Michael David Jensen

US Patent:

8329882, Dec 11, 2012

Filed:

Feb 18, 2010

Appl. No.:

12/708506

Inventors:

Christina D. Smolke - Stanford CA, US
Yvonne Y. Chen - Pasadena CA, US
Michael C. Jensen - Sierra Madre CA, US

Assignee:

California Institute of Technology - Pasadena CA
City of Hope - Duarte CA

International Classification:

C07H 21/02
C07H 21/04
C12N 5/00
C12N 5/02

US Classification:

536 231, 536 241, 536 245, 435375

Abstract:

The present application relates to nucleic acids that encode a RNA switch responsive to a ligand that can control the expression of a gene product that affects the cell fate determination of a mammalian cell are provided. In some embodiments, the system can be used to control the proliferation or activation of mammalian cells in response to a ligand that can be provided exogenously to the mammalian cell or can be produced by the mammalian cell. The system can be used to promote the growth or proliferation of human T cells in response to an exogenous ligand applied to the cells. In one embodiment, the system detects the ligand through a RNA aptamer that modulates expression of a gene product through activation or inactivation of a ribozyme that modulates expression of the gene product.

US Patent:

20080188000, Aug 7, 2008

Filed:

Nov 13, 2007

Appl. No.:

11/983888

Inventors:

Andreas Reik - Vallejo CA, US
Michael Jensen - Sierra Madre CA, US
Michael C. Holmes - Oakland CA, US
Philip D. Gregory - Orinda CA, US
Dale Ando - Walnut Creek CA, US

International Classification:

C12N 15/87
C07K 16/00
C07H 21/04

US Classification:

435463, 530350, 536 234

Abstract:

Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.

US Patent:

20090047712, Feb 19, 2009

Filed:

Aug 15, 2007

Appl. No.:

11/893596

Inventors:

Keith Anderson - Moss Beach CA, US
Michael Jensen - Los Gatos CA, US
Ronald W. Davis - Palo Alto CA, US

International Classification:

C07H 21/00
C07H 21/02
C07H 21/04
C07H 19/00
C12P 19/34

US Classification:

435 912, 536 2621, 536 2534, 536 2531, 536 231, 536 2433

Abstract:

The present invention provides phosphoramidite linkers that are useful for the production of synthesizing two or more oligonucleotides in tandem. The inventive linkers have the following desirable properties: (i) enhanced stability to alkali conditions versus the linkers previously published, (ii) cleave to produce 5′ and 3′ ends that are fully biologically compatible, (iii) cleave completely under conditions that are already used in cleavage/deprotection processes so they are fully compatible with conditions that are common in laboratories and do not require additives that necessitate further purification after cleavage, (iv) integrate easily onto commercially available synthesizers because they are compatible with standard coupling chemistry, and (v) are compatible with DNA, RNA, forward, reverse, and synthesis chemistries. In addition, the inventive linkers may be coupled to a solid support. Thus, the inventive linkers provide a significant advancement in the state of the art.

US Patent:

20190361973, Nov 28, 2019

Filed:

Aug 12, 2019

Appl. No.:

16/538607

Inventors:

- San Francisco CA, US
Michael Jensen - San Francisco CA, US

International Classification:

G06F 17/24
H04L 29/06
G06F 17/22
G06Q 30/02

Abstract:

Approaches, techniques, and mechanisms are disclosed for automatically inserting supplemental items into documents. According to an embodiment, a first request is received, comprising document information that identifies a particular document. A target repeated structure type, to which a group of items in the particular document conform, is identified within the particular document. Based on the target repeated structure type, a template is generated. A new content item is generated by applying descriptive metadata that describes the new content item to the template. The new content item conforms to the target repeated structure type. The new content item is inserted in the particular document at an insertion point before or after a particular content item that conforms to the target repeated structure type.

US Patent:

20190356577, Nov 21, 2019

Filed:

May 15, 2018

Appl. No.:

15/979535

Inventors:

- Atlanta GA, US
Michael JENSEN - East Palo Alto CA, US

International Classification:

H04L 12/721
H04L 12/707
H04L 12/725
H04L 12/24

Abstract:

A network diversity resolution system comprising: a diversity assessment tool, the diversity assessment tool including a path finding module and a sampling module that communicate with an input/output device; the path finding module communicates with an enterprise data warehouse; the path finding module configured to search through a network inventory stored in the enterprise data warehouse, the path finding module constructing a representation to identify at least two representative paths between a selected first end point and a second end point; wherein the at least two representative paths meets at least a capacity requirement between the first end point and the second end point; and wherein the sampling module generates at least one circuit reassignment plan based on the at least two representative paths, wherein the sampling module provides a score for each of the at least one circuit reassignment plan, wherein the score is based on at least one of a machine preference, path length, and number of changes to implement the at least one circuit reassignment plan, wherein the at least one circuit reassignment plan incorporates at least one representative path having a highest score.

US Patent:

20180000264, Jan 4, 2018

Filed:

Jun 30, 2016

Appl. No.:

15/198051

Inventors:

- Waunakee WI, US
Benjamin John Peters - Madison WI, US
Michael David Jensen - Verona WI, US

International Classification:

A47G 1/06

Abstract:

An art frame assembly comprises an outer frame and an inner artwork subassembly. The outer frame includes a central opening. The inner artwork subassembly is disposed within the central opening of the outer frame and includes a artwork sheet and a structural liner. The structural liner defines an open-faced box-like structure and includes a front surface, a back surface, and a plurality of folded side walls. The folded side walls are coupled to the artwork sheet and are folded away from the front surface of the structural liner towards the back surface of the structural liner.

US Patent:

20160283460, Sep 29, 2016

Filed:

Jun 3, 2016

Appl. No.:

15/173552

Inventors:

- San Francisco CA, US
Michael Jensen - San Francisco CA, US

International Classification:

G06F 17/24
H04L 29/06
G06F 17/22

Abstract:

Approaches, techniques, and mechanisms are disclosed for automatically inserting supplemental items into documents. According to an embodiment, a first request is received, comprising document information that identifies a particular document. A target repeated structure type, to which a group of items in the particular document conform, is identified within the particular document. Based on the target repeated structure type, a template is generated. A new content item is generated by applying descriptive metadata that describes the new content item to the template. The new content item conforms to the target repeated structure type. The new content item is inserted in the particular document at an insertion point before or after a particular content item that conforms to the target repeated structure type.

US Patent:

20150154660, Jun 4, 2015

Filed:

Dec 3, 2013

Appl. No.:

14/095163

Inventors:

- San Francisco CA, US
Michael Jensen - San Francisco CA, US

Assignee:

Sharethrough Inc. - San Francisco CA

International Classification:

G06Q 30/02

Abstract:

Approaches, techniques, and mechanisms are disclosed for automatically inserting supplemental items into documents. According to an embodiment, a first request is received, comprising document information that identifies a particular document. A target repeated structure type, to which a group of items in the particular document conform, is identified within the particular document. Based on the target repeated structure type, a template is generated. A new content item is generated by applying descriptive metadata that describes the new content item to the template. The new content item conforms to the target repeated structure type. The new content item is inserted in the particular document at an insertion point before or after a particular content item that conforms to the target repeated structure type.