Michael E Hepperle
age ~75
from Las Vegas, NV
- Also known as:
-
- Michael Dr Hepperle
- Michael Hepperl
- Michael L
Michael Hepperle Phones & Addresses
- Las Vegas, NV
- Aberdeen, MD
- Baltimore, MD
- San Diego, CA
- Chula Vista, CA
- Saint Louis, MO
- Boston, MA
Work
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Company:UsamricdJan 2014
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Position:Medicinal chemist
Education
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Degree:Doctorates, Doctor of Philosophy
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School / High School:The University of Kansas1989 to 1995
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Specialities:Chemistry
Skills
Drug Discovery • Omnicompatible and Interconnecting Leader • Change and Transition Leader • Medicinal Chemistry • Drug Design • Biotechnology • Lifesciences • Oncology • Pharmaceutical Industry • Organic Synthesis • Organic Chemistry • Drug Development • Chemistry • R&D • Technology Transfer • Life Cycle Management • Patent Search and Evaluation • Virtual Drug Discovery • Global Cro Management • Chromatography • Cro • Hplc • High Throughput Screening • Product Lifecycle Management • Analytical Chemistry • Pharmacokinetics • Lead Change • Lc Ms • Pharmaceutical Research • Small Molecules • Inflammation • Biochemistry • Nmr • Pharmaceutics • Heterocyclic Chemistry • Cheminformatics • Adme • Synthetic Organic Chemistry • Molecular Modeling • Biomarker Discovery • Life Sciences • Research and Development
Languages
English • German
Ranks
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Certificate:Science and Technology Management Level Ii
Industries
Research
Us Patents
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Alpha Carbolines And Uses Thereof
view source -
US Patent:7812018, Oct 12, 2010
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Filed:Feb 15, 2007
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Appl. No.:11/706760
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Inventors:Michael E. Hepperle - San Diego CA, US
Julie Fields Liu - Lexington MA, US
R. Scott Rowland - Swampscott MA, US
Dilrukshi Vitharana - Somerville MA, US -
Assignee:Millennium Pharmaceuticals, Inc. - Cambridge MA
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International Classification:A61K 31/437
C07D 413/14
C07D 471/06 -
US Classification:5142328, 514292, 544126, 546 87
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Abstract:This invention provides alpha-carboline compounds of formula I:.
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Alpha Carbolines And Uses Thereof
view source -
US Patent:8101604, Jan 24, 2012
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Filed:Aug 19, 2010
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Appl. No.:12/859312
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Inventors:Michael E. Hepperle - San Diego CA, US
Julie Fields Liu - Lexington MA, US
R. Scott Rowland - Swampscott MA, US
Dilrukshi Vitharana - Somerville MA, US -
Assignee:Millennium Pharmaceuticals, Inc. - Cambridge MA
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International Classification:A61K 31/437
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US Classification:5142328
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Abstract:This invention provides alpha-carboline compounds of formula I:.
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Hepatitis C Serine Protease Inhibitors And Uses Therefor
view source -
US Patent:20090304631, Dec 10, 2009
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Filed:Jan 25, 2007
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Appl. No.:12/162268
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Inventors:David Alan Campbell - San Diego CA, US
Michael E. Hepperle - San Diego CA, US
Juan Manuel Betancort - San Diego CA, US
David T. Winn - San Diego CA, US -
International Classification:A61K 31/69
C07F 5/02
C07D 403/12
A61K 39/395
A61K 38/16
A61K 38/21
A61P 31/12 -
US Classification:424 857, 548405, 548465, 546 13, 514 64, 4241331, 514 12, 424 854
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Abstract:The invention provides compounds that inhibit a viral protease enzyme of the hepatitis C virus (HCV). The compounds are adapted for treatment of a HCV infection in a patient with the disease. The compounds include analogs of tripeptides and tetrapeptides that resemble the viral protease substrate. The invention also provides pharmaceutical compositions and combinations, methods of preparation of the compounds, and methods of treatment of patients afflicted with HCV using the compounds.
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Hepatitis C Serine Protease Inhibitors And Uses Therefor
view source -
US Patent:20090325889, Dec 31, 2009
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Filed:Jul 28, 2006
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Appl. No.:11/996280
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Inventors:David Alan Campbell - San Diego CA, US
David T. Winn - San Diego CA, US
Juan Manuel Betancort - San Diego CA, US
Michael E. Hepperle - San Diego CA, US -
International Classification:A61K 38/06
C12N 9/99
A61K 38/05
C07K 5/083
C07F 5/02
A61P 31/12 -
US Classification:514 18, 435184, 514 19, 530331, 546 13, 549 4, 549213, 564 8
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Abstract:The present invention provides novel compounds which mimic peptides with a C-terminal penultimate proline, such compounds being useful as protease inhibitors, particularly as inhibitors of serine proteases, and more particularly as inhibitors of the NS3 serine protease from hepatitis C. The compounds find utility as antiviral agents directed at hepatitis C. The invention further provides methods of employing such inhibitors, alone or in combination with other therapeutic agents, to treat hepatitis C infection in a subject in need of such treatment.
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Beta-Carbolines Useful For Treating Inflammatory Disease
view source -
US Patent:20100093713, Apr 15, 2010
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Filed:Dec 17, 2009
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Appl. No.:12/640335
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Inventors:Michael E. Hepperle - San Diego CA, US
Julie Fields Liu - Lexington MA, US
Francois Soucy - Stoneham MA, US
Yingchun Ye - Belmont MA, US
Robert S. Murray - Framingham MA, US
Raman Prakash - Acton MA, US
Jeremy D. Little - Wakefield MA, US
Alfredo Castro - Winchester MA, US
Hormoz Mazdiyasni - Marlborough MA, US
Paul E. Fleming - Wellesley MA, US
Dominic Reynolds - Stoneham MA, US -
Assignee:Millennium Pharmaceuticals, Inc. - Cambridge MA
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International Classification:A61K 31/541
C07D 471/04
A61P 35/04
A61P 37/00
A61K 31/5377
A61P 29/00
A61K 31/501
A61K 31/437
C07D 295/10 -
US Classification:5142282, 546 87, 544333, 544126, 544 582, 544 82, 5142325, 5142328, 514256, 514292, 544175
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Abstract:This invention provides beta-carboline compounds of formula
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Macrocyclic Hepatitis C Serine Protease Inhibitors And Uses Therefor
view source -
US Patent:20100120716, May 13, 2010
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Filed:Dec 5, 2007
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Appl. No.:12/515941
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Inventors:David A. Campbell - San Diego CA, US
Michael E. Hepperle - San Diego CA, US
David T. Winn - San Diego CA, US
Juan M. Betancort - San Diego CA, US -
Assignee:Phenomix Corporation - San Diego CA
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International Classification:A61K 31/69
C07D 267/00
C07D 245/04
A61P 31/12 -
US Classification:514 64, 540452
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Abstract:Macrocyclic inhibitors of Hepatitis C protease are provided, the inhibitors including a boronic acid or ester group, a macrocyclic ring of about 13 to 25 atoms including at least two amide linkages, a proline-analogous group, and a connecting segment joining moieties on either side of the proline-analogous group. Methods of making the HCV protease-inhibitory compounds, methods of using the compounds, formulations of the compounds, and pharmaceutical combinations including the compounds, are provided.
Resumes
Michael Hepperle
view sourceLocation:
5023 37Th St north, Saint Petersburg, FL 33714
Industry:
Research
Work:
Usamricd
Medicinal Chemist
Virtual Drug Discovery Solutions Feb 2013 - Dec 2013
Principal and Owner
Nycomed May 2009 - Dec 2012
Director, Head of Medicinal Chemistry and Drugability Properties
Phenomix Corporation Oct 2005 - Apr 2009
Director, Medicinal Chemistry
Takeda Oncology Feb 2002 - Sep 2005
Senior Scientist Ii and I
Medicinal Chemist
Virtual Drug Discovery Solutions Feb 2013 - Dec 2013
Principal and Owner
Nycomed May 2009 - Dec 2012
Director, Head of Medicinal Chemistry and Drugability Properties
Phenomix Corporation Oct 2005 - Apr 2009
Director, Medicinal Chemistry
Takeda Oncology Feb 2002 - Sep 2005
Senior Scientist Ii and I
Education:
The University of Kansas 1989 - 1995
Doctorates, Doctor of Philosophy, Chemistry Heidelberg University 1983 - 1988
Doctorates, Doctor of Philosophy, Chemistry Heidelberg University 1983 - 1988
Skills:
Drug Discovery
Omnicompatible and Interconnecting Leader
Change and Transition Leader
Medicinal Chemistry
Drug Design
Biotechnology
Lifesciences
Oncology
Pharmaceutical Industry
Organic Synthesis
Organic Chemistry
Drug Development
Chemistry
R&D
Technology Transfer
Life Cycle Management
Patent Search and Evaluation
Virtual Drug Discovery
Global Cro Management
Chromatography
Cro
Hplc
High Throughput Screening
Product Lifecycle Management
Analytical Chemistry
Pharmacokinetics
Lead Change
Lc Ms
Pharmaceutical Research
Small Molecules
Inflammation
Biochemistry
Nmr
Pharmaceutics
Heterocyclic Chemistry
Cheminformatics
Adme
Synthetic Organic Chemistry
Molecular Modeling
Biomarker Discovery
Life Sciences
Research and Development
Omnicompatible and Interconnecting Leader
Change and Transition Leader
Medicinal Chemistry
Drug Design
Biotechnology
Lifesciences
Oncology
Pharmaceutical Industry
Organic Synthesis
Organic Chemistry
Drug Development
Chemistry
R&D
Technology Transfer
Life Cycle Management
Patent Search and Evaluation
Virtual Drug Discovery
Global Cro Management
Chromatography
Cro
Hplc
High Throughput Screening
Product Lifecycle Management
Analytical Chemistry
Pharmacokinetics
Lead Change
Lc Ms
Pharmaceutical Research
Small Molecules
Inflammation
Biochemistry
Nmr
Pharmaceutics
Heterocyclic Chemistry
Cheminformatics
Adme
Synthetic Organic Chemistry
Molecular Modeling
Biomarker Discovery
Life Sciences
Research and Development
Languages:
English
German
German
Certifications:
Science and Technology Management Level Ii
Program Management Level I
Dawia
Program Management Level I
Dawia
Michael Hepperle
view source
Michael Hepperle
view sourceFriends:
Amogh Boloor, Eva Rodi, Charles Stiehl, Harry An, Alan Xiang
Youtube
Classmates
Jersey Shore Area Junior ...
view sourceGraduates:
Michael Noltee (1974-1978),
Mike Hepperle (1995-1999),
Patricia Woodring (1959-1963),
Lisa Harris (1985-1989),
Mari Beth Rhinehart (1997-2001)
Mike Hepperle (1995-1999),
Patricia Woodring (1959-1963),
Lisa Harris (1985-1989),
Mari Beth Rhinehart (1997-2001)
Get Report for Michael E Hepperle from Las Vegas, NV, age ~75