Michael W Hanson

US Patent:

8252899, Aug 28, 2012

Filed:

Oct 22, 2008

Appl. No.:

12/739134

Inventors:

Raymond C. Stevens - La Jolla CA, US
Michael A. Hanson - San Marcos CA, US
Vadim Cherezov - San Diego CA, US
Peter Kuhn - Solana Beach CA, US

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

C07K 1/00
C07K 14/00
C12N 9/00

US Classification:

530350, 530419, 435183

Abstract:

The invention describes compositions and method useful for the crystallization of membrane proteins.

US Patent:

8536306, Sep 17, 2013

Filed:

Oct 1, 2009

Appl. No.:

13/121923

Inventors:

Raymond C. Stevens - La Jolla CA, US
Michael A. Hanson - San Marcos CA, US
Vadim Cherezov - San Diego CA, US
Mark Griffith - San Diego CA, US
Veli-Pekka Jaakola - San Diego CA, US

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

C07K 14/705

US Classification:

530350

Abstract:

The invention provides the structure of human Aadenosine receptor protein bound to an antagonist. Methods of using one or more binding sites and other features of this G-protein coupled receptor to develop new therapeutics are also disclosed.

US Patent:

20110130543, Jun 2, 2011

Filed:

Oct 22, 2008

Appl. No.:

12/739133

Inventors:

Raymond C. Stevens - La Jolla CA, US
Michael A. Hanson - San Marcos CA, US
Vadim Cherezov - San Diego CA, US

International Classification:

C07K 14/705
G06G 7/58

US Classification:

530350, 703 12

Abstract:

The invention provides the structure of a human β2-adrenergic receptor, a cholesterol consensus motif, and methods of identifying modulators of G-protein coupled receptors (GPCRs). Methods of using the modulators of the receptor, GPCRs, and the cholesterol consensus motif are also provided.

US Patent:

20120100593, Apr 26, 2012

Filed:

Sep 2, 2011

Appl. No.:

13/199611

Inventors:

Raymond C. Stevens - La Jolla CA, US
Michael A. Hanson - San Marcos CA, US
Vadim Cherezov - San Diego CA, US
Peter Kuhn - Solana Beach CA, US

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

C12N 9/96

US Classification:

435188

Abstract:

A polypeptide in crystalline form comprises a G-protein coupled receptor (GPCR) with an IC3 loop substituted by an amino acid residue sequence of lysozyme.

US Patent:

20120288913, Nov 15, 2012

Filed:

May 11, 2012

Appl. No.:

13/470104

Inventors:

Michael A. HANSON - San Marcos CA, US
Christopher B. Roth - San Diego CA, US
Raymond C. Stevens - La Jolla CA, US
Joshua M. Kunken - San Diego CA, US
Mark T. Griffith - San Diego CA, US
Aaron A. Thompson - San Diego CA, US
Wei Liu - San Diego CA, US
Fei Xu - Palm Beach Gardens FL, US
Vsevolod Katritch - San Diego CA, US

Assignee:

The Scripps Research Institute - La Jolla CA
RECEPTOS, INC. - San Diego CA

International Classification:

C12N 9/96
G06F 17/30
C07K 19/00

US Classification:

435188, 530350, 707769

Abstract:

GPCR-fusion partner proteins comprising G protein coupled receptors (GPCRs) of GPCRs and fusion partners such as rubredoxin, cytochrome b562 RIL (Bril, bRIL, BRIL), T4 lysozyme C-terminal fragment (Cterm-T4L), flavodoxin, or xylanase either substituted for some or all of the third intracellular loop of the GPCR between the fifth and sixth helix of the GPCR are described or attached to an terminus or C terminus of the GPCR. GPCR-fusion partner proteins in crystalline form, optionally of a quality suitable for x-ray crystallographic structure determination of the GPCR, are described. Methods of using fusion partners in GPCR-fusion partner proteins to support crystallization of GPCR-fusion partner proteins for x-ray crystallographic structure determination of the GPCR, are described. Methods of identifying other suitable fusion partners through screening of protein data banks are also described.

US Patent:

20130210117, Aug 15, 2013

Filed:

Mar 28, 2013

Appl. No.:

13/852401

Inventors:

The Scripps Research Institute - , US
Michael A. Hanson - San Marcos CA, US
Vadim Cherezov - San Diego CA, US
Peter Kuhn - Solana Beach CA, US

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

C07K 14/72
C12N 9/96
C12N 9/24

US Classification:

435188, 435206

Abstract:

A polypeptide in crystalline form comprises a G-protein coupled receptor (GPCR) with an IC3 loop substituted by an amino acid residue sequence of lysozyme.

US Patent:

54303621, Jul 4, 1995

Filed:

May 12, 1993

Appl. No.:

8/063166

Inventors:

Kenneth R. Carr - Redmond WA
Gregory I. Rozman - Rockford IL
Albert L. Markunas - Roscoe IL
Michael J. Hanson - Loves Park IL
Leland E. Weber - Rockford IL
James A. Shippling - Erie PA
Malcolm J. McArthur - Escondido CA
Vijay K. Maddali - Rockford IL
Paul E. Nuechterlein - Rockford IL
Alexander Cook - Belvidere IL
Vietson Nguyen - Rockford IL
Mario R. Rinaldi - Rockford IL

Assignee:

Sundstrand Corporation - Rockford IL

International Classification:

H02P 146

US Classification:

318779

Abstract:

A control for operating an electromagnetic machine in a starting mode of operation wherein the main armature winding of the machine receives electrical power from a controllable power source during the starting mode of operation, comprises a circuit for detecting a magnitude of a parameter of power applied to the main armature winding relative to a stationary frame of reference, a position sensor for detecting rotor position of the electromagnetic machine, a converter responsive to angular position indication for converting the detected parameter magnitude into field and torque producing components relative to a rotating frame of reference, and a circuit responsive to the field and torque producing components for controlling the power source during operation in the starting mode. This control includes an igniter for igniting a prime mover. Further, the control is operable during a first phase prior to ignition of the prime mover for causing the electromagnetic machine to provide motive power to the prime mover so as to accelerate the prime mover at a first predetermined rate, is operable during a second phase subsequent to the first phase so as to accelerate the prime mover at a second predetermined rate, is operable during this second phase for providing fuel to the prime mover to facilitate ignition thereof, and is operable during a third phase subsequent to the ignition of the prime mover so as to accelerate the prime mover at a third predetermined rate to a self-sustaining speed.