Michael E Handley

US Patent:

7101868, Sep 5, 2006

Filed:

Apr 12, 2004

Appl. No.:

10/823809

Inventors:

Daniel Elbaum - Newton MA, US
Shon Booker - Thousand Oaks CA, US
Julie Germain - Medford MA, US
Gregory J. Habgood - Merrimac MA, US
Michael Handley - Greenbrae CA, US
Aiwen Li - Westlake Village CA, US
Nobuko Nishimura - West Hills CA, US
Vinod F. Patel - Acton MA, US
Chester Chenguang Yuan - Newbury Park CA, US
Joseph L. Kim - Wayland MA, US
Guolin Cai - Thousand Oaks CA, US
Guoqing Chen - Thousand Oaks CA, US
Michael Croghan - Thousand Oaks CA, US
Lucian V. Di Pietro - Wayland MA, US
Celia Dominguez - Thousand Oaks CA, US
Qi Huang - Moorpark CA, US
Andrew Tasker - Simi Valley CA, US
Ning Xi - Thousand Oaks CA, US
Shimin Xu - Ventura CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/33
A61K 31/44
C07D 211/62
C07D 213/72

US Classification:

514183, 514188, 514277, 514352, 514354, 514356, 546304, 546315, 546345

Abstract:

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

US Patent:

20030134836, Jul 17, 2003

Filed:

Jul 17, 2002

Appl. No.:

10/197960

Inventors:

Daniel Elbaum - Newton MA, US
Benny Askew - Newbury Park CA, US
Shon Booker - Newbury Park CA, US
Julie Germain - Somerville MA, US
Gregory Habgood - Merrimac MA, US
Michael Handley - Ventura CA, US
Aiwen Li - Westlake Village CA, US
Nobuko Nishimura - West Hills CA, US
Vinod Patel - Acton MA, US
Chester Yuan - Newbury Park CA, US
Joseph Kim - Wayland MA, US

Assignee:

Amgen Inc.

International Classification:

C07D417/02
C07D413/02
C 07D 4 3/02
C 07D 4 1/02
A61K031/55
A61K031/541
A61K031/5377
A61K031/496
A61K031/4439
A61K031/4545

US Classification:

514/210200, 514/217040, 514/227800, 514/235500, 514/253130, 514/318000, 514/336000, 540/597000, 544/060000, 546/268100, 546/194000, 544/360000, 544/131000

Abstract:

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

US Patent:

20050153960, Jul 14, 2005

Filed:

Nov 22, 2004

Appl. No.:

10/996035

Inventors:

Daniel Elbaum - Newton MA, US
Benny Askew - Newbury Park CA, US
Shon Booker - Thousand Oaks CA, US
Julie Germain - Medford MA, US
Gregory Habgood - Merrimac MA, US
Michael Handley - Greenbrae CA, US
Aiwen Li - Westlake Village CA, US
Nobuko Nishimura - West Hills CA, US
Vinod Patel - Acton MA, US
Chester Yuan - Newbury Park CA, US
Joseph Kim - Wayland MA, US
Guolin Cai - Thousand Oaks CA, US
Guoqing Chen - Thousand Oaks CA, US
Michael Croghan - Thousand Oaks CA, US
Lucian Di Pietro - Gloucester MA, US
Celia Dominguez - Thousand Oaks CA, US
Qi Huang - Moorpark CA, US
Leon Smith - Somerset NJ, US
Andrew Tasker - Simi Valley CA, US
Ning Xi - Thousand Oaks CA, US
Shimin Xu - Ventura CA, US

International Classification:

A61K031/538
A61K031/4709
A61K031/4439
A61K031/4545
C07D413/02
C07D041/02

US Classification:

514230500, 514310000, 514314000, 514337000, 514318000, 544105000, 546146000, 546167000, 546194000

Abstract:

Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.