Michael P Healy

US Patent:

6358443, Mar 19, 2002

Filed:

Jun 6, 2000

Appl. No.:

09/587821

Inventors:

Paul F. Herbert - Wayland MA
Michael S. Healy - East Bridgewater MA

Assignee:

Alkermes Controlled Therapeutics, Inc. - Cambridge MA

International Classification:

A61K 914

US Classification:

264 5, 264 13

Abstract:

The present invention relates to a method for forming microparticles of a material from microdroplets of a solution, wherein the solution comprises the material dissolved in a solvent. The method includes the steps of directing the microdroplets into a freezing zone, wherein the freezing zone is surrounded by a liquified gas, and wherein the microdroplets freeze. The frozen microdroplets are then mixed with a liquid non-solvent, whereby the solvent is extracted into the non-solvent, thereby forming the microparticles.

US Patent:

6569458, May 27, 2003

Filed:

Jan 21, 1993

Appl. No.:

08/006682

Inventors:

Wayne R. Gombotz - Lexington MA
Michael S. Healy - Bridgewater MA
Larry R. Brown - Newton MA
Henry E. Auer - Watertown MA

Assignee:

Alkermes Controlled Therapeutics, Inc. - Cambridge MA

International Classification:

A61K 916

US Classification:

424489, 424499, 424502, 424600

Abstract:

Small diameter particles of biologically active molecules are produced by atomizing solutions of the molecules through a nozzle into very cold liquified gases, which immediately freeze the atomized droplets. The resulting frozen particles having diameters of approximately 10 to 90 micrometers are lyophilized to produce porous particles, suspended in a non-solvent for the molecules, and exposed to ultrasonic energy or homogenization to produce particles having diameters of 0. 1 to 10 micrometers with greater than 70 to 95% of the initial biological activity of the molecules in solution.

US Patent:

6726860, Apr 27, 2004

Filed:

Dec 6, 2001

Appl. No.:

10/006991

Inventors:

Paul F. Herbert - Wayland MA
Michael S. Healy - East Bridgewater MA

Assignee:

Alkermes Controlled Therapeutics, Inc. - Cambridge MA

International Classification:

B29B 2902

US Classification:

264 5, 264 13

Abstract:

The present invention relates to a method for forming microparticles of a material from microdroplets of a solution, wherein the solution comprises the material dissolved in a solvent. The method includes the steps of directing the microdroplets into a freezing zone, wherein the freezing zone is surrounded by a liquified gas, and wherein the microdroplets freeze. The frozen microdroplets are then mixed with a liquid non-solvent, whereby the solvent is extracted into the non-solvent, thereby forming the microparticles.

US Patent:

7037450, May 2, 2006

Filed:

Feb 23, 2004

Appl. No.:

10/784474

Inventors:

Paul F. Herbert - Wayland MA, US
Michael S. Healy - East Bridgewater MA, US

Assignee:

Alkermes Controlled Therapeutics, Inc. - Cambridge MA

International Classification:

B29B 9/02
A61K 9/14
A61K 9/16
B01J 2/04

US Classification:

264 5, 264 13

Abstract:

The present invention relates to a method for forming microparticles of a material from microdroplets of a solution, wherein the solution comprises the material dissolved in a solvent. The method includes the steps of directing the microdroplets into a freezing zone, wherein the freezing zone is surrounded by a liquified gas, and wherein the microdroplets freeze. The frozen microdroplets are then mixed with a liquid non-solvent, whereby the solvent is extracted into the non-solvent, thereby forming the microparticles.

US Patent:

7720077, May 18, 2010

Filed:

May 22, 2008

Appl. No.:

12/125876

Inventors:

Michael Healy - Boxborough MA, US
Yuen-Wen Lee - San Jose CA, US
Yihuan Sun - San Jose CA, US

Assignee:

Cisco Technology, Inc. - San Jose CA

International Classification:

H04L 12/28

US Classification:

37039562, 370401

Abstract:

In one embodiment, a gateway for a constant delay network identifies a baseband clock that is synchronized by exchanging synchronization messages over a packet switched network. The gateway then generates a strobe by manipulating the identified baseband clock using a custom multiplier that is selected according to transmission variables. The gateway then signals a front end component to process fixed length packets for transfer to a back end component according to the generated strobe, which can reduce or eliminate buffering by the back end component and can improve cable modem operation.

US Patent:

8576842, Nov 5, 2013

Filed:

Jul 28, 2011

Appl. No.:

13/192844

Inventors:

John T. Chapman - Laguna Niguel CA, US
Denis Downey - Pleasanton CA, US
Michael J. Healy - Concord MA, US
Yi Tong Tse - San Jose CA, US

Assignee:

Cisco Technology, Inc. - San Jose CA

International Classification:

H04L 12/28
H04J 1/16

US Classification:

370389, 370252, 370487

Abstract:

A system, and related methodology, are provided that are configured to receive, at a first network element such as a Universal Edge Quadrature Amplitude Modulator (UEQAM), multiple channels of data delivered as respective streams of packets, form a packet switched communication frame including a sub-layer header, encapsulate packets from the respective multiple channels into a payload field of the packet switched communication frame, identify the packets encapsulated in the payload field with respective tags in the sub-layer header, and transmit the packet switched communication frame to a second network element such as a Downstream Physical (DS-PHY) entity where the individual packets are recovered and mapped to selected respective stream processing resources based on respective tags.

US Patent:

20140079060, Mar 20, 2014

Filed:

Sep 14, 2012

Appl. No.:

13/616407

Inventors:

Michael J. Healy - Concord MA, US
John T. Chapman - Laguna Niguel CA, US
Denis Downey - Pleasanton CA, US
Yi Tong Tse - San Jose CA, US

Assignee:

Cisco Technology, Inc. - San Jose CA

International Classification:

H04L 12/56

US Classification:

370392

Abstract:

A system and related methodology are provided that are configured to receive, at a first network element, multiple channels of video delivered as respective streams of packets, form a packet switched communication frame including a sub-layer header, encapsulate packets from the multiple channels of video into a payload field of the communication frame to obtain encapsulated packets, identify the encapsulated packets in the payload field with respective tags in the sub-layer header, designate the encapsulated packets in the payload field with respective launch values in the sub-layer header, and transmit the communication frame to a second network element. The first network element may be a universal edge quadrature amplitude modulator (UEQAM) and the second network element may be a relatively distant fiber node of a cable plant. The sub-layer header may also include Program Clock Reference (PCR) offset data that can be used for PCR re-stamping.

US Patent:

61531294, Nov 28, 2000

Filed:

May 5, 1999

Appl. No.:

9/305413

Inventors:

Paul F. Herbert - Wayland MA
Michael S. Healy - East Bridgewater MA

Assignee:

Alkermes Controlled Therapeutics, Inc. - Cambridge MA

International Classification:

B29B 902

US Classification:

264 5

Abstract:

The present invention relates to a method for forming microparticles of a material from microdroplets of a solution, wherein the solution comprises the material dissolved in a solvent. The method includes the steps of directing the microdroplets into a freezing zone, wherein the freezing zone is surrounded by a liquified gas, and wherein the microdroplets freeze. The frozen microdroplets are then mixed with a liquid non-solvent, whereby the solvent is extracted into the non-solvent, thereby forming the microparticles.