Michael J Healy

US Patent:

6358443, Mar 19, 2002

Filed:

Jun 6, 2000

Appl. No.:

09/587821

Inventors:

Paul F. Herbert - Wayland MA
Michael S. Healy - East Bridgewater MA

Assignee:

Alkermes Controlled Therapeutics, Inc. - Cambridge MA

International Classification:

A61K 914

US Classification:

264 5, 264 13

Abstract:

The present invention relates to a method for forming microparticles of a material from microdroplets of a solution, wherein the solution comprises the material dissolved in a solvent. The method includes the steps of directing the microdroplets into a freezing zone, wherein the freezing zone is surrounded by a liquified gas, and wherein the microdroplets freeze. The frozen microdroplets are then mixed with a liquid non-solvent, whereby the solvent is extracted into the non-solvent, thereby forming the microparticles.

US Patent:

6569458, May 27, 2003

Filed:

Jan 21, 1993

Appl. No.:

08/006682

Inventors:

Wayne R. Gombotz - Lexington MA
Michael S. Healy - Bridgewater MA
Larry R. Brown - Newton MA
Henry E. Auer - Watertown MA

Assignee:

Alkermes Controlled Therapeutics, Inc. - Cambridge MA

International Classification:

A61K 916

US Classification:

424489, 424499, 424502, 424600

Abstract:

Small diameter particles of biologically active molecules are produced by atomizing solutions of the molecules through a nozzle into very cold liquified gases, which immediately freeze the atomized droplets. The resulting frozen particles having diameters of approximately 10 to 90 micrometers are lyophilized to produce porous particles, suspended in a non-solvent for the molecules, and exposed to ultrasonic energy or homogenization to produce particles having diameters of 0. 1 to 10 micrometers with greater than 70 to 95% of the initial biological activity of the molecules in solution.

US Patent:

6726860, Apr 27, 2004

Filed:

Dec 6, 2001

Appl. No.:

10/006991

Inventors:

Paul F. Herbert - Wayland MA
Michael S. Healy - East Bridgewater MA

Assignee:

Alkermes Controlled Therapeutics, Inc. - Cambridge MA

International Classification:

B29B 2902

US Classification:

264 5, 264 13

Abstract:

The present invention relates to a method for forming microparticles of a material from microdroplets of a solution, wherein the solution comprises the material dissolved in a solvent. The method includes the steps of directing the microdroplets into a freezing zone, wherein the freezing zone is surrounded by a liquified gas, and wherein the microdroplets freeze. The frozen microdroplets are then mixed with a liquid non-solvent, whereby the solvent is extracted into the non-solvent, thereby forming the microparticles.

US Patent:

7037450, May 2, 2006

Filed:

Feb 23, 2004

Appl. No.:

10/784474

Inventors:

Paul F. Herbert - Wayland MA, US
Michael S. Healy - East Bridgewater MA, US

Assignee:

Alkermes Controlled Therapeutics, Inc. - Cambridge MA

International Classification:

B29B 9/02
A61K 9/14
A61K 9/16
B01J 2/04

US Classification:

264 5, 264 13

Abstract:

The present invention relates to a method for forming microparticles of a material from microdroplets of a solution, wherein the solution comprises the material dissolved in a solvent. The method includes the steps of directing the microdroplets into a freezing zone, wherein the freezing zone is surrounded by a liquified gas, and wherein the microdroplets freeze. The frozen microdroplets are then mixed with a liquid non-solvent, whereby the solvent is extracted into the non-solvent, thereby forming the microparticles.

US Patent:

7720077, May 18, 2010

Filed:

May 22, 2008

Appl. No.:

12/125876

Inventors:

Michael Healy - Boxborough MA, US
Yuen-Wen Lee - San Jose CA, US
Yihuan Sun - San Jose CA, US

Assignee:

Cisco Technology, Inc. - San Jose CA

International Classification:

H04L 12/28

US Classification:

37039562, 370401

Abstract:

In one embodiment, a gateway for a constant delay network identifies a baseband clock that is synchronized by exchanging synchronization messages over a packet switched network. The gateway then generates a strobe by manipulating the identified baseband clock using a custom multiplier that is selected according to transmission variables. The gateway then signals a front end component to process fixed length packets for transfer to a back end component according to the generated strobe, which can reduce or eliminate buffering by the back end component and can improve cable modem operation.

US Patent:

8081659, Dec 20, 2011

Filed:

Jul 2, 2008

Appl. No.:

12/167168

Inventors:

Pawel Sowinski - Northborough MA, US
Michael J. Healy - Berlin MA, US
John T. Chapman - Laguna Niguel CA, US
Daniel W. Crocker - San Jose CA, US

Assignee:

Cisco Technology, Inc. - San Jose CA

International Classification:

H04J 3/16

US Classification:

370468, 370389, 725111

Abstract:

An M-CMTS compatible UEQAM device implements circuitry to identify and analyze MAP message in the data stream sent from the M-CMTS Core with respect to timing information embedded in those messages. The improved UEQAM will then create a specific message as an extension to DEPI to communicate that information to the M-CMTS Core. The M-CMTS Core will employ that analysis to automatically adjust MAP message advance time to reduce delay and thus improve system performance. This invention will provide a closed-loop between the M-CMTS Core and the UEQAM where valuable transmission information will periodically be fed back from UEQAM-to-M-CMTS Core in real-time.

US Patent:

8121116, Feb 21, 2012

Filed:

May 30, 2008

Appl. No.:

12/130305

Inventors:

Michael Healy - Berlin MA, US
Yuen-Wen Lee - Milpitas CA, US
Yi Tong Tse - San Jose CA, US

Assignee:

Cisco Technology, Inc. - San Jose CA

International Classification:

H04L 12/28

US Classification:

370389, 370349, 370235, 370253

Abstract:

In one embodiment, a gateway between a variable delay network and a constant delay network receives over the variable delay network a plurality of data streams to be multiplexed over a modulated channel extending through the constant delay network. A first processing component of the gateway generates command-packet-descriptors corresponding to content packets included in the received data streams. A second processing component of the gateway uses transmit time indications included in the command-packet-descriptors to schedule transmission of modulated packets representing the received data streams over the modulated channel.

US Patent:

20050242946, Nov 3, 2005

Filed:

Oct 20, 2003

Appl. No.:

10/531486

Inventors:

James Hubbard - Derry NH, US
Michael Healy - Boston MA, US
Marianne Mastrangelo - Lynnfield MA, US

International Classification:

G08B001/08

US Classification:

340539120, 340573100, 340531000, 600300000

Abstract:

A patient activity monitoring system that allows caregivers of multiple patients to work more efficiently and with reduced cost, while increasing the quality and level of patient care. The system includes a plurality of remote monitoring subsystems, a plurality of user notification units, and a central monitoring unit with a Graphical User Interface (GUI) communicably coupled between the remote monitoring and user notification units. Each remote monitoring subsystem includes a remote monitoring unit, and a sensor device associated with a respective patient that detects one or more activity and/or physiological parameters of the patient. A simplified user interface including the GUI and the user notification units provides indications of the type and level of assistance required by one or more patients to caregivers at centralized and remote locations.