Michael L Howland

US Patent:

61784710, Jan 23, 2001

Filed:

Jul 21, 1998

Appl. No.:

9/119821

Inventors:

Robert C. Barrett - San Jose CA
Michael J. Howland - Vestal NY
Steven M. Pritko - Endicott NY

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 305

US Classification:

710 52

Abstract:

Downstream buffer objects are slaved with the immediate upstream buffer object using a conventional "write remaining" method. The write remaining method can be invoked from each of a plurality of modules having access to the read and write pipes, and operates to slave not the data, but wrappers that point to the data and which therefore represent references to a single copy of the data stored as an upstream data buffer object, so that the actual data need exist in only one place after the write remaining method has been invoked, rather than requiring the data to be sequentially copied from one data buffer to the next. This method further has the benefit of allowing control to be returned to the module during the data transfer function, and of allowing additional data to be written to the outbound pipe.

US Patent:

20220233536, Jul 28, 2022

Filed:

May 28, 2020

Appl. No.:

17/613651

Inventors:

- San Francisco CA, US
Michael Monteith - Raleigh NC, US
Gang Li - San Diego CA, US
Susan Arangio - Los Altos CA, US
Craig Berman - Mill Valley CA, US
Michael Howland - San Francisco CA, US
Daniel Mulreany - San Francisco CA, US
Carl Dambkowski - San Mateo CA, US

International Classification:

A61K 31/506
A61P 35/04

Abstract:

Provided herein are methods of treating advanced or metastatic cholangiocarcinoma in a patient by administering to the patient infigratinib or a pharmaceutically acceptable salt thereof, wherein the patient has progression of the cholangiocarcinoma after previous administration of another therapy.