Filed:

Oct 3, 2018

Appl. No.:

16/150484

Inventors:

- Beerse, BE
Rui Zhang - Belle Mead NJ, US
Yue-Mei Zhang - Wellesley MA, US
Bin Zhu - Newtown PA, US
Michael H. Parker - Chalfont PA, US
Donald W. Ludovici - Quakertown PA, US
Daniel J. Parks - Downington PA, US
Bart L. DeCorte - Southampton PA, US
Michael N. Greco - Lansdale PA, US

Assignee:

Janssen Pharmaceutica NV - Beerse

International Classification:

C07D 235/18
C07D 401/14
C07D 405/04
C07D 409/14
C07D 401/06
C07D 401/04
C07C 53/18
C07D 417/14
C07D 409/10
C07D 403/04
C07D 405/06
C07D 471/08
C07D 417/06
C07D 405/14

Abstract:

The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions mediated by the CB-1 receptor, more particularly, use in the treatment of disorders and conditions responsive to inverse agonism of the CB-1 receptor. More particularly, the compounds of the present invention are useful in the treatment of metabolic disorders.